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SY SY - Synaptic Systems SY SY - Synaptic Systems

Synaptobrevin 2 - 104 202

Major vesicle protein involved in fusion

Polyclonal rabbit antiserum
330.00 USD
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Cat. No. 104 202 200 µl antiserum, lyophilized. For reconstitution add 200 µl H2O, then aliquot and store at -20°C until use.
Applications WB: 1 : 1000 up to 1 : 10000 (AP staining) blot  
IP: yes
ICC: 1 : 500 image  
IHC: 1 : 500 image  
IHC-P/FFPE: 1 : 200 image  
EM: yes
Immunogen Synthetic peptide corresponding to AA 2 to 17 from rat Synaptobrevin2 (UniProt Id: P63045)
Reactivity Reacts with: human (P63027), rat (P63045), mouse (P63044), hamster.
No signal: chicken, zebrafish.
Other species not tested yet.
Specificity Specific for VAMP 2, no cross reactivity to VAMP 1 and VAMP 3.
matching control protein/peptide 104-2P
Remarks This antibody recognizes the Botulinumtoxin B cleavage product (aa 1 - 76) with reduced affinity. The sensitivity is sufficient for the detection of cleaved recombinant protein.For analysis of toxin treated tissue homogenates cat. no. 104 203 is recommended.
Datasheet 104_202.pdf


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References for Synaptobrevin 2 - 104 202

