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c-Fos - 226 003

A member of the transcription factor complex AP1

Polyclonal rabbit purified antibody
370.00 USD
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Cat. No. 226 003 100 µl specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 100 µl H2O. Then aliquot and store at -20°C until use.
Applications WB: 1 : 250 up to 1 : 500 (AP staining) gallery  
IP: not tested yet
ICC: 1 : 1000 gallery  
IHC: 1 : 1000 (see remarks) gallery  
IHC-P/FFPE: not recommended (see remarks)
Immunogen Synthetic peptide corresponding to AA 2 to 17 from rat c-Fos (UniProt Id: P12841)
Reactivity Reacts with: human (P01100), rat (P12841), mouse (P01101), monkey, ape, cow, dog, pig.
Other species not tested yet.
Specificity Specific for c-Fos.
matching control protein/peptide 226-0P

IHC: Signal quality is strongly enhanced when antibody is incubated at RT.

IHC-P: Cat. no. 226 013 is recommended for this application.

Datasheet 226_003.pdf

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References for c-Fos - 226 003

Induced neuronal activity does not attenuate amyloid beta-induced synaptic loss in vitro.
Kono R, Kim GL, Nagata H, Ikegaya Y, Koyama R
Neuropsychopharmacology reports (2019) : . 226 003 ICC; tested species: mouse
Human osteosarcoma cells respond to sorafenib chemotherapy by downregulation of the tumor progression factors S100A4, CXCR4 and the oncogene FOS.
Walter I, Wolfesberger B, Miller I, Mair G, Burger S, Gallè B, Steinborn R
Oncology reports (2014) 313: 1147-56. 226 003 ICC; tested species: human
Photoactivatable Cre recombinase 3.0 for in vivo mouse applications.
Morikawa K, Furuhashi K, de Sena-Tomas C, Garcia-Garcia AL, Bekdash R, Klein AD, Gallerani N, Yamamoto HE, Park SE, Collins GS, Kawano F, et al.
Nature communications (2020) 111: 2141. 226 003 IHC; tested species: mouse
Targeted delivery of engineered auditory sensing protein for ultrasound neuromodulation in the brain.
Wu CY, Fan CH, Chiu NH, Ho YJ, Lin YC, Yeh CK
Theranostics (2020) 108: 3546-3561. 226 003 IHC; tested species: mouse
Encoding of contextual fear memory in hippocampal-amygdala circuit.
Kim WB, Cho JH
Nature communications (2020) 111: 1382. 226 003 IHC; tested species: mouse
Functional hypoxia drives neuroplasticity and neurogenesis via brain erythropoietin.
Wakhloo D, Scharkowski F, Curto Y, Javed Butt U, Bansal V, Steixner-Kumar AA, Wüstefeld L, Rajput A, Arinrad S, Zillmann MR, Seelbach A, et al.
Nature communications (2020) 111: 1313. 226 003 IHC; tested species: mouse
Circulating Triglycerides Gate Dopamine-Associated Behaviors through DRD2-Expressing Neurons.
Berland C, Montalban E, Perrin E, Di Miceli M, Nakamura Y, Martinat M, Sullivan M, Davis XS, Shenasa MA, Martin C, Tolu S, et al.
Cell metabolism (2020) : . 226 003 IHC; tested species: mouse
Multiple inducers and novel roles of autoantibodies against the obligatory NMDAR subunit NR1: a translational study from chronic life stress to brain injury.
Pan H, Steixner-Kumar AA, Seelbach A, Deutsch N, Ronnenberg A, Tapken D, von Ahsen N, Mitjans M, Worthmann H, Trippe R, Klein-Schmidt C, et al.
Molecular psychiatry (2020) : . 226 003 IHC; tested species: mouse
Systemic administration of pentoxifylline attenuates the development of hypertension in renovascular hypertensive rats.
