Synaptic Systems - Aquaporin4

Cat. No.: 429-0P

Amount: 100 µg

Price: $110.00

Please note that import duties may still apply, which will be billed to you directly by the shipping carrier.

Background

Aquaporin 4 (AQP4) is the most abundant bidirectional water-channel in the central nervous system. It is particularly abundant in astrocytes, where it is highly concentrated in the perivascular end-feet surrounding blood vessels and at the interfaces between brain tissue and cerebrospinal fluid (1). AQP4 is also expressed in ependymal cells and, outside the CNS, in tissues including the kidney, skeletal muscle, lung, stomach and several glandular epithelia (2,3).
It contributes to the regulation of water and ion homeostasis, extracellular volume, brain edema and blood–brain barrier function. AQP4 is also an important component of the glymphatic system, which facilitates the movement and clearance of substances through the brain interstitial space (1,4).
Alterations in AQP4 expression or localization have been implicated in a number of pathological conditions including neuroinflammation, brain edema, traumatic brain injury, neurodegenerative disorders and neuromyelitis optica spectrum disorders (NMOSD)(4).

For more information on protein expression pattern, please refer to the overview image in our SYSY Antibodies ATLAS.

1 ) Nagelhus EA et al., Physiol. Rev. (2013)
2 ) Palazzo C et al., Int J Mol Sci (2020)
3 ) Gleiser C et al., Int J Mol Sci (2016)
4 ) Wang Y et al., Aging Dis (2022)

Other products for this target

Cat. No. 429-0P	100 µg protein, lyophilized. For reconstitution add 100 µl H₂O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Control proteins should be stored at +4°C when still lyophilized. Do not freeze!
Applications
Immunogen	Recombinant protein corresponding to residues near the carboxy terminus of mouse Aquaporin-4 isoform 2 (UniProt Id: P55088-1)
Matching antibodies	429 004, 429 006, 429 011, 429 011BT, 429 008, 429 009
Remarks	This control protein consists of the recombinant protein (aa 249-323 of mouse Aquaporin-4 isoform 2) that has been used for immunization. It has been tested in preadsorption experiments and blocks efficiently and specifically the corresponding signal in Western blots. The amount of protein needed for efficient blocking depends on the titer and on the affinity of the antibody to the antigen.
Data sheet	Data Sheet 429-0p Safety Data Sheet (SDS)

Aquaporin4 protein - 429-0P