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GluN 2 A/B antibody - 244 002

GluN2A and B are subunits of ionotropic NMDA type glutamate receptors
Polyclonal rabbit antiserum
Cat. No.: 244 002
Amount: 200 µl
Price: $350.00
Cat. No. 244 002 200 µl antiserum, lyophilized. For reconstitution add 200 µl H2O, then aliquot and store at -20°C until use.
Applications WB: 1 : 1000 (AP staining) gallery  
IP: yes (see remarks)
ICC: not tested yet (see remarks)
IHC: not tested yet
IHC-P/FFPE: not tested yet
Immunogen Synthetic peptide corresponding to AA 1448 to 1464 from mouse GluN2A (UniProt Id: P35436)
Reactivity Reacts with: rat (Q00959, Q00960), mouse (P35436, Q01097).
Other species not tested yet.
Specificity Cross-reacts to GluN 2B due to sequence homology.
Matching control protein/peptide 244-0P
Remarks

IP: For most effective IP use the denaturing SDS based solubilization protocol. Consider that protein-protein interactions may be affected.
ICC: The affinity purified antibody (cat. no. 244 003) is recommended for this application.

Data sheet 244_002.pdf
Cat. No.: 244 002
Quantity: 200 µl
Price: $350.00
Background

GluNs (NMDA-receptors) represent a class of glutamate receptors that are of central importance in synaptic plasticity. Multiple NMDA receptor subtypes exist: GluN 1 and GluN 2 A-D. GluN 1 is the most important as it is required for activity. NMDA-receptors allow Ca2+ influx and are thought to trigger Ca2+ dependent postsynaptic processes involved in long term potentiation and depression.