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mGluR1-alpha antibody - 191 002

mGluRs are metabotropic glutamate receptors involved in excitatory neurotransmission
Rabbit polyclonal antiserum
Cat. No.: 191 002
Amount: 200 µl
Price: $355.00
Cat. No. 191 002 200 µl antiserum, lyophilized. For reconstitution add 200 µl H2O, then aliquot and store at -20°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
WB: 1 : 1000 (AP staining) gallery  
IP: not tested yet
ICC: not recommended
IHC: not recommended
IHC-P: not tested yet
Immunogen Recombinant protein corresponding to residues near the carboxy terminus of mouse mGluR1-α (UniProt Id: P97772)
Reactivity Reacts with: rat (P23385), mouse (P97772).
Other species not tested yet.
Specificity Specific for mGluR1-α
Matching control protein/peptide 191-0P
Data sheet 191_002.pdf
Cat. No.: 191 002
Amount: 200 µl
Price: $355.00

Glutamate is the main excitatory neurotransmitter in the vertebrate nervous system and regulates a number of cellular signaling pathways. In addition to the ionotropic glutamate receptors of the NMDA, AMPA and kainate type, eight metabotropic receptors (mGluR1 - 8) have been described so far (1). This receptor family can be subdivided into three groups (2): Group I receptors (mGluR1, mGluR5) are activated by dihydroxyphenylglycine (DHPG) (3), group II receptors (mGluR2, mGluR3) by dicarboxycyclopropylglycine (DCG-IV), and group III receptors (mGluR4, mGluR6, mGluR7, mGluR8) by aminophosphonobutyrate (L-AP4) (4).