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PSD95 antibody PDZ domain - 124 014

PSD 95 is a component of postsynaptic densities in central synapses
Guinea pig polyclonal antiserum
Cat. No.: 124 014
Amount: 100 µl
Price: $375.00
Cat. No. 124 014 100 µl antiserum, lyophilized. For reconstitution add 100 µl H2O, then aliquot and store at -20°C until use.
Applications
 
WB: 1 : 1000 up to 1 : 10000 (AP staining) gallery  
IP: not tested yet
ICC: 1 : 1000 up to 1 : 3000 (see remarks) gallery  
IHC: not tested yet
IHC-P/FFPE: not tested yet
Immunogen Recombinant protein corresponding to AA 68 to 251 from mouse PSD95 (UniProt Id: Q62108)
Reactivity Reacts with: rat (P31016), mouse (Q62108).
Other species not tested yet.
Specificity Specific for PSD 95 with weak cross-reactivity to SAP 102
Matching control protein/peptide 124-01P
Remarks

ICC: Produces more background staining than the monoclonal antibody cat. no. 124 011.

Data sheet 124_014.pdf

References for PSD95 - 124 014

Neuronal Autophagy Regulates Presynaptic Neurotransmission by Controlling the Axonal Endoplasmic Reticulum.
Kuijpers M, Kochlamazashvili G, Stumpf A, Puchkov D, Swaminathan A, Lucht MT, Krause E, Maritzen T, Schmitz D, Haucke V
Neuron (2021) 1092: 299-313.e9. 124 014 WB; tested species: mouse
Estradiol reverses excitatory synapse loss in a cellular model of neuropsychiatric disorders.
Erli F, Palmos AB, Raval P, Mukherjee J, Sellers KJ, Gatford NJF, Moss SJ, Brandon NJ, Penzes P, Srivastava DP
Translational psychiatry (2020) 101: 16. 124 014 WB, ICC; tested species: rat
Changes in synaptic proteins precede neurodegeneration markers in preclinical Alzheimer's disease cerebrospinal fluid.
Lleó A, Núñez-Llaves R, Alcolea D, Chiva C, Balateu-Paños D, Colom-Cadena M, Gomez-Giro G, Muñoz L, Querol-Vilaseca M, Pegueroles J, Rami L, et al.
Molecular & cellular proteomics : MCP (2019) : . 124 014 WB; tested species: human
Tau is required for the function of extrasynaptic NMDA receptors.
Pallas-Bazarra N, Draffin J, Cuadros R, Antonio Esteban J, Avila J
Scientific reports (2019) 91: 9116. 124 014 WB, IHC; tested species: mouse
The X-Linked Intellectual Disability Gene Zdhhc9 Is Essential for Dendrite Outgrowth and Inhibitory Synapse Formation.
Shimell JJ, Shah BS, Cain SM, Thouta S, Kuhlmann N, Tatarnikov I, Jovellar DB, Brigidi GS, Kass J, Milnerwood AJ, Snutch TP, et al.
Cell reports (2019) 298: 2422-2437.e8. 124 014 WB, ICC; tested species: rat
Piperlongumine decreases cognitive impairment and improves hippocampal function in aged mice.
Go J, Park TS, Han GH, Park HY, Ryu YK, Kim YH, Hwang JH, Choi DH, Noh JR, Hwang DY, Kim S, et al.
International journal of molecular medicine (2018) 424: 1875-1884. 124 014 WB; tested species: mouse
Estradiol reverses excitatory synapse loss in a cellular model of neuropsychiatric disorders.
Erli F, Palmos AB, Raval P, Mukherjee J, Sellers KJ, Gatford NJF, Moss SJ, Brandon NJ, Penzes P, Srivastava DP
Translational psychiatry (2020) 101: 16. 124 014 WB, ICC; tested species: rat
The X-Linked Intellectual Disability Gene Zdhhc9 Is Essential for Dendrite Outgrowth and Inhibitory Synapse Formation.
Shimell JJ, Shah BS, Cain SM, Thouta S, Kuhlmann N, Tatarnikov I, Jovellar DB, Brigidi GS, Kass J, Milnerwood AJ, Snutch TP, et al.
Cell reports (2019) 298: 2422-2437.e8. 124 014 WB, ICC; tested species: rat
Knockout of Amyloid β Protein Precursor (APP) Expression Alters Synaptogenesis, Neurite Branching and Axonal Morphology of Hippocampal Neurons.
