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Homer 1 protein - 160-0P

Homer1 , 2 and 3 are post synaptic density (PSD) proteins involved in the targeting of glutamate receptors
control protein
Cat. No.: 160-0P
Amount: 100 µg
Price: $90.00
Cat. No. 160-0P 100 µg protein, lyophilized. For reconstitution add 100 µl H2O to get a 1mg/ml solution in TBS. Then aliquot and store at -20°C to -80°C until use.
Applications
 
Immunogen Recombinant protein corresponding to the N-terminal half of human Homer 1 (UniProt Id: Q86YM7)
Recommended dilution Optimal concentrations should be determined by the end-user.
Matching antibodies 160 002, 160 003, 160 004, 160 006, 160 011, 160 011BT, 160 008, 160 005, 160 308
Remarks

This control protein consists of the recombinant protein (aa 1 - 186 of human homer) that has been used for immunization. It has been tested in preadsorption experiments and blocks efficiently and specifically the corresponding signal in Western blots. The amount of protein needed for efficient blocking depends on the titer and on the affinity of the antibody to the antigen.

Data sheet 160-0p.pdf
Cat. No.: 160-0P
Amount: 100 µg
Price: $90.00
Background

Homer is a scaffolding protein of the post synaptic density (PSD) and enriched at excitatory synapses. The protein binds metabotropic glutamate receptors, TRPC1, proteins of the Shank family and others. By aggregating these proteins into clusters, homer was suggested to organize distinct signalling domains.
Three isoforms, Homer 1, 2 and 3 have been described. Each of these isoforms is subject to alternative splicing yielding the splice variants a, b, c, d.

Protocols