Setiadi A, Korim WS, May CN, Yao ST
Hypertension research : official journal of the Japanese Society of Hypertension (2020) : . 226 003 IHC; tested species: rat
The p75 neurotrophin receptor in AgRP neurons is necessary for homeostatic feeding and food anticipation.
Podyma B, Johnson DA, Sipe L, Remcho TP, Battin K, Liu Y, Yoon SO, Deppmann CD, Güler AD
eLife (2020) 9: . 226 003 IHC; tested species: mouse
The anterior insular cortex unilaterally controls feeding in response to aversive visceral stimuli in mice.
Wu Y, Chen C, Chen M, Qian K, Lv X, Wang H, Jiang L, Yu L, Zhuo M, Qiu S
Nature communications (2020) 111: 640. 226 003 IHC; tested species: mouse
GDF15 Is an Inflammation-Induced Central Mediator of Tissue Tolerance.
Luan H, Wang A, Hilliard B, Carvalho F, Rosen C, Ahasic A, Herzog E, Kang I, Pisani M, Yu S, Zhang C, et al.
Cell (2019) : . 226 003 IHC; tested species: mouse
Activity-dependent reconnection of adult-born dentate granule cells in a mouse model of frontotemporal dementia.
Terreros-Roncal J, Flor-García M, Moreno-Jiménez EP, Pallas-Bazarra N, Rábano A, Sah N, van Praag H, Giacomini D, Schinder AF, Ávila J, Llorens-Martín M, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2019) : . 226 003 IHC; tested species: mouse
Hes1 expression in mature neurons in the adult mouse brain is required for normal behaviors.
Matsuzaki T, Yoshihara T, Ohtsuka T, Kageyama R
Scientific reports (2019) 91: 8251. 226 003 IHC; tested species: mouse
The Systemic Administration of the Chemokine CCL1 Evokes Thermal Analgesia in Mice Through the Activation of the Endocannabinoid System.
García-Domínguez M, Aguirre A, Lastra A, Hidalgo A, Baamonde A, Menéndez L
Cellular and molecular neurobiology (2019) : . 226 003 IHC; tested species: mouse
Regulation of Energy Expenditure by Brainstem GABA Neurons.
Schneeberger M, Parolari L, Das Banerjee T, Bhave V, Wang P, Patel B, Topilko T, Wu Z, Choi CHJ, Yu X, Pellegrino K, et al.
Cell (2019) : . 226 003 IHC; tested species: mouse
Activating an anterior nucleus gigantocellularis subpopulation triggers emergence from pharmacologically-induced coma in rodents.
Gao S, Proekt A, Renier N, Calderon DP, Pfaff DW
Nature communications (2019) 101: 2897. 226 003 IHC; tested species: mouse
Blunted hyperphagic and c-Fos immunoreactivity responsiveness to an orexigen, butorphanol tartrate, in aged rats.
Olszewski PK, McColl LK, Herisson FM, Klockars A, Levine AS
Neuroscience letters (2019) : 134409. 226 003 IHC; tested species: rat
Dopamine Signaling in the Suprachiasmatic Nucleus Enables Weight Gain Associated with Hedonic Feeding.
Grippo RM, Tang Q, Zhang Q, Chadwick SR, Gao Y, Altherr EB, Sipe L, Purohit AM, Purohit NM, Sunkara MD, Cios KJ, et al.
Current biology : CB (2019) : . 226 003 IHC; tested species: mouse
Ultrafast optical clearing method for three-dimensional imaging with cellular resolution.
Zhu X, Huang L, Zheng Y, Song Y, Xu Q, Wang J, Si K, Duan S, Gong W
Proceedings of the National Academy of Sciences of the United States of America (2019) 11623: 11480-11489. 226 003 IHC; tested species: mouse
Neural circuit repair by low-intensity magnetic stimulation requires cellular magnetoreceptors and specific stimulation patterns.
Dufor T, Grehl S, Tang AD, Doulazmi M, Traoré M, Debray N, Dubacq C, Deng ZD, Mariani J, Lohof AM, Sherrard RM, et al.