Southam KA, Stennard F, Pavez C, Small DH
Neurochemical research (2018) : . 124 014 ICC; tested species: mouse
Variability in the Munc13-1 content of excitatory release sites.
Karlocai MR, Heredi J, Benedek T, Holderith N, Lorincz A, Nusser Z
eLife (2021) 10: . 124 014 IHC, EM; tested species: mouse
A High-Resolution Method for Quantitative Molecular Analysis of Functionally Characterized Individual Synapses.
Holderith N, Heredi J, Kis V, Nusser Z
Cell reports (2020) 324: 107968. 124 014 IHC; tested species: rat
Tau is required for the function of extrasynaptic NMDA receptors.
Pallas-Bazarra N, Draffin J, Cuadros R, Antonio Esteban J, Avila J
Scientific reports (2019) 91: 9116. 124 014 WB, IHC; tested species: mouse
Opposing Roles of apolipoprotein E in aging and neurodegeneration.
Hudry E, Klickstein J, Cannavo C, Jackson R, Muzikansky A, Gandhi S, Urick D, Sargent T, Wrobleski L, Roe AD, Hou SS, et al.
Life science alliance (2019) 21: . 124 014 IHC; tested species: mouse
MicroRNA-mediated disruption of dendritogenesis during a critical period of development influences cognitive capacity later in life.
Lin Q, Ponnusamy R, Widagdo J, Choi JA, Ge W, Probst C, Buckley T, Lou M, Bredy TW, Fanselow MS, Ye K, et al.
Proceedings of the National Academy of Sciences of the United States of America (2017) 11434: 9188-9193. 124 014 IHC; tested species: mouse
Synapse loss in the prefrontal cortex is associated with cognitive decline in amyotrophic lateral sclerosis.
Henstridge CM, Sideris DI, Carroll E, Rotariu S, Salomonsson S, Tzioras M, McKenzie CA, Smith C, von Arnim CAF, Ludolph AC, Lulé D, et al.
Acta neuropathologica (2018) 1352: 213-226. 124 014 IHC-P; tested species: human
Variability in the Munc13-1 content of excitatory release sites.
Karlocai MR, Heredi J, Benedek T, Holderith N, Lorincz A, Nusser Z
eLife (2021) 10: . 124 014 IHC, EM; tested species: mouse
Cat. No.: 124 014
Amount: 100 µl
Price: $375.00
Neuronal Autophagy Regulates Presynaptic Neurotransmission by Controlling the Axonal Endoplasmic Reticulum.
Kuijpers M, Kochlamazashvili G, Stumpf A, Puchkov D, Swaminathan A, Lucht MT, Krause E, Maritzen T, Schmitz D, Haucke V
Neuron (2021) 1092: 299-313.e9. 124 014 WB; tested species: mouse
Estradiol reverses excitatory synapse loss in a cellular model of neuropsychiatric disorders.
Erli F, Palmos AB, Raval P, Mukherjee J, Sellers KJ, Gatford NJF, Moss SJ, Brandon NJ, Penzes P, Srivastava DP
Translational psychiatry (2020) 101: 16. 124 014 WB, ICC; tested species: rat
Changes in synaptic proteins precede neurodegeneration markers in preclinical Alzheimer's disease cerebrospinal fluid.
Lleó A, Núñez-Llaves R, Alcolea D, Chiva C, Balateu-Paños D, Colom-Cadena M, Gomez-Giro G, Muñoz L, Querol-Vilaseca M, Pegueroles J, Rami L, et al.
Molecular & cellular proteomics : MCP (2019) : . 124 014 WB; tested species: human
Tau is required for the function of extrasynaptic NMDA receptors.
Pallas-Bazarra N, Draffin J, Cuadros R, Antonio Esteban J, Avila J
Scientific reports (2019) 91: 9116. 124 014 WB, IHC; tested species: mouse
The X-Linked Intellectual Disability Gene Zdhhc9 Is Essential for Dendrite Outgrowth and Inhibitory Synapse Formation.
Shimell JJ, Shah BS, Cain SM, Thouta S, Kuhlmann N, Tatarnikov I, Jovellar DB, Brigidi GS, Kass J, Milnerwood AJ, Snutch TP, et al.
Cell reports (2019) 298: 2422-2437.e8. 124 014 WB, ICC; tested species: rat
Piperlongumine decreases cognitive impairment and improves hippocampal function in aged mice.
Go J, Park TS, Han GH, Park HY, Ryu YK, Kim YH, Hwang JH, Choi DH, Noh JR, Hwang DY, Kim S, et al.
International journal of molecular medicine (2018) 424: 1875-1884. 124 014 WB; tested species: mouse
Estradiol reverses excitatory synapse loss in a cellular model of neuropsychiatric disorders.
Erli F, Palmos AB, Raval P, Mukherjee J, Sellers KJ, Gatford NJF, Moss SJ, Brandon NJ, Penzes P, Srivastava DP
Translational psychiatry (2020) 101: 16. 124 014 WB, ICC; tested species: rat
The X-Linked Intellectual Disability Gene Zdhhc9 Is Essential for Dendrite Outgrowth and Inhibitory Synapse Formation.
Shimell JJ, Shah BS, Cain SM, Thouta S, Kuhlmann N, Tatarnikov I, Jovellar DB, Brigidi GS, Kass J, Milnerwood AJ, Snutch TP, et al.
Cell reports (2019) 298: 2422-2437.e8. 124 014 WB, ICC; tested species: rat
Knockout of Amyloid β Protein Precursor (APP) Expression Alters Synaptogenesis, Neurite Branching and Axonal Morphology of Hippocampal Neurons.
Southam KA, Stennard F, Pavez C, Small DH
Neurochemical research (2018) : . 124 014 ICC; tested species: mouse
Variability in the Munc13-1 content of excitatory release sites.
Karlocai MR, Heredi J, Benedek T, Holderith N, Lorincz A, Nusser Z
eLife (2021) 10: . 124 014 IHC, EM; tested species: mouse
A High-Resolution Method for Quantitative Molecular Analysis of Functionally Characterized Individual Synapses.
Holderith N, Heredi J, Kis V, Nusser Z
Cell reports (2020) 324: 107968. 124 014 IHC; tested species: rat
Tau is required for the function of extrasynaptic NMDA receptors.
Pallas-Bazarra N, Draffin J, Cuadros R, Antonio Esteban J, Avila J
Scientific reports (2019) 91: 9116. 124 014 WB, IHC; tested species: mouse
Opposing Roles of apolipoprotein E in aging and neurodegeneration.
Hudry E, Klickstein J, Cannavo C, Jackson R, Muzikansky A, Gandhi S, Urick D, Sargent T, Wrobleski L, Roe AD, Hou SS, et al.
Life science alliance (2019) 21: . 124 014 IHC; tested species: mouse
MicroRNA-mediated disruption of dendritogenesis during a critical period of development influences cognitive capacity later in life.
Lin Q, Ponnusamy R, Widagdo J, Choi JA, Ge W, Probst C, Buckley T, Lou M, Bredy TW, Fanselow MS, Ye K, et al.
Proceedings of the National Academy of Sciences of the United States of America (2017) 11434: 9188-9193. 124 014 IHC; tested species: mouse
Synapse loss in the prefrontal cortex is associated with cognitive decline in amyotrophic lateral sclerosis.
Henstridge CM, Sideris DI, Carroll E, Rotariu S, Salomonsson S, Tzioras M, McKenzie CA, Smith C, von Arnim CAF, Ludolph AC, Lulé D, et al.
Acta neuropathologica (2018) 1352: 213-226. 124 014 IHC-P; tested species: human
Variability in the Munc13-1 content of excitatory release sites.
Karlocai MR, Heredi J, Benedek T, Holderith N, Lorincz A, Nusser Z
eLife (2021) 10: . 124 014 IHC, EM; tested species: mouse
Background

PSD95 (postsynaptic density protein 95 kDa, also called SAP 90: synapse associated protein of 90 kDa and DLG 4) is a component of postsynaptic densities in central synapses. It contains three PDZ domains. The first and second PDZ domain localizes NMDA receptors and K+ channels to synapses, the third binds to neuroligins which are neuronal cell adhesion molecules that interact with β-neurexins and form intercellular junctions. Thus different PDZ domains of PSD 95 might be specialized for distinct functions. Read more: PSD95 single domain antibody