Acute inflammation in the central nervous system (CNS) is an instant response to the appearance of damaging stimuli and helps to combat infections and promotes tissue repair. Neuroinflammation refers to a chronic inflammation of the CNS which occurs when the host cannot reverse acute infection. Common causes include craniocerebral traumata, spinal cord injuries, viral infections, toxic metabolites, autoimmunity and ageing. Neuroinflammation is caused by resident immune cells and peripheral immune cells that cross the blood-brain barrier and is often associated with an increased blood-brain-barrier (BBB) permeability and breakdown. Neuroinflammation plays a key role in numerous neurodegenerative diseases of both adult and pediatric onset (e.g. Alzheimer’s disease (AD), Parkinson’s disease (PD), Gaucher disease and amyotrophic lateral sclerosis (ALS)).
Learn more: The Brain - The Most Extraordinary Structure In The Universe
A confocal image of a one millimeter thick brain slice stained with the mouse monoclonal Calbindin D28k antibody by Synaptic Systems. In the Brian, Calbindin D28k is particularly concentrated in the dendrites and perikarya of cerebellar Purkinje cells, but is also found in many GABAergic interneurons in the cortex. The image was created by using the Binaree tissue clearing kit.
A confocal image of a one millimeter thick brain slice stained with the mouse monoclonal Parvalbumin antibody by Synaptic Systems. Parvalbumin calcium binding protein specific for a subpopulation of GABAergic interneurones. The image was created by using the Binaree tissue clearing kit.
A confocal image of a one millimeter thick brain slice stained with the GFAP antibody by Synaptic Systems. GFAP is an astrocyte-specific type-III intermediate filament protein and a member of the intermediate filament protein family.
The image was created by using the Binaree tissue clearing kit.
A short video about the new generation of NanoTag's single-domain secondary FluoTags that offers now the possibility to do real muliplexing in immunoflourescent analysis. It is possible to stain one sample with multiple primary antibodies orginating from the same host species, even if they have identical isotypes.