Science advances (2019) 510: eaav9847. 226 003 IHC; tested species: mouse
Activation of lateral hypothalamic group III metabotropic glutamate receptors suppresses cocaine-seeking following abstinence and normalizes drug-associated increases in excitatory drive to orexin/hypocretin cells.
Yeoh JW, James MH, Adams CD, Bains JS, Sakurai T, Aston-Jones G, Graham BA, Dayas CV
Neuropharmacology (2019) 154: 22-33. 226 003 IHC; tested species: rat
From back to front: A functional model for the cerebellar modulation in the establishment of conditioned preferences for cocaine-related cues.
Gil-Miravet I, Melchor-Eixea I, Arias-Sandoval E, Vasquez-Celaya L, Guarque-Chabrera J, Olucha-Bordonau F, Miquel M
Addiction biology (2019) : e12834. 226 003 IHC; tested species: rat
Uncoupling nNOS-PSD-95 in the ACC can inhibit contextual fear generalization.
Qin C, Bian XL, Cai CY, Chen C, Zhou Y, Lin YH, Tao Y, Wu HY, Chang L, Luo CX, Zhu DY, et al.
Biochemical and biophysical research communications (2019) : . 226 003 IHC; tested species: mouse
Reversible Functional Changes Evoked by Anodal Epidural Direct Current Electrical Stimulation of the Rat Auditory Cortex.
Colmenárez-Raga AC, Díaz I, Pernia M, Pérez-González D, Delgado-García JM, Carro J, Plaza I, Merchán MA
Frontiers in neuroscience (2019) 13: 356. 226 003 IHC; tested species: rat
Active information maintenance in working memory by a sensory cortex.
Zhang X, Yan W, Wang W, Fan H, Hou R, Chen Y, Chen Z, Ge C, Duan S, Compte A, Li CT, et al.
eLife (2019) 8: . 226 003 IHC; tested species: mouse
Artificially Enhancing and Suppressing Hippocampus-Mediated Memories.
Chen BK, Murawski NJ, Cincotta C, McKissick O, Finkelstein A, Hamidi AB, Merfeld E, Doucette E, Grella SL, Shpokayte M, Zaki Y, et al.
Current biology : CB (2019) : . 226 003 IHC; tested species: mouse
Anterior cingulate cortex to ventral hippocampus circuit mediates contextual fear generalization.
Bian XL, Qin C, Cai CY, Zhou Y, Tao Y, Lin YH, Wu HY, Chang L, Luo CX, Zhu DY
The Journal of neuroscience : the official journal of the Society for Neuroscience (2019) : . 226 003 IHC; tested species: mouse
Gamma oscillations in somatosensory cortex recruit prefrontal and descending serotonergic pathways in aversion and nociception.
Tan LL, Oswald MJ, Heinl C, Retana Romero OA, Kaushalya SK, Monyer H, Kuner R
Nature communications (2019) 101: 983. 226 003 IHC; tested species: mouse
Enhanced activity of pyramidal neurons in the infralimbic cortex drives anxiety behavior.
Berg L, Eckardt J, Masseck OA
PloS one (2019) 141: e0210949. 226 003 IHC; tested species: mouse
A novel large animal model of recurrent migraine established by repeated administration of inflammatory soup into the dura mater of the rhesus monkey.
Chen N, Su W, Cui SH, Guo J, Duan JC, Li HX, He L
Neural regeneration research (2019) 141: 100-106. 226 003 IHC; tested species: monkey
Nucleus incertus ablation disrupted conspecific recognition and modified immediate early gene expression patterns in 'social brain' circuits of rats.
García-Díaz C, Sánchez-Catalán MJ, Castro-Salazar E, García-Avilés A, Albert-Gascó H, de la Bárcena SS, Sánchez-Pérez AM, Gundlach AL, Olucha-Bordonau FE
Behavioural brain research (2018) : . 226 003 IHC; tested species: rat
Ventral CA3 Activation Mediates Prophylactic Ketamine Efficacy Against Stress-Induced Depressive-like Behavior.
