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Home > Products > 124 011

PSD95 antibody PDZ domain - 124 011 K.O.

PSD 95 is a component of postsynaptic densities in central synapses
Mouse monoclonal purified IgG
Cat. No.: 124 011
Amount: 100 µg
Price: $425.00
Cat. No. 124 011 100 µg purified IgG, lyophilized. Albumin and azide were added for stabilization. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 1000 (AP staining) gallery  
IP: yes (see remarks)
ICC: 1 : 100 up to 1 : 500 gallery  
IHC: not tested yet
IHC-P: not tested yet
ExM: 1 : 250 (see remarks) gallery  
Clarity: 1 : 100 (see remarks)
Clone 108E10
Subtype IgG1 (κ light chain)
Immunogen Recombinant protein corresponding to PDZ-domain of mouse PSD95 (UniProt Id: Q62108)
Reactivity Reacts with: rat (P31016), mouse (Q62108), chicken, human (P78352).
Other species not tested yet.
Specificity K.O. validated
Matching control protein/peptide 124-01P
Remarks

IP: For most effective IP use the denaturing SDS based solubilization protocol. Consider that protein-protein interactions may be affected.
ExM: This antibody has been successfully used for the magnified analysis of the proteome (MAP) expansion microscopy method (MAP; Ku et al. 2016. Nature Biotechnology 34:973-981)
Clarity: This antibody has been successfully used for CLARITY application in human brain (Woelfle et al. 2022. bioRxiv)
Data sheet 124_011.pdf

References for PSD95 - 124 011

Orexin induces the production of an endocannabinoid-derived lysophosphatidic acid eliciting hypothalamic synaptic loss in obesity.
Fernández-Rilo AC, Forte N, Palomba L, Tunisi L, Piscitelli F, Imperatore R, Di Costanzo A, Di Marzo V, Cristino L
Molecular metabolism (2023) : 101713. 124 011 WB, IHC; tested species: mouse
Developmental Inhibitory Changes in the Primary Somatosensory Cortex of the Stargazer Mouse Model of Absence Epilepsy.
Hassan M, Grattan DR, Leitch B
Biomolecules (2023) 131: . 124 011 WB; tested species: mouse
Prkn knockout mice show autistic-like behaviors and aberrant synapse formation.
Huo Y, Lu W, Tian Y, Hou Q, Man HY
iScience (2022) 257: 104573. 124 011 WB; tested species: mouse
Dynamic proteomic and phosphoproteomic atlas of corticostriatal axons in neurodevelopment.
Dumrongprechachan V, Salisbury RB, Butler L, MacDonald ML, Kozorovitskiy Y
eLife (2022) 11: . 124 011 WB; tested species: mouse
Vesicular Glutamate Release from Feeder-FreehiPSC-Derived Neurons.
Baldassari S, Cervetto C, Amato S, Fruscione F, Balagura G, Pelassa S, Musante I, Iacomino M, Traverso M, Corradi A, Scudieri P, et al.
International journal of molecular sciences (2022) 2318: . 124 011 WB; tested species: human
Long-term potentiation reconstituted with an artificial TARP/PSD-95 complex.
Ravi AS, Zeng M, Chen X, Sandoval G, Diaz-Alonso J, Zhang M, Nicoll RA
Cell reports (2022) 412: 111483. 124 011 WB; tested species: mouse
Defective lipid signalling caused by mutations in PIK3C2B underlies focal epilepsy.
Gozzelino L, Kochlamazashvili G, Baldassari S, Mackintosh AI, Licchetta L, Iovino E, Liu YC, Bennett CA, Bennett MF, Damiano JA, Zsurka G, et al.
Brain : a journal of neurology (2022) 1457: 2313-2331. 124 011 WB, IHC; tested species: mouse
Activation of the medial preoptic area (MPOA) ameliorates loss of maternal behavior in a Shank2 mouse model for autism.
Grabrucker S, Pagano J, Schweizer J, Urrutia-Ruiz C, Schön M, Thome K, Ehret G, Grabrucker AM, Zhang R, Hengerer B, Bockmann J, et al.
The EMBO journal (2021) : e104267. 124 011 WB; tested species: mouse
SREBP2 gene therapy targeting striatal astrocytes ameliorates Huntington's disease phenotypes.
Birolini G, Verlengia G, Talpo F, Maniezzi C, Zentilin L, Giacca M, Conforti P, Cordiglieri C, Caccia C, Leoni V, Taroni F, et al.
Brain : a journal of neurology (2021) 14410: 3175-3190. 124 011 WB; tested species: mouse
SIRT-1 Activity Sustains Cholesterol Synthesis in the Brain.
Paulazo MA, Sodero AO
Neuroscience (2021) 476: 116-124. 124 011 WB; tested species: mouse
High-content image-based analysis and proteomic profiling identifies Tau phosphorylation inhibitors in a human iPSC-derived glutamatergic neuronal model of tauopathy.
Cheng C, Reis SA, Adams ET, Fass DM, Angus SP, Stuhlmiller TJ, Richardson J, Olafson H, Wang ET, Patnaik D, Beauchamp RL, et al.
Scientific reports (2021) 111: 17029. 124 011 WB; tested species: mouse
Synapsin Condensates Recruit alpha-Synuclein.
Hoffmann C, Sansevrino R, Morabito G, Logan C, Vabulas RM, Ulusoy A, Ganzella M, Milovanovic D
Journal of molecular biology (2021) 43312: 166961. 124 011 WB; tested species: rat
Vesicle Tethering on the Surface of Phase-Separated Active Zone Condensates.
Wu X, Ganzella M, Zhou J, Zhu S, Jahn R, Zhang M
Molecular cell (2020) : . 124 011 WB
Caspr2 interacts with type 1 inositol 1,4,5-trisphosphate receptor in the developing cerebellum and regulates Purkinje cell morphology.
Argent L, Winter F, Prickett I, Carrasquero-Ordaz M, Olsen AL, Kramer H, Lancaster E, Becker EBE
The Journal of biological chemistry (2020) 29536: 12716-12726. 124 011 WB; tested species: mouse
Latrophilin-2 and latrophilin-3 are redundantly essential for parallel-fiber synapse function in cerebellum.
Zhang RS, Liakath-Ali K, Südhof TC
eLife (2020) 9: . 124 011 WB; tested species: mouse
Kir6.1 Heterozygous Mice Exhibit Aberrant Amygdala-Dependent Cued Fear Memory.
Inagaki R, Moriguchi S, Fukunaga K
Molecular neurobiology (2019) : . 124 011 WB; tested species: mouse
Fluoxetine Suppresses Glutamate- and GABA-Mediated Neurotransmission by Altering SNARE Complex.
Lazarevic V, Mantas I, Flais I, Svenningsson P
International journal of molecular sciences (2019) 2017: . 124 011 WB; tested species: rat
Rac1 activation links tau hyperphosphorylation and Aβ dysmetabolism in Alzheimer's disease.
Borin M, Saraceno C, Catania M, Lorenzetto E, Pontelli V, Paterlini A, Fostinelli S, Avesani A, Di Fede G, Zanusso G, Benussi L, et al.
Acta neuropathologica communications (2018) 61: 61. 124 011 WB; tested species: mouse
Neogenin in amygdala for neuronal activity and information processing.
Sun XD, Chen WB, Sun D, Huang J, Li YQ, Pan JX, Wang YN, Zhao K, Dong ZQ, Wang HS, Xiong L, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2018) : . 124 011 WB; tested species: mouse
Mitochondria-Bound Hexokinase (mt-HK) Activity Differ in Cortical and Hypothalamic Synaptosomes: Differential Role of mt-HK in H2O2 Depuration.
Cavalcanti-de-Albuquerque JP, de Souza Ferreira E, de Carvalho DP, Galina A
Molecular neurobiology (2017) : . 124 011 WB; tested species: rat
Proteomic Analysis of Post-synaptic Density Fractions from Shank3 Mutant Mice Reveals Brain Region Specific Changes Relevant to Autism Spectrum Disorder.
Reim D, Distler U, Halbedl S, Verpelli C, Sala C, Bockmann J, Tenzer S, Boeckers TM, Schmeisser MJ
Frontiers in molecular neuroscience (2017) 10: 26. 124 011 WB
PRRT2 Is a Key Component of the Ca(2+)-Dependent Neurotransmitter Release Machinery.
Valente P, Castroflorio E, Rossi P, Fadda M, Sterlini B, Cervigni RI, Prestigio C, Giovedì S, Onofri F, Mura E, Guarnieri FC, et al.
Cell reports (2016) 151: 117-31. 124 011 WB
Mass spectrometric analysis of synaptosomal membrane preparations for the determination of brain receptors, transporters and channels.
Sialana FJ, Gulyassy P, Májek P, Sjöstedt E, Kis V, Müller AC, Rudashevskaya EL, Mulder J, Bennett KL, Lubec G
Proteomics (2016) 1622: 2911-2920. 124 011 WB
Super-Resolution Microscopy Reveals Presynaptic Localization of the ALS/FTD Related Protein FUS in Hippocampal Neurons.
Schoen M, Reichel JM, Demestre M, Putz S, Deshpande D, Proepper C, Liebau S, Schmeisser MJ, Ludolph AC, Michaelis J, Boeckers TM, et al.
Frontiers in cellular neuroscience (2015) 9: 496. 124 011 WB; tested species: rat
Distribution of SNAP25, VAMP1 and VAMP2 in mature and developing deep cerebellar nuclei after estrogen administration.
Manca P, Mameli O, Caria MA, Torrejón-Escribano B, Blasi J
Neuroscience (2014) 266: 102-15. 124 011 IHC, WB
IκB kinase/nuclear factor κB-dependent insulin-like growth factor 2 (Igf2) expression regulates synapse formation and spine maturation via Igf2 receptor signaling.
Schmeisser MJ, Baumann B, Johannsen S, Vindedal GF, Jensen V, Hvalby ØC, Sprengel R, Seither J, Maqbool A, Magnutzki A, Lattke M, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2012) 3216: 5688-703. 124 011 WB; tested species: mouse
Effects of phosphorylation and neuronal activity on the control of synapse formation by synapsin I.
Perlini LE, Botti F, Fornasiero EF, Giannandrea M, Bonanomi D, Amendola M, Naldini L, Benfenati F, Valtorta F
Journal of cell science (2011) 124Pt 21: 3643-53. 124 011 WB
Regulation of Neural Circuit Development by Cadherin-11 Provides Implications for Autism.
Frei JA, Niescier RF, Bridi MS, Durens M, Nestor JE, Kilander MBC, Yuan X, Dykxhoorn DM, Nestor MW, Huang S, Blatt GJ, et al.
eNeuro () 84: . 124 011 WB, ICC; tested species: mouse
Multivesicular release favors short term synaptic depression in hippocampal autapses.
