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GluN2B antibody - 244 115

GluN2A and B are subunits of ionotropic NMDA type glutamate receptors
Guinea pig polyclonal purified antibody
Cat. No.: 244 115
Amount: 50 µg
Price: $460.00
Cat. No. 244 115 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin was added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 1000 (AP staining) gallery  
IP: not tested yet
ICC: not recommended
IHC: not recommended
IHC-P: not tested yet
Immunogen Recombinant protein corresponding to AA 918 to 1470 from rat GluN2B (UniProt Id: Q00960)
Reactivity Reacts with: rat (Q00960), mouse (Q01097).
Other species not tested yet.
Specificity Specific for GluN 2B, no cross-reactivity to GluN 2A.
Data sheet 244_115.pdf

References for GluN2B - 244 115

CDKL5 deficiency in adult glutamatergic neurons alters synaptic activity and causes spontaneous seizures via TrkB signaling.
Zhu ZA, Li YY, Xu J, Xue H, Feng X, Zhu YC, Xiong ZQ
Cell reports (2023) 4210: 113202. 244 115 WB; tested species: mouse
Cat. No.: 244 115
Amount: 50 µg
Price: $460.00
CDKL5 deficiency in adult glutamatergic neurons alters synaptic activity and causes spontaneous seizures via TrkB signaling.
Zhu ZA, Li YY, Xu J, Xue H, Feng X, Zhu YC, Xiong ZQ
Cell reports (2023) 4210: 113202. 244 115 WB; tested species: mouse
Background

GluNs (NMDA-receptors) represent a class of glutamate receptors that are of central importance in synaptic plasticity. Multiple NMDA receptor subtypes exist: GluN1 and GluN2 A-D. GluN1 is the most important as it is required for activity. NMDA-receptors allow Ca2+ influx and are thought to trigger Ca2+ dependent postsynaptic processes involved in long term potentiation and depression.