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PSD95 antibody PDZ domain - 124 011BT

PSD 95 is a component of postsynaptic densities in central synapses
Mouse monoclonal purified IgG
Cat. No.: 124 011BT
Amount: 100 µg
Price: $465.00
Cat. No. 124 011BT 100 µg purified IgG, lyophilized, biotin-labeled. Albumin and azide were added for stabilization. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Applications
 
WB: 1 : 1000 (AP staining)
IP: yes (see remarks)
ICC: 1 : 100 up to 1 : 500 gallery  
IHC: not tested yet
IHC-P: not tested yet
Label biotin
Clone 108E10
Subtype IgG1 (κ light chain)
Immunogen Recombinant protein corresponding to PDZ-domain of mouse PSD95 (UniProt Id: Q62108)
Reactivity Reacts with: rat (P31016), mouse (Q62108), chicken.
Other species not tested yet.
Specificity Specific for PSD 95. K.O.
Matching control protein/peptide 124-01P
Remarks

IP: For most effective IP use the denaturing SDS based solubilization protocol. Consider that protein-protein interactions may be affected.

Data sheet 124_011bt.pdf

References for PSD95 - 124 011BT

Selective endocytosis of Ca2+-permeable AMPARs by the Alzheimer's disease risk factor CALM bidirectionally controls synaptic plasticity.
Azarnia Tehran D, Kochlamazashvili G, Pampaloni NP, Sposini S, Shergill JK, Lehmann M, Pashkova N, Schmidt C, Löwe D, Napieczynska H, Heuser A, et al.
Science advances (2022) 821: eabl5032. 124 011BT WB; tested species: mouse
Kibra Modulates Learning and Memory via Binding to Dendrin.
Ji Z, Li H, Yang Z, Huang X, Ke X, Ma S, Lin Z, Lu Y, Zhang M
Cell reports (2019) 268: 2064-2077.e7. 124 011BT WB; tested species: mouse
NYX-2925 induces metabotropic NMDAR signaling that enhances synaptic NMDAR and AMPAR.
Bowers MS, Cacheaux LP, Sahu SU, Schmidt ME, Sennello JA, Leaderbrand K, Khan MA, Kroes RA, Moskal JR
Journal of neurochemistry (2019) : . 124 011BT ICC; tested species: rat
Cat. No.: 124 011BT
Amount: 100 µg
Price: $465.00
Selective endocytosis of Ca2+-permeable AMPARs by the Alzheimer's disease risk factor CALM bidirectionally controls synaptic plasticity.
Azarnia Tehran D, Kochlamazashvili G, Pampaloni NP, Sposini S, Shergill JK, Lehmann M, Pashkova N, Schmidt C, Löwe D, Napieczynska H, Heuser A, et al.
Science advances (2022) 821: eabl5032. 124 011BT WB; tested species: mouse
Kibra Modulates Learning and Memory via Binding to Dendrin.
Ji Z, Li H, Yang Z, Huang X, Ke X, Ma S, Lin Z, Lu Y, Zhang M
Cell reports (2019) 268: 2064-2077.e7. 124 011BT WB; tested species: mouse
NYX-2925 induces metabotropic NMDAR signaling that enhances synaptic NMDAR and AMPAR.
Bowers MS, Cacheaux LP, Sahu SU, Schmidt ME, Sennello JA, Leaderbrand K, Khan MA, Kroes RA, Moskal JR
Journal of neurochemistry (2019) : . 124 011BT ICC; tested species: rat
Background

PSD95 (postsynaptic density protein 95 kDa, also called SAP 90: synapse associated protein of 90 kDa and DLG 4) is a component of postsynaptic densities in central synapses. It contains three PDZ domains. The first and second PDZ domain localizes NMDA receptors and K+ channels to synapses, the third binds to neuroligins which are neuronal cell adhesion molecules that interact with β-neurexins and form intercellular junctions. Thus different PDZ domains of PSD 95 might be specialized for distinct functions. Read more: PSD95 single domain antibody