Mastrodonato A, Martinez R, Pavlova IP, LaGamma CT, Brachman RA, Robison AJ, Denny CA
Biological psychiatry (2018) 8411: 846-856. 226 003 IHC; tested species: mouse
Homeostatic Plasticity in the Hippocampus Facilitates Memory Extinction.
Mendez P, Stefanelli T, Flores CE, Muller D, Lüscher C
Cell reports (2018) 226: 1451-1461. 226 003 IHC; tested species: mouse
Dorsal CA1 interneurons contribute to acute stress-induced spatial memory deficits.
Yu JY, Fang P, Wang C, Wang XX, Li K, Gong Q, Luo BY, Wang XD
Neuropharmacology (2018) : . 226 003 IHC; tested species: mouse
Genetic tagging of active neurons in auditory cortex reveals maternal plasticity of coding ultrasonic vocalizations.
Tasaka GI, Guenthner CJ, Shalev A, Gilday O, Luo L, Mizrahi A
Nature communications (2018) 91: 871. 226 003 IHC; tested species: mouse
Intragastric preloads of l-tryptophan reduce ingestive behavior via oxytocinergic neural mechanisms in male mice.
Gartner SN, Aidney F, Klockars A, Prosser C, Carpenter EA, Isgrove K, Levine AS, Olszewski PK
Appetite (2018) 125: 278-286. 226 003 IHC; tested species: mouse
A GLP-1:CCK fusion peptide harnesses the synergistic effects on metabolism of CCK-1 and GLP-1 receptor agonism in mice.
Hornigold DC, Roth E, Howard V, Will S, Oldham S, Coghlan MP, Blouet C, Trevaskis JL
Appetite (2018) : . 226 003 IHC; tested species: mouse
Astrocytic Activation Generates De Novo Neuronal Potentiation and Memory Enhancement.
Adamsky A, Kol A, Kreisel T, Doron A, Ozeri-Engelhard N, Melcer T, Refaeli R, Horn H, Regev L, Groysman M, London M, et al.
Cell (2018) : . 226 003 IHC; tested species: mouse
Social stress-potentiated methamphetamine seeking.
Blouin AM, Pisupati S, Hoffer CG, Hafenbreidel M, Jamieson SE, Rumbaugh G, Miller CA
Addiction biology (2018) : . 226 003 IHC; tested species: rat
Lipopolysaccharide Challenge Reveals Hypothalamic-Pituitary-Adrenal Axis Dysfunction in Murine Systemic Lupus Erythematosus.
Pham GS, Mathis KW
Brain sciences (2018) 810: . 226 003 IHC; tested species: mouse
Calretinin Neurons in the Midline Thalamus Modulate Starvation-Induced Arousal.
Hua R, Wang X, Chen X, Wang X, Huang P, Li P, Mei W, Li H
Current biology : CB (2018) : . 226 003 IHC; tested species: mouse
Spatial Memory Engram in the Mouse Retrosplenial Cortex.
Milczarek MM, Vann SD, Sengpiel F
Current biology : CB (2018) 2812: 1975-1980.e6. 226 003 IHC; tested species: mouse
Activation of the rat hypothalamic supramammillary nucleus by food anticipation, food restriction or ghrelin administration.
Le May MV, Hume C, Sabatier N, Schéle E, Bake T, Bergström U, Menzies J, Dickson SL
Journal of neuroendocrinology (2018) : e12676. 226 003 IHC; tested species: rat
Excitatory Pathways from the Lateral Habenula Enable Propofol-Induced Sedation.
Gelegen C, Miracca G, Ran MZ, Harding EC, Ye Z, Yu X, Tossell K, Houston CM, Yustos R, Hawkins ED, Vyssotski AL, et al.