Dopamine Secretion Is Mediated by Sparse Active Zone-like Release Sites.
Liu C, Kershberg L, Wang J, Schneeberger S, Kaeser PS
Cell (2018) 1724: 706-718.e15. 104 202 WB, ICC; tested species: mouse
A novel method for culturing stellate astrocytes reveals spatially distinct Ca2+ signaling and vesicle recycling in astrocytic processes.
Wolfes AC, Ahmed S, Awasthi A, Stahlberg MA, Rajput A, Magruder DS, Bonn S, Dean C
The Journal of general physiology (2017) 1491: 149-170. 104 202 WB
BAIAP3, a C2 domain-containing Munc13 protein, controls the fate of dense-core vesicles in neuroendocrine cells.
Zhang X, Jiang S, Mitok KA, Li L, Attie AD, Martin TFJ
The Journal of cell biology (2017) 2167: 2151-2166. 104 202 WB; tested species: bon cells
Synaptophysin 1 Clears Synaptobrevin 2 from the Presynaptic Active Zone to Prevent Short-Term Depression.
Rajappa R, Gauthier-Kemper A, Böning D, Hüve J, Klingauf J
Cell reports (2016) 146: 1369-1381. 104 202 WB, ICC; tested species: rat
PRRT2 Is a Key Component of the Ca(2+)-Dependent Neurotransmitter Release Machinery.
Valente P, Castroflorio E, Rossi P, Fadda M, Sterlini B, Cervigni RI, Prestigio C, Giovedì S, Onofri F, Mura E, Guarnieri FC, et al.
Cell reports (2016) 151: 117-31. 104 202 WB
Blockade of the SNARE protein syntaxin 1 inhibits glioblastoma tumor growth.
Ulloa F, Gonzàlez-Juncà A, Meffre D, Barrecheguren PJ, Martínez-Mármol R, Pazos I, Olivé N, Cotrufo T, Seoane J, Soriano E
PloS one (2015) 103: e0119707. 104 202 WB
Characterization of VAMP isoforms in 3T3-L1 adipocytes: implications for GLUT4 trafficking.
Sadler JB, Bryant NJ, Gould GW
Molecular biology of the cell (2015) 263: 530-6. 104 202 WB
Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation.
Dettmer U, Newman AJ, Soldner F, Luth ES, Kim NC, von Saucken VE, Sanderson JB, Jaenisch R, Bartels T, Selkoe D
Nature communications (2015) 6: 7314. 104 202 WB; tested species: human
Distribution of SNAP25, VAMP1 and VAMP2 in mature and developing deep cerebellar nuclei after estrogen administration.
Manca P, Mameli O, Caria MA, Torrejón-Escribano B, Blasi J
Neuroscience (2014) 266: 102-15. 104 202 WB, IHC
Synaptic function is modulated by LRRK2 and glutamate release is increased in cortical neurons of G2019S LRRK2 knock-in mice.
Beccano-Kelly DA, Kuhlmann N, Tatarnikov I, Volta M, Munsie LN, Chou P, Cao LP, Han H, Tapia L, Farrer MJ, Milnerwood AJ, et al.
Frontiers in cellular neuroscience (2014) 8: 301. 104 202 WB; tested species: mouse
In vivo cross-linking reveals principally oligomeric forms of α-synuclein and β-synuclein in neurons and non-neural cells.
Dettmer U, Newman AJ, Luth ES, Bartels T, Selkoe D
The Journal of biological chemistry (2013) 2889: 6371-85. 104 202 WB; tested species: rat
Vesicle associated membrane protein (VAMP)-7 and VAMP-8, but not VAMP-2 or VAMP-3, are required for activation-induced degranulation of mature human mast cells.
Sander LE, Frank SP, Bolat S, Blank U, Galli T, Bigalke H, Bischoff SC, Lorentz A
European journal of immunology (2008) 383: 855-63. 104 202 WB; tested species: human,rat
Differential distribution of vesicle associated membrane protein isoforms in the mouse retina.
Sherry DM, Wang MM, Frishman LJ
Molecular vision (2003) 9: 673-88. 104 202 WB, IHC
C-terminal calcium binding of α-synuclein modulates synaptic vesicle interaction.
Lautenschläger J, Stephens AD, Fusco G, Ströhl F, Curry N, Zacharopoulou M, Michel CH, Laine R, Nespovitaya N, Fantham M, Pinotsi D, et al.
Nature communications (2018) 91: 712. 104 202 ICC; tested species: rat
Syntaxins on granules promote docking of granules via interactions with munc18.
Borisovska M
Scientific reports (2018) 81: 193. 104 202 ICC
Dopamine Secretion Is Mediated by Sparse Active Zone-like Release Sites.
Liu C, Kershberg L, Wang J, Schneeberger S, Kaeser PS
Cell (2018) 1724: 706-718.e15. 104 202 WB, ICC; tested species: mouse
The Kohlschütter-Tönz syndrome associated gene Rogdi encodes a novel presynaptic protein.
Riemann D, Wallrafen R, Dresbach T
Scientific reports (2017) 71: 15791. 104 202 ICC; tested species: rat
Botulinum neurotoxin type-A enters a non-recycling pool of synaptic vesicles.
Harper CB, Papadopulos A, Martin S, Matthews DR, Morgan GP, Nguyen TH, Wang T, Nair D, Choquet D, Meunier FA
Scientific reports (2016) 6: 19654. 104 202 ICC
Synaptophysin 1 Clears Synaptobrevin 2 from the Presynaptic Active Zone to Prevent Short-Term Depression.
Rajappa R, Gauthier-Kemper A, Böning D, Hüve J, Klingauf J
Cell reports (2016) 146: 1369-1381. 104 202 WB, ICC; tested species: rat
Phosphorylation of synapsin I by cyclin-dependent kinase-5 sets the ratio between the resting and recycling pools of synaptic vesicles at hippocampal synapses.
Verstegen AM, Tagliatti E, Lignani G, Marte A, Stolero T, Atias M, Corradi A, Valtorta F, Gitler D, Onofri F, Fassio A, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2014) 3421: 7266-80. 104 202 ICC; tested species: mouse
Synapsin selectively controls the mobility of resting pool vesicles at hippocampal terminals.
Orenbuch A, Shalev L, Marra V, Sinai I, Lavy Y, Kahn J, Burden JJ, Staras K, Gitler D
The Journal of neuroscience : the official journal of the Society for Neuroscience (2012) 3212: 3969-80. 104 202 ICC
Structural and functional substrates of tetanus toxin in an animal model of temporal lobe epilepsy.
Ferecskó AS, Jiruska P, Foss L, Powell AD, Chang WC, Sik A, Jefferys JG
Brain structure & function (2015) 2202: 1013-29. 104 202 IHC
Continuous postnatal neurogenesis contributes to formation of the olfactory bulb neural circuits and flexible olfactory associative learning.
Sakamoto M, Ieki N, Miyoshi G, Mochimaru D, Miyachi H, Imura T, Yamaguchi M, Fishell G, Mori K, Kageyama R, Imayoshi I, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2014) 3417: 5788-99. 104 202 IHC; tested species: mouse
Distribution of SNAP25, VAMP1 and VAMP2 in mature and developing deep cerebellar nuclei after estrogen administration.
Manca P, Mameli O, Caria MA, Torrejón-Escribano B, Blasi J
Neuroscience (2014) 266: 102-15. 104 202 WB, IHC
MeCP2 regulates the synaptic expression of a Dysbindin-BLOC-1 network component in mouse brain and human induced pluripotent stem cell-derived neurons.
Larimore J, Ryder PV, Kim KY, Ambrose LA, Chapleau C, Calfa G, Gross C, Bassell GJ, Pozzo-Miller L, Smith Y, Talbot K, et al.
PloS one (2013) 86: e65069. 104 202 IHC; tested species: mouse
Young dentate granule cells mediate pattern separation, whereas old granule cells facilitate pattern completion.
Nakashiba T, Cushman JD, Pelkey KA, Renaudineau S, Buhl DL, McHugh TJ, Rodriguez Barrera V, Chittajallu R, Iwamoto KS, McBain CJ, Fanselow MS, et al.
Cell (2012) 1491: 188-201. 104 202 IHC; tested species: mouse
Differential distribution of vesicle associated membrane protein isoforms in the mouse retina.
Sherry DM, Wang MM, Frishman LJ
Molecular vision (2003) 9: 673-88. 104 202 WB, IHC
A novel flat-embedding method to prepare ultrathin cryosections from cultured cells in their in situ orientation.
Oorschot V, de Wit H, Annaert WG, Klumperman J
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society (2002) 508: 1067-80. 104 202 EM
Synapsin-dependent reserve pool of synaptic vesicles supports replenishment of the readily releasable pool under intense synaptic transmission.
Vasileva M, Horstmann H, Geumann C, Gitler D, Kuner T
The European journal of neuroscience (2012) 368: 3005-20. 104 202 ELISA
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Synaptic Systems GmbH | Rudolf-Wissell-Str. 28 | 37079 Göttingen | Germany
Phone: +49 (0)551/505 56-0 | Internet: http://www.sysy.com | E-Mail: sales@sysy.com