Cat. No.: 129 611
Amount: 100 µg
Price:
$415.00
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| Cat. No. 129 611 |
100 µg purified IgG, lyophilized. Azide was added before lyophilization. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications |
IP: yes ICC: not tested yet IHC: not tested yet IHC-P: not tested yet |
| Clone | 91D9 |
| Subtype | IgG1 (κ light chain) |
| Immunogen | Recombinant protein corresponding to AA 42 to 639 from rat Neuroligin1 (UniProt Id: Q62765) |
| Reactivity |
Reacts with: mouse (Q99K10, Q69ZK9, Q8BYM5, B0F2B4), rat (Q62765, Q62888, Q62889, ). Other species not tested yet. |
| Specificity | Recognizes neuroligins 1-4 K.O. validated |
| Remarks |
WB: Shows higher sensitivity compared to 129 011. |
| Data sheet | 129_611.pdf |
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Neuroligins form a family of postsynaptic cell surface molecules that interact with β-neurexins. They are 110-120 kDa polypeptides with homology to acetylcholine esterase. Neuroligin 1 and neuroligin 3 are specifically localized to post-synaptic densities of excitatory synapses whereas neuroligin 2 is found exclusively on inhibitory synapses.
Mutations in neuroligin 3 and neuroligin 4 have been implicated with a rare, heritable form of autism.