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mGluR7 - 191 203

A receptor group for excitatory neurotransmission in the vertebrate nervous system
Polyclonal rabbit purified antibody
Cat. No.: 191 203
Amount: 50 µg
Price: $370.00
Cat. No. 191 203 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Applications WB: 1 : 1000 (AP staining) gallery  
IP: not tested yet
ICC: 1 : 500 gallery  
IHC: not tested yet
IHC-P/FFPE: not tested yet
Immunogen Synthetic peptide corresponding to AA 900 to 922 from human mGluR7 (UniProt Id: Q14831-2)
Reactivity Reacts with: rat, human (Q14831-2), mouse (G5E8D5).
Other species not tested yet.
Specificity Specific for mGluR7b. Does not detect mGluR7a
Data sheet 191_203.pdf
Cat. No.: 191 203
Quantity: 50 µg
Price: $370.00
Background

Glutamate is the main excitatory neurotransmitter in the vertebrate nervous system and regulates a number of cellular signaling pathways. In addition to the ionotropic glutamate receptors of the NMDA, AMPA and kainate type, eight metabotropic receptors (mGluR1 - 8) have been described so far (1). This receptor family can be subdivided into three groups (2): Group I receptors (mGluR1, mGluR5) are activated by dihydroxyphenylglycine (DHPG) (3), group II receptors (mGluR2, mGluR3) by dicarboxycyclopropylglycine (DCG-IV), and group III receptors (mGluR4, mGluR6, mGluR7, mGluR8) by aminophosphonobutyrate (L-AP4) (4).