|Cat. No. 124-01P||100 µg protein, lyophilized. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.|
|Immunogen||Recombinant protein corresponding to AA 68 to 251 from mouse PSD95 (UniProt Id: Q62108)|
|Recommended dilution||Optimal concentrations should be determined by the end-user.|
|Matching antibodies||124 011, 124 011BT, 124 012, 124 014, 124 008, 124 308, N3702-AF647-L, N3702-At488-L|
This control protein consists of the recombinant protein (aa 68-251 of mouse PSD 95) that has been used for immunization. It has been tested in preadsorption experiments and blocks efficiently and specifically the corresponding signal in Western blots. The amount of protein needed for efficient blocking depends on the titer and on the affinity of the antibody to the antigen.
PSD95 (postsynaptic density protein 95 kDa, also called SAP 90: synapse associated protein of 90 kDa and DLG 4) is a component of postsynaptic densities in central synapses. It contains three PDZ domains. The first and second PDZ domain localizes NMDA receptors and K+ channels to synapses, the third binds to neuroligins which are neuronal cell adhesion molecules that interact with β-neurexins and form intercellular junctions. Thus different PDZ domains of PSD 95 might be specialized for distinct functions. Read more: PSD95 single domain antibody