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SY SY - Synaptic Systems SY SY - Synaptic Systems

PSD 95
PDZ domain - 124 014

A component of postsynaptic densities in central synapses

Polyclonal Guinea pig antiserum
350.00 USD
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Cat. No. 124 014 100 µl antiserum, lyophilized. For reconstitution add 100 µl H2O, then aliquot and store at -20°C until use.
Applications WB: 1 : 1000 up to 1 : 10000 (AP staining) gallery  
IP: not tested yet
ICC: 1 : 1000 up to 1 : 3000 (see remarks) gallery  
IHC: not tested yet
IHC-P/FFPE: not tested yet
Immunogen Recombinant protein corresponding to AA 64 to 247 from mouse PSD95 (UniProt Id: Q62108)
Reactivity Reacts with: rat (P31016), mouse (Q62108).
Other species not tested yet.
Specificity Specific for PSD 95 with weak cross-reactivity to SAP 102
matching control protein/peptide 124-01P

ICC: Produces more background staining than the monoclonal antibody cat. no. 124 011.

Datasheet 124_014.pdf

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References for PSD 95
PDZ domain - 124 014

Changes in synaptic proteins precede neurodegeneration markers in preclinical Alzheimer's disease cerebrospinal fluid.
Lleó A, Núñez-Llaves R, Alcolea D, Chiva C, Balateu-Paños D, Colom-Cadena M, Gomez-Giro G, Muñoz L, Querol-Vilaseca M, Pegueroles J, Rami L, et al.
Molecular & cellular proteomics : MCP (2019) : . 124 014 WB; tested species: human
Piperlongumine decreases cognitive impairment and improves hippocampal function in aged mice.
Go J, Park TS, Han GH, Park HY, Ryu YK, Kim YH, Hwang JH, Choi DH, Noh JR, Hwang DY, Kim S, et al.
International journal of molecular medicine (2018) 424: 1875-1884. 124 014 WB; tested species: mouse
Knockout of Amyloid β Protein Precursor (APP) Expression Alters Synaptogenesis, Neurite Branching and Axonal Morphology of Hippocampal Neurons.
Southam KA, Stennard F, Pavez C, Small DH
Neurochemical research (2018) : . 124 014 ICC; tested species: mouse
Opposing Roles of apolipoprotein E in aging and neurodegeneration.
Hudry E, Klickstein J, Cannavo C, Jackson R, Muzikansky A, Gandhi S, Urick D, Sargent T, Wrobleski L, Roe AD, Hou SS, et al.
Life science alliance (2019) 21: . 124 014 IHC; tested species: mouse
MicroRNA-mediated disruption of dendritogenesis during a critical period of development influences cognitive capacity later in life.
Lin Q, Ponnusamy R, Widagdo J, Choi JA, Ge W, Probst C, Buckley T, Lou M, Bredy TW, Fanselow MS, Ye K, et al.
Proceedings of the National Academy of Sciences of the United States of America (2017) 11434: 9188-9193. 124 014 IHC; tested species: mouse
Synapse loss in the prefrontal cortex is associated with cognitive decline in amyotrophic lateral sclerosis.
Henstridge CM, Sideris DI, Carroll E, Rotariu S, Salomonsson S, Tzioras M, McKenzie CA, Smith C, von Arnim CAF, Ludolph AC, Lulé D, et al.
Acta neuropathologica (2018) 1352: 213-226. 124 014 IHC-P; tested species: human
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Synaptic Systems GmbH | Rudolf-Wissell-Str. 28 | 37079 Göttingen | Germany
Phone: +49 (0)551/505 56-0 | Internet: | E-Mail: