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GluK 1 - 180 313

A ligand-gated ion channel involved in excitatory neurotransmission
Polyclonal rabbit purified antibody
Cat. No.: 180 313
Amount: 50 µg
Price: 370.00 €
Cat. No. 180 313 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C until use.
Applications WB: not tested yet
IP: not tested yet
ICC: not tested yet
IHC: 1 : 5000 up to 1 : 10000 gallery  
IHC-P/FFPE: not tested yet
Immunogen Synthetic peptide corresponding to AA 899 to 918 from human GluK1 (UniProt Id: P39086)
Reactivity Reacts with: mouse (Q60934).
Other species not tested yet.
Specificity Specific for GluK1
Data sheet 180_313.pdf
Cat. No.: 180 313
Quantity: 50 µg
Price: 370.00 €
Background

Ionotropic glutamate receptors (iGluRs) mediate rapid excitatory neurotransmission in the mammalian CNS. They can be subdivided into three major groups, the AMPA/GluA, NMDA/GluN, and kainate/GluK receptors (KARs) (1, 2).
mRNAs coding for glutamate receptors are substrates for an adenosine deaminase acting on RNA (ADAR) that increases the diversity of these proteins (3). KARs can be found at pre- and postsynaptic sites and are composed of five different subunits: GluK1, GluK2 and GluK3 can form homomeric receptors whereas GluK4 and GluK5 form heteromeric receptors with GluK1-3 (4).