Current biology : CB (2018) 284: 580-587.e5. 226 003 IHC; tested species: mouse
Chemogenetic silencing of hippocampal neurons suppresses epileptic neural circuits.
Zhou QG, Nemes AD, Lee D, Ro EJ, Zhang J, Nowacki AS, Dymecki SM, Najm IM, Suh H
The Journal of clinical investigation (2018) : . 226 003 IHC; tested species: mouse
In renovascular hypertension, TNF-α type-1 receptors in the area postrema mediate increases in cardiac and renal sympathetic nerve activity and blood pressure.
Korim WS, Elsaafien K, Basser JR, Setiadi A, May CN, Yao ST
Cardiovascular research (2018) : . 226 003 IHC; tested species: rat
Downregulation of KCNMB4 expression and changes in BK channel subtype in hippocampal granule neurons following seizure activity.
Whitmire LE, Ling L, Bugay V, Carver CM, Timilsina S, Chuang HH, Jaffe DB, Shapiro MS, Cavazos JE, Brenner R
PloS one (2017) 1211: e0188064. 226 003 IHC; tested species: mouse
Plastic embedding immunolabeled large-volume samples for three-dimensional high-resolution imaging.
Gang Y, Liu X, Wang X, Zhang Q, Zhou H, Chen R, Liu L, Jia Y, Yin F, Rao G, Chen J, et al.
Biomedical optics express (2017) 88: 3583-3596. 226 003 IHC; tested species: mouse
A mutant with bilateral whisker to barrel inputs unveils somatosensory mapping rules in the cerebral cortex.
Renier N, Dominici C, Erzurumlu RS, Kratochwil CF, Rijli FM, Gaspar P, Chédotal A
eLife (2017) 6: . 226 003 IHC; tested species: mouse
High-Sugar, but Not High-Fat, Food Activates Supraoptic Nucleus Neurons in the Male Rat.
Hume C, Sabatier N, Menzies J
Endocrinology (2017) 1587: 2200-2211. 226 003 IHC; tested species: rat
mTORC1 in AGRP neurons integrates exteroceptive and interoceptive food-related cues in the modulation of adaptive energy expenditure in mice.
Burke LK, Darwish T, Cavanaugh AR, Virtue S, Roth E, Morro J, Liu SM, Xia J, Dalley JW, Burling K, Chua S, et al.
eLife (2017) 6: . 226 003 IHC; tested species: mouse
Effects of lateral olfactory tract stimulation on Fos immunoreactivity in vasopressin neurones of the rat piriform cortex.
Tsuji C, Tsuji T, Allchorne A, Leng G, Ludwig M
Journal of neuroendocrinology (2017) 2911: . 226 003 IHC; tested species: rat
Cerebellar perineuronal nets in cocaine-induced pavlovian memory: Site matters.
Carbo-Gas M, Moreno-Rius J, Guarque-Chabrera J, Vazquez-Sanroman D, Gil-Miravet I, Carulli D, Hoebeek F, De Zeeuw C, Sanchis-Segura C, Miquel M
Neuropharmacology (2017) 125: 166-180. 226 003 IHC; tested species: mouse
Activation of perineuronal net-expressing excitatory neurons during associative memory encoding and retrieval.
Morikawa S, Ikegaya Y, Narita M, Tamura H
Scientific reports (2017) 7: 46024. 226 003 IHC; tested species: mouse
Detecting and discriminating novel objects: The impact of perirhinal cortex disconnection on hippocampal activity patterns.
Kinnavane L, Amin E, Olarte-Sánchez CM, Aggleton JP
Hippocampus (2016) 2611: 1393-1413. 226 003 IHC
Parallel Arousal Pathways in the Lateral Hypothalamus.
Heiss JE, Yamanaka A, Kilduff TS
eNeuro () 54: . 226 003 IHC; tested species: mouse
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Synaptic Systems GmbH | Rudolf-Wissell-Str. 28 | 37079 Göttingen | Germany
Phone: +49 (0)551/505 56-0 | Internet: | E-Mail: