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GluN 2 A/B antibody - 244 003

GluN2A and B are subunits of ionotropic NMDA type glutamate receptors
Polyclonal rabbit purified antibody
Cat. No.: 244 003
Amount: 50 µg
Price: $450.00
Cat. No. 244 003 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin was added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Applications WB: 1 : 1000 (AP staining) gallery  
IP: yes (see remarks)
ICC: 1 : 250 gallery  
IHC: not tested yet
IHC-P/FFPE: not tested yet
Immunogen Synthetic peptide corresponding to AA 1448 to 1464 from mouse GluN2A (UniProt Id: P35436)
Reactivity Reacts with: rat (Q00959, Q00960), mouse (P35436, Q01097).
Other species not tested yet.
Specificity Cross-reacts to GluN 2B due to sequence homology.
Matching control protein/peptide 244-0P
Remarks

IP: For most effective IP use the denaturing SDS based solubilization protocol. Consider that protein-protein interactions may be affected.

Data sheet 244_003.pdf

References for GluN 2 A/B - 244 003

Novel application of stem cell-derived neurons to evaluate the time- and dose-dependent progression of excitotoxic injury.
Gut IM, Beske PH, Hubbard KS, Lyman ME, Hamilton TA, McNutt PM
PloS one (2013) 85: e64423. 244 003 WB, ICC; tested species: mouse
Novel application of stem cell-derived neurons to evaluate the time- and dose-dependent progression of excitotoxic injury.
Gut IM, Beske PH, Hubbard KS, Lyman ME, Hamilton TA, McNutt PM
PloS one (2013) 85: e64423. 244 003 WB, ICC; tested species: mouse
Cat. No.: 244 003
Quantity: 50 µg
Price: $450.00
Novel application of stem cell-derived neurons to evaluate the time- and dose-dependent progression of excitotoxic injury.
Gut IM, Beske PH, Hubbard KS, Lyman ME, Hamilton TA, McNutt PM
PloS one (2013) 85: e64423. 244 003 WB, ICC; tested species: mouse
Novel application of stem cell-derived neurons to evaluate the time- and dose-dependent progression of excitotoxic injury.
Gut IM, Beske PH, Hubbard KS, Lyman ME, Hamilton TA, McNutt PM
PloS one (2013) 85: e64423. 244 003 WB, ICC; tested species: mouse
Background

GluNs (NMDA-receptors) represent a class of glutamate receptors that are of central importance in synaptic plasticity. Multiple NMDA receptor subtypes exist: GluN 1 and GluN 2 A-D. GluN 1 is the most important as it is required for activity. NMDA-receptors allow Ca2+ influx and are thought to trigger Ca2+ dependent postsynaptic processes involved in long term potentiation and depression.