Martínez San Segundo P, Terni B, Llobet A
Frontiers in cellular neuroscience (2023) 17: 1057242. 124 011 ICC; tested species: rat
Extracellular Vesicles Play a Central Role in Cerebral Venous Disease-Associated Brain Atrophy.
Wang JY, Li JY, Luo D, Huang MY, Ao DH, Liu XN, Wang X, Ge W, Zhu YC
Advanced science (Weinheim, Baden-Wurttemberg, Germany) (2023) : e2301574. 124 011 ICC; tested species: rat
Neurexin-2 restricts synapse numbers and restrains the presynaptic release probability by an alternative splicing-dependent mechanism.
Lin PY, Chen LY, Zhou P, Lee SJ, Trotter JH, Südhof TC
Proceedings of the National Academy of Sciences of the United States of America (2023) 12013: e2300363120. 124 011 ICC; tested species: mouse
Presynaptic store-operated Ca2+ entry drives excitatory spontaneous neurotransmission and augments endoplasmic reticulum stress.
Chanaday NL, Nosyreva E, Shin OH, Zhang H, Aklan I, Atasoy D, Bezprozvanny I, Kavalali ET
Neuron (2021) 1098: 1314-1332.e5. 124 011 ICC; tested species: rat
Autism Spectrum Disorder Risk Factor Met Regulates the Organization of Inhibitory Synapses.
Jeckel P, Kriebel M, Volkmer H
Frontiers in molecular neuroscience (2021) 14: 659856. 124 011 ICC; tested species: rat
Latrophilin GPCR signaling mediates synapse formation.
Sando R, Südhof TC
eLife (2021) 10: . 124 011 ICC; tested species: mouse
Allosteric modulation of NMDA receptors prevents the antibody effects of patients with anti-NMDAR encephalitis.
Mannara F, Radosevic M, Planagumà J, Soto D, Aguilar E, García-Serra A, Maudes E, Pedreño M, Paul S, Doherty J, Quirk M, et al.
Brain : a journal of neurology (2020) : . 124 011 ICC, IHC; tested species: mouse
VAMP4 maintains a Ca2+-sensitive pool of spontaneously recycling synaptic vesicles.
Lin PY, Chanaday NL, Horvath PM, Ramirez DMO, Monteggia LM, Kavalali ET
The Journal of neuroscience : the official journal of the Society for Neuroscience (2020) : . 124 011 ICC; tested species: rat
Neuronal Inactivity Co-opts LTP Machinery to Drive Potassium Channel Splicing and Homeostatic Spike Widening.
Li B, Suutari BS, Sun SD, Luo Z, Wei C, Chenouard N, Mandelberg NJ, Zhang G, Wamsley B, Tian G, Sanchez S, et al.
Cell (2020) : . 124 011 ICC; tested species: rat
Alternative splicing controls teneurin-latrophilin interaction and synapse specificity by a shape-shifting mechanism.
Li J, Xie Y, Cornelius S, Jiang X, Sando R, Kordon SP, Pan M, Leon K, Südhof TC, Zhao M, Araç D, et al.
Nature communications (2020) 111: 2140. 124 011 ICC; tested species: mouse
The ubiquitin-proteasome system functionally links neuronal Tomosyn-1 to dendritic morphology.
Saldate JJ, Shiau J, Cazares VA, Stuenkel EL
The Journal of biological chemistry (2018) 2937: 2232-2246. 124 011 ICC; tested species: rat
Structural Basis for Teneurin Function in Circuit-Wiring: A Toxin Motif at the Synapse.
Li J, Shalev-Benami M, Sando R, Jiang X, Kibrom A, Wang J, Leon K, Katanski C, Nazarko O, Lu YC, Südhof TC, et al.
Cell (2018) 1733: 735-748.e15. 124 011 ICC; tested species: mouse
Vti1a/b regulate synaptic vesicle and dense core vesicle secretion via protein sorting at the Golgi.
Emperador-Melero J, Huson V, van Weering J, Bollmann C, Fischer von Mollard G, Toonen RF, Verhage M
Nature communications (2018) 91: 3421. 124 011 ICC; tested species: mouse
Riluzole attenuates the efficacy of glutamatergic transmission by interfering with the size of the readily releasable neurotransmitter pool.
Lazarevic V, Yang Y, Ivanova D, Fejtova A, Svenningsson P
Neuropharmacology (2018) : . 124 011 ICC; tested species: rat
Synaptic Vesicle Endocytosis Occurs on Multiple Timescales and Is Mediated by Formin-Dependent Actin Assembly.
Soykan T, Kaempf N, Sakaba T, Vollweiter D, Goerdeler F, Puchkov D, Kononenko NL, Haucke V
Neuron (2017) 934: 854-866.e4. 124 011 ICC; tested species: mouse
Assay of Calcium Transients and Synapses in Rat Hippocampal Neurons by Kinetic Image Cytometry and High-Content Analysis: An In Vitro Model System for Postchemotherapy Cognitive Impairment.
McDonough PM, Prigozhina NL, Basa RCB, Price JH
Assay and drug development technologies (2017) 155: 220-236. 124 011 ICC; tested species: rat
Neuronal hyperactivity causes Na+/H+ exchanger-induced extracellular acidification at active synapses.
Chiacchiaretta M, Latifi S, Bramini M, Fadda M, Fassio A, Benfenati F, Cesca F
Journal of cell science (2017) 1308: 1435-1449. 124 011 ICC; tested species: mouse
Long-term primary culture of neurons taken from chick embryo brain: A model to study neural cell biology, synaptogenesis and its dynamic properties.
Kumar A, Mallick BN
Journal of neuroscience methods (2016) 263: 123-33. 124 011 ICC; tested species: chicken
The effects of proteasomal inhibition on synaptic proteostasis.
Hakim V, Cohen LD, Zuchman R, Ziv T, Ziv NE
The EMBO journal (2016) 3520: 2238-2262. 124 011 ICC
Fibroblast growth factor 23 signaling in hippocampal cells: impact on neuronal morphology and synaptic density.
Hensel N, Schön A, Konen T, Lübben V, Förthmann B, Baron O, Grothe C, Leifheit-Nestler M, Claus P, Haffner D
Journal of neurochemistry (2016) 1375: 756-69. 124 011 ICC
Endogenous APP accumulates in synapses after BACE1 inhibition.
Nigam SM, Xu S, Ackermann F, Gregory JA, Lundkvist J, Lendahl U, Brodin L
Neuroscience research (2016) 109: 9-15. 124 011 ICC
Reduced SNAP-25 increases PSD-95 mobility and impairs spine morphogenesis.
Fossati G, Morini R, Corradini I, Antonucci F, Trepte P, Edry E, Sharma V, Papale A, Pozzi D, Defilippi P, Meier JC, et al.
Cell death and differentiation (2015) 229: 1425-36. 124 011 ICC
Neuronal activity-dependent STAT3 localization to nucleus is dependent on Tyr-705 and Ser-727 phosphorylation in rat hippocampal neurons.
Murase S, McKay RD
The European journal of neuroscience (2014) 394: 557-65. 124 011 ICC; tested species: rat
Metabolic turnover of synaptic proteins: kinetics, interdependencies and implications for synaptic maintenance.
Cohen LD, Zuchman R, Sorokina O, Müller A, Dieterich DC, Armstrong JD, Ziv T, Ziv NE
PloS one (2013) 85: e63191. 124 011 ICC; tested species: rat
Regulation of Neural Circuit Development by Cadherin-11 Provides Implications for Autism.
Frei JA, Niescier RF, Bridi MS, Durens M, Nestor JE, Kilander MBC, Yuan X, Dykxhoorn DM, Nestor MW, Huang S, Blatt GJ, et al.
eNeuro () 84: . 124 011 WB, ICC; tested species: mouse
Botulinum neurotoxin A ameliorates depressive-like behavior in a reserpine-induced Parkinson's disease mouse model via suppressing hippocampal microglial engulfment and neuroinflammation.
Li Y, Yin Q, Li Q, Huo AR, Shen TT, Cao JQ, Liu CF, Liu T, Luo WF, Cong QF
Acta pharmacologica Sinica (2023) 447: 1322-1336. 124 011 IHC; tested species: mouse
Orexin induces the production of an endocannabinoid-derived lysophosphatidic acid eliciting hypothalamic synaptic loss in obesity.
Fernández-Rilo AC, Forte N, Palomba L, Tunisi L, Piscitelli F, Imperatore R, Di Costanzo A, Di Marzo V, Cristino L
Molecular metabolism (2023) : 101713. 124 011 WB, IHC; tested species: mouse
SOX2 is essential for astrocyte maturation and its deletion leads to hyperactive behavior in mice.
Wang Y, Zhang S, Lan Z, Doan V, Kim B, Liu S, Zhu M, Hull VL, Rihani S, Zhang CL, Gray JA, et al.
Cell reports (2022) 4112: 111842. 124 011 IHC; tested species: mouse
Defective lipid signalling caused by mutations in PIK3C2B underlies focal epilepsy.
Gozzelino L, Kochlamazashvili G, Baldassari S, Mackintosh AI, Licchetta L, Iovino E, Liu YC, Bennett CA, Bennett MF, Damiano JA, Zsurka G, et al.
Brain : a journal of neurology (2022) 1457: 2313-2331. 124 011 WB, IHC; tested species: mouse
Orexin-A and endocannabinoids are involved in obesity-associated alteration of hippocampal neurogenesis, plasticity, and episodic memory in mice.
Forte N, Boccella S, Tunisi L, Fernández-Rilo AC, Imperatore R, Iannotti FA, De Risi M, Iannotta M, Piscitelli F, Capasso R, De Girolamo P, et al.
Nature communications (2021) 121: 6137. 124 011 IHC; tested species: mouse
Allosteric modulation of NMDA receptors prevents the antibody effects of patients with anti-NMDAR encephalitis.
Mannara F, Radosevic M, Planagumà J, Soto D, Aguilar E, García-Serra A, Maudes E, Pedreño M, Paul S, Doherty J, Quirk M, et al.
Brain : a journal of neurology (2020) : . 124 011 ICC, IHC; tested species: mouse
Localization of group II and III metabotropic glutamate receptors at pre- and postsynaptic sites of inner hair cell ribbon synapses.
Klotz L, Wendler O, Frischknecht R, Shigemoto R, Schulze H, Enz R
FASEB journal : official publication of the Federation of American Societies for Experimental Biology (2019) : fj201901543R. 124 011 IHC; tested species: mouse
Re-evaluation of neuronal P2X7 expression using novel mouse models and a P2X7-specific nanobody.
Kaczmarek-Hajek K, Zhang J, Kopp R, Grosche A, Rissiek B, Saul A, Bruzzone S, Engel T, Jooss T, Krautloher A, Schuster S, et al.
eLife (2018) 7: . 124 011 IHC; tested species: mouse
Distribution of SNAP25, VAMP1 and VAMP2 in mature and developing deep cerebellar nuclei after estrogen administration.
Manca P, Mameli O, Caria MA, Torrejón-Escribano B, Blasi J
Neuroscience (2014) 266: 102-15. 124 011 IHC, WB
Computerized EEG in the comparison of oxyprothepin and fluphenazine decanoat.
Misurec J, Náhunek K, Svestka J, Cesková E
Activitas nervosa superior (1979) 213: 140. 124 011 Clarity; tested species: human
Cat. No.: 124 011
Amount: 100 µg
Price: $425.00
Orexin induces the production of an endocannabinoid-derived lysophosphatidic acid eliciting hypothalamic synaptic loss in obesity.
Fernández-Rilo AC, Forte N, Palomba L, Tunisi L, Piscitelli F, Imperatore R, Di Costanzo A, Di Marzo V, Cristino L
Molecular metabolism (2023) : 101713. 124 011 WB, IHC; tested species: mouse
Developmental Inhibitory Changes in the Primary Somatosensory Cortex of the Stargazer Mouse Model of Absence Epilepsy.
Hassan M, Grattan DR, Leitch B
Biomolecules (2023) 131: . 124 011 WB; tested species: mouse
Prkn knockout mice show autistic-like behaviors and aberrant synapse formation.
Huo Y, Lu W, Tian Y, Hou Q, Man HY
iScience (2022) 257: 104573. 124 011 WB; tested species: mouse
Dynamic proteomic and phosphoproteomic atlas of corticostriatal axons in neurodevelopment.
Dumrongprechachan V, Salisbury RB, Butler L, MacDonald ML, Kozorovitskiy Y
eLife (2022) 11: . 124 011 WB; tested species: mouse
Vesicular Glutamate Release from Feeder-FreehiPSC-Derived Neurons.
Baldassari S, Cervetto C, Amato S, Fruscione F, Balagura G, Pelassa S, Musante I, Iacomino M, Traverso M, Corradi A, Scudieri P, et al.
International journal of molecular sciences (2022) 2318: . 124 011 WB; tested species: human
Long-term potentiation reconstituted with an artificial TARP/PSD-95 complex.
Ravi AS, Zeng M, Chen X, Sandoval G, Diaz-Alonso J, Zhang M, Nicoll RA
Cell reports (2022) 412: 111483. 124 011 WB; tested species: mouse
Defective lipid signalling caused by mutations in PIK3C2B underlies focal epilepsy.
Gozzelino L, Kochlamazashvili G, Baldassari S, Mackintosh AI, Licchetta L, Iovino E, Liu YC, Bennett CA, Bennett MF, Damiano JA, Zsurka G, et al.
Brain : a journal of neurology (2022) 1457: 2313-2331. 124 011 WB, IHC; tested species: mouse
Activation of the medial preoptic area (MPOA) ameliorates loss of maternal behavior in a Shank2 mouse model for autism.
Grabrucker S, Pagano J, Schweizer J, Urrutia-Ruiz C, Schön M, Thome K, Ehret G, Grabrucker AM, Zhang R, Hengerer B, Bockmann J, et al.
The EMBO journal (2021) : e104267. 124 011 WB; tested species: mouse
SREBP2 gene therapy targeting striatal astrocytes ameliorates Huntington's disease phenotypes.
Birolini G, Verlengia G, Talpo F, Maniezzi C, Zentilin L, Giacca M, Conforti P, Cordiglieri C, Caccia C, Leoni V, Taroni F, et al.
Brain : a journal of neurology (2021) 14410: 3175-3190. 124 011 WB; tested species: mouse
SIRT-1 Activity Sustains Cholesterol Synthesis in the Brain.
Paulazo MA, Sodero AO
Neuroscience (2021) 476: 116-124. 124 011 WB; tested species: mouse
High-content image-based analysis and proteomic profiling identifies Tau phosphorylation inhibitors in a human iPSC-derived glutamatergic neuronal model of tauopathy.
Cheng C, Reis SA, Adams ET, Fass DM, Angus SP, Stuhlmiller TJ, Richardson J, Olafson H, Wang ET, Patnaik D, Beauchamp RL, et al.
Scientific reports (2021) 111: 17029. 124 011 WB; tested species: mouse
Synapsin Condensates Recruit alpha-Synuclein.
Hoffmann C, Sansevrino R, Morabito G, Logan C, Vabulas RM, Ulusoy A, Ganzella M, Milovanovic D
Journal of molecular biology (2021) 43312: 166961. 124 011 WB; tested species: rat
Vesicle Tethering on the Surface of Phase-Separated Active Zone Condensates.
Wu X, Ganzella M, Zhou J, Zhu S, Jahn R, Zhang M
Molecular cell (2020) : . 124 011 WB
Caspr2 interacts with type 1 inositol 1,4,5-trisphosphate receptor in the developing cerebellum and regulates Purkinje cell morphology.
Argent L, Winter F, Prickett I, Carrasquero-Ordaz M, Olsen AL, Kramer H, Lancaster E, Becker EBE
The Journal of biological chemistry (2020) 29536: 12716-12726. 124 011 WB; tested species: mouse
Latrophilin-2 and latrophilin-3 are redundantly essential for parallel-fiber synapse function in cerebellum.
Zhang RS, Liakath-Ali K, Südhof TC
eLife (2020) 9: . 124 011 WB; tested species: mouse
Kir6.1 Heterozygous Mice Exhibit Aberrant Amygdala-Dependent Cued Fear Memory.
Inagaki R, Moriguchi S, Fukunaga K
Molecular neurobiology (2019) : . 124 011 WB; tested species: mouse
Fluoxetine Suppresses Glutamate- and GABA-Mediated Neurotransmission by Altering SNARE Complex.
Lazarevic V, Mantas I, Flais I, Svenningsson P
International journal of molecular sciences (2019) 2017: . 124 011 WB; tested species: rat
Rac1 activation links tau hyperphosphorylation and Aβ dysmetabolism in Alzheimer's disease.
Borin M, Saraceno C, Catania M, Lorenzetto E, Pontelli V, Paterlini A, Fostinelli S, Avesani A, Di Fede G, Zanusso G, Benussi L, et al.
Acta neuropathologica communications (2018) 61: 61. 124 011 WB; tested species: mouse
Neogenin in amygdala for neuronal activity and information processing.
Sun XD, Chen WB, Sun D, Huang J, Li YQ, Pan JX, Wang YN, Zhao K, Dong ZQ, Wang HS, Xiong L, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2018) : . 124 011 WB; tested species: mouse
Mitochondria-Bound Hexokinase (mt-HK) Activity Differ in Cortical and Hypothalamic Synaptosomes: Differential Role of mt-HK in H2O2 Depuration.
Cavalcanti-de-Albuquerque JP, de Souza Ferreira E, de Carvalho DP, Galina A
Molecular neurobiology (2017) : . 124 011 WB; tested species: rat
Proteomic Analysis of Post-synaptic Density Fractions from Shank3 Mutant Mice Reveals Brain Region Specific Changes Relevant to Autism Spectrum Disorder.
Reim D, Distler U, Halbedl S, Verpelli C, Sala C, Bockmann J, Tenzer S, Boeckers TM, Schmeisser MJ
Frontiers in molecular neuroscience (2017) 10: 26. 124 011 WB
PRRT2 Is a Key Component of the Ca(2+)-Dependent Neurotransmitter Release Machinery.
Valente P, Castroflorio E, Rossi P, Fadda M, Sterlini B, Cervigni RI, Prestigio C, Giovedì S, Onofri F, Mura E, Guarnieri FC, et al.
Cell reports (2016) 151: 117-31. 124 011 WB
Mass spectrometric analysis of synaptosomal membrane preparations for the determination of brain receptors, transporters and channels.
Sialana FJ, Gulyassy P, Májek P, Sjöstedt E, Kis V, Müller AC, Rudashevskaya EL, Mulder J, Bennett KL, Lubec G
Proteomics (2016) 1622: 2911-2920. 124 011 WB
Super-Resolution Microscopy Reveals Presynaptic Localization of the ALS/FTD Related Protein FUS in Hippocampal Neurons.
Schoen M, Reichel JM, Demestre M, Putz S, Deshpande D, Proepper C, Liebau S, Schmeisser MJ, Ludolph AC, Michaelis J, Boeckers TM, et al.
Frontiers in cellular neuroscience (2015) 9: 496. 124 011 WB; tested species: rat
Distribution of SNAP25, VAMP1 and VAMP2 in mature and developing deep cerebellar nuclei after estrogen administration.
Manca P, Mameli O, Caria MA, Torrejón-Escribano B, Blasi J
Neuroscience (2014) 266: 102-15. 124 011 IHC, WB
IκB kinase/nuclear factor κB-dependent insulin-like growth factor 2 (Igf2) expression regulates synapse formation and spine maturation via Igf2 receptor signaling.
Schmeisser MJ, Baumann B, Johannsen S, Vindedal GF, Jensen V, Hvalby ØC, Sprengel R, Seither J, Maqbool A, Magnutzki A, Lattke M, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2012) 3216: 5688-703. 124 011 WB; tested species: mouse
Effects of phosphorylation and neuronal activity on the control of synapse formation by synapsin I.
Perlini LE, Botti F, Fornasiero EF, Giannandrea M, Bonanomi D, Amendola M, Naldini L, Benfenati F, Valtorta F
Journal of cell science (2011) 124Pt 21: 3643-53. 124 011 WB
Regulation of Neural Circuit Development by Cadherin-11 Provides Implications for Autism.
Frei JA, Niescier RF, Bridi MS, Durens M, Nestor JE, Kilander MBC, Yuan X, Dykxhoorn DM, Nestor MW, Huang S, Blatt GJ, et al.
eNeuro () 84: . 124 011 WB, ICC; tested species: mouse
Multivesicular release favors short term synaptic depression in hippocampal autapses.
Martínez San Segundo P, Terni B, Llobet A
Frontiers in cellular neuroscience (2023) 17: 1057242. 124 011 ICC; tested species: rat
Extracellular Vesicles Play a Central Role in Cerebral Venous Disease-Associated Brain Atrophy.
Wang JY, Li JY, Luo D, Huang MY, Ao DH, Liu XN, Wang X, Ge W, Zhu YC
Advanced science (Weinheim, Baden-Wurttemberg, Germany) (2023) : e2301574. 124 011 ICC; tested species: rat
Neurexin-2 restricts synapse numbers and restrains the presynaptic release probability by an alternative splicing-dependent mechanism.
Lin PY, Chen LY, Zhou P, Lee SJ, Trotter JH, Südhof TC
Proceedings of the National Academy of Sciences of the United States of America (2023) 12013: e2300363120. 124 011 ICC; tested species: mouse
Presynaptic store-operated Ca2+ entry drives excitatory spontaneous neurotransmission and augments endoplasmic reticulum stress.
Chanaday NL, Nosyreva E, Shin OH, Zhang H, Aklan I, Atasoy D, Bezprozvanny I, Kavalali ET
Neuron (2021) 1098: 1314-1332.e5. 124 011 ICC; tested species: rat
Autism Spectrum Disorder Risk Factor Met Regulates the Organization of Inhibitory Synapses.
Jeckel P, Kriebel M, Volkmer H
Frontiers in molecular neuroscience (2021) 14: 659856. 124 011 ICC; tested species: rat
Latrophilin GPCR signaling mediates synapse formation.
Sando R, Südhof TC
eLife (2021) 10: . 124 011 ICC; tested species: mouse
Allosteric modulation of NMDA receptors prevents the antibody effects of patients with anti-NMDAR encephalitis.
Mannara F, Radosevic M, Planagumà J, Soto D, Aguilar E, García-Serra A, Maudes E, Pedreño M, Paul S, Doherty J, Quirk M, et al.
Brain : a journal of neurology (2020) : . 124 011 ICC, IHC; tested species: mouse
VAMP4 maintains a Ca2+-sensitive pool of spontaneously recycling synaptic vesicles.
Lin PY, Chanaday NL, Horvath PM, Ramirez DMO, Monteggia LM, Kavalali ET
The Journal of neuroscience : the official journal of the Society for Neuroscience (2020) : . 124 011 ICC; tested species: rat
Neuronal Inactivity Co-opts LTP Machinery to Drive Potassium Channel Splicing and Homeostatic Spike Widening.
Li B, Suutari BS, Sun SD, Luo Z, Wei C, Chenouard N, Mandelberg NJ, Zhang G, Wamsley B, Tian G, Sanchez S, et al.
Cell (2020) : . 124 011 ICC; tested species: rat
Alternative splicing controls teneurin-latrophilin interaction and synapse specificity by a shape-shifting mechanism.
Li J, Xie Y, Cornelius S, Jiang X, Sando R, Kordon SP, Pan M, Leon K, Südhof TC, Zhao M, Araç D, et al.
Nature communications (2020) 111: 2140. 124 011 ICC; tested species: mouse
The ubiquitin-proteasome system functionally links neuronal Tomosyn-1 to dendritic morphology.
Saldate JJ, Shiau J, Cazares VA, Stuenkel EL
The Journal of biological chemistry (2018) 2937: 2232-2246. 124 011 ICC; tested species: rat
Structural Basis for Teneurin Function in Circuit-Wiring: A Toxin Motif at the Synapse.
Li J, Shalev-Benami M, Sando R, Jiang X, Kibrom A, Wang J, Leon K, Katanski C, Nazarko O, Lu YC, Südhof TC, et al.
Cell (2018) 1733: 735-748.e15. 124 011 ICC; tested species: mouse
Vti1a/b regulate synaptic vesicle and dense core vesicle secretion via protein sorting at the Golgi.
Emperador-Melero J, Huson V, van Weering J, Bollmann C, Fischer von Mollard G, Toonen RF, Verhage M
Nature communications (2018) 91: 3421. 124 011 ICC; tested species: mouse
Riluzole attenuates the efficacy of glutamatergic transmission by interfering with the size of the readily releasable neurotransmitter pool.
Lazarevic V, Yang Y, Ivanova D, Fejtova A, Svenningsson P
Neuropharmacology (2018) : . 124 011 ICC; tested species: rat
Synaptic Vesicle Endocytosis Occurs on Multiple Timescales and Is Mediated by Formin-Dependent Actin Assembly.
Soykan T, Kaempf N, Sakaba T, Vollweiter D, Goerdeler F, Puchkov D, Kononenko NL, Haucke V
Neuron (2017) 934: 854-866.e4. 124 011 ICC; tested species: mouse
Assay of Calcium Transients and Synapses in Rat Hippocampal Neurons by Kinetic Image Cytometry and High-Content Analysis: An In Vitro Model System for Postchemotherapy Cognitive Impairment.
McDonough PM, Prigozhina NL, Basa RCB, Price JH
Assay and drug development technologies (2017) 155: 220-236. 124 011 ICC; tested species: rat
Neuronal hyperactivity causes Na+/H+ exchanger-induced extracellular acidification at active synapses.
Chiacchiaretta M, Latifi S, Bramini M, Fadda M, Fassio A, Benfenati F, Cesca F
Journal of cell science (2017) 1308: 1435-1449. 124 011 ICC; tested species: mouse
Long-term primary culture of neurons taken from chick embryo brain: A model to study neural cell biology, synaptogenesis and its dynamic properties.
Kumar A, Mallick BN
Journal of neuroscience methods (2016) 263: 123-33. 124 011 ICC; tested species: chicken
The effects of proteasomal inhibition on synaptic proteostasis.
Hakim V, Cohen LD, Zuchman R, Ziv T, Ziv NE
The EMBO journal (2016) 3520: 2238-2262. 124 011 ICC
Fibroblast growth factor 23 signaling in hippocampal cells: impact on neuronal morphology and synaptic density.
Hensel N, Schön A, Konen T, Lübben V, Förthmann B, Baron O, Grothe C, Leifheit-Nestler M, Claus P, Haffner D
Journal of neurochemistry (2016) 1375: 756-69. 124 011 ICC
Endogenous APP accumulates in synapses after BACE1 inhibition.
Nigam SM, Xu S, Ackermann F, Gregory JA, Lundkvist J, Lendahl U, Brodin L
Neuroscience research (2016) 109: 9-15. 124 011 ICC
Reduced SNAP-25 increases PSD-95 mobility and impairs spine morphogenesis.
Fossati G, Morini R, Corradini I, Antonucci F, Trepte P, Edry E, Sharma V, Papale A, Pozzi D, Defilippi P, Meier JC, et al.
Cell death and differentiation (2015) 229: 1425-36. 124 011 ICC
Neuronal activity-dependent STAT3 localization to nucleus is dependent on Tyr-705 and Ser-727 phosphorylation in rat hippocampal neurons.
Murase S, McKay RD
The European journal of neuroscience (2014) 394: 557-65. 124 011 ICC; tested species: rat
Metabolic turnover of synaptic proteins: kinetics, interdependencies and implications for synaptic maintenance.
Cohen LD, Zuchman R, Sorokina O, Müller A, Dieterich DC, Armstrong JD, Ziv T, Ziv NE
PloS one (2013) 85: e63191. 124 011 ICC; tested species: rat
Regulation of Neural Circuit Development by Cadherin-11 Provides Implications for Autism.
Frei JA, Niescier RF, Bridi MS, Durens M, Nestor JE, Kilander MBC, Yuan X, Dykxhoorn DM, Nestor MW, Huang S, Blatt GJ, et al.
eNeuro () 84: . 124 011 WB, ICC; tested species: mouse
Botulinum neurotoxin A ameliorates depressive-like behavior in a reserpine-induced Parkinson's disease mouse model via suppressing hippocampal microglial engulfment and neuroinflammation.
Li Y, Yin Q, Li Q, Huo AR, Shen TT, Cao JQ, Liu CF, Liu T, Luo WF, Cong QF
Acta pharmacologica Sinica (2023) 447: 1322-1336. 124 011 IHC; tested species: mouse
Orexin induces the production of an endocannabinoid-derived lysophosphatidic acid eliciting hypothalamic synaptic loss in obesity.
Fernández-Rilo AC, Forte N, Palomba L, Tunisi L, Piscitelli F, Imperatore R, Di Costanzo A, Di Marzo V, Cristino L
Molecular metabolism (2023) : 101713. 124 011 WB, IHC; tested species: mouse
SOX2 is essential for astrocyte maturation and its deletion leads to hyperactive behavior in mice.
Wang Y, Zhang S, Lan Z, Doan V, Kim B, Liu S, Zhu M, Hull VL, Rihani S, Zhang CL, Gray JA, et al.
Cell reports (2022) 4112: 111842. 124 011 IHC; tested species: mouse
Defective lipid signalling caused by mutations in PIK3C2B underlies focal epilepsy.
Gozzelino L, Kochlamazashvili G, Baldassari S, Mackintosh AI, Licchetta L, Iovino E, Liu YC, Bennett CA, Bennett MF, Damiano JA, Zsurka G, et al.
Brain : a journal of neurology (2022) 1457: 2313-2331. 124 011 WB, IHC; tested species: mouse
Orexin-A and endocannabinoids are involved in obesity-associated alteration of hippocampal neurogenesis, plasticity, and episodic memory in mice.
Forte N, Boccella S, Tunisi L, Fernández-Rilo AC, Imperatore R, Iannotti FA, De Risi M, Iannotta M, Piscitelli F, Capasso R, De Girolamo P, et al.
Nature communications (2021) 121: 6137. 124 011 IHC; tested species: mouse
Allosteric modulation of NMDA receptors prevents the antibody effects of patients with anti-NMDAR encephalitis.
Mannara F, Radosevic M, Planagumà J, Soto D, Aguilar E, García-Serra A, Maudes E, Pedreño M, Paul S, Doherty J, Quirk M, et al.
Brain : a journal of neurology (2020) : . 124 011 ICC, IHC; tested species: mouse
Localization of group II and III metabotropic glutamate receptors at pre- and postsynaptic sites of inner hair cell ribbon synapses.
Klotz L, Wendler O, Frischknecht R, Shigemoto R, Schulze H, Enz R
FASEB journal : official publication of the Federation of American Societies for Experimental Biology (2019) : fj201901543R. 124 011 IHC; tested species: mouse
Re-evaluation of neuronal P2X7 expression using novel mouse models and a P2X7-specific nanobody.
Kaczmarek-Hajek K, Zhang J, Kopp R, Grosche A, Rissiek B, Saul A, Bruzzone S, Engel T, Jooss T, Krautloher A, Schuster S, et al.
eLife (2018) 7: . 124 011 IHC; tested species: mouse
Distribution of SNAP25, VAMP1 and VAMP2 in mature and developing deep cerebellar nuclei after estrogen administration.
Manca P, Mameli O, Caria MA, Torrejón-Escribano B, Blasi J
Neuroscience (2014) 266: 102-15. 124 011 IHC, WB
Computerized EEG in the comparison of oxyprothepin and fluphenazine decanoat.
Misurec J, Náhunek K, Svestka J, Cesková E
Activitas nervosa superior (1979) 213: 140. 124 011 Clarity; tested species: human
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Background

PSD 95 (postsynaptic density protein 95 kDa, also called SAP 90: synapse associated protein of 90 kDa and DLG 4) is a component of postsynaptic densities in central synapses. It contains three PDZ domains. The first and second PDZ domain localizes NMDA receptors and K+ channels to synapses, the third binds to neuroligins which are neuronal cell adhesion molecules that interact with β-neurexins and form intercellular junctions. Thus different PDZ domains of PSD 95 might be specialized for distinct functions.
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