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PSD93 antibody - 124 102

PSD93 is a component of postsynaptic densities in central synapses
Rabbit polyclonal antiserum
Cat. No.: 124 102
Amount: 200 µl
Price: $350.00
Cat. No. 124 102 200 µl antiserum, lyophilized. For reconstitution add 200 µl H2O, then aliquot and store at -20°C until use.
Applications
 
WB: 1 : 1000 (AP staining) gallery  
IP: yes , but special protocol (see Valtschanoff et al. 2000)
ICC: not recommended (see remarks)
IHC: not tested yet
IHC-P: not tested yet
Immunogen Synthetic peptide corresponding to AA 22 to 37 from rat PSD93 (UniProt Id: Q63622)
Reactivity Reacts with: human (Q15700), rat (Q63622), mouse (Q91XM9), hamster.
No signal: zebrafish.
Other species not tested yet.
Specificity Specific for PSD 93. K.O.
Matching control protein/peptide 124-1P
Remarks

ICC: The affinity purified antibody (cat. no. 124 103) is recommended.

Data sheet 124_102.pdf

References for PSD93 - 124 102

Altered postsynaptic-density-levels of caldendrin in the para-chloroamphetamine-induced serotonin syndrome but not in the rat ketamine model of psychosis.
Smalla KH, Sahin J, Putzke J, Tischmeyer W, Gundelfinger ED, Kreutz MR
Neurochemical research (2009) 348: 1405-9. 124 102 WB
The molecular chaperone Hsc70 interacts with the vesicular monoamine transporter-2.
Requena DF, Parra LA, Baust TB, Quiroz M, Leak RK, Garcia-Olivares J, Torres GE
Journal of neurochemistry (2009) 1102: 581-94. 124 102 WB
Molecular anatomy of a trafficking organelle.
Takamori S, Holt M, Stenius K, Lemke EA, Grønborg M, Riedel D, Urlaub H, Schenck S, Brügger B, Ringler P, Müller SA, et al.
Cell (2006) 1274: 831-46. 124 102 WB
Immunoisolation of two synaptic vesicle pools from synaptosomes: a proteomics analysis.
Morciano M, Burré J, Corvey C, Karas M, Zimmermann H, Volknandt W
Journal of neurochemistry (2005) 956: 1732-45. 124 102 WB
SAP97 concentrates at the postsynaptic density in cerebral cortex.
Valtschanoff JG, Burette A, Davare MA, Leonard AS, Hell JW, Weinberg RJ
The European journal of neuroscience (2000) 1210: 3605-14. 124 102 WB, IP
SAP97 concentrates at the postsynaptic density in cerebral cortex.
Valtschanoff JG, Burette A, Davare MA, Leonard AS, Hell JW, Weinberg RJ
The European journal of neuroscience (2000) 1210: 3605-14. 124 102 WB, IP
Adult medial habenula neurons require GDNF receptor GFRα1 for synaptic stability and function.
Fernández-Suárez D, Krapacher FA, Pietrajtis K, Andersson A, Kisiswa L, Carrier-Ruiz A, Diana MA, Ibáñez CF
PLoS biology (2021) 1911: e3001350. 124 102 IHC; tested species: mouse
Cat. No.: 124 102
Amount: 200 µl
Price: $350.00
Altered postsynaptic-density-levels of caldendrin in the para-chloroamphetamine-induced serotonin syndrome but not in the rat ketamine model of psychosis.
Smalla KH, Sahin J, Putzke J, Tischmeyer W, Gundelfinger ED, Kreutz MR
Neurochemical research (2009) 348: 1405-9. 124 102 WB
The molecular chaperone Hsc70 interacts with the vesicular monoamine transporter-2.
Requena DF, Parra LA, Baust TB, Quiroz M, Leak RK, Garcia-Olivares J, Torres GE
Journal of neurochemistry (2009) 1102: 581-94. 124 102 WB
Molecular anatomy of a trafficking organelle.
Takamori S, Holt M, Stenius K, Lemke EA, Grønborg M, Riedel D, Urlaub H, Schenck S, Brügger B, Ringler P, Müller SA, et al.
Cell (2006) 1274: 831-46. 124 102 WB
Immunoisolation of two synaptic vesicle pools from synaptosomes: a proteomics analysis.
Morciano M, Burré J, Corvey C, Karas M, Zimmermann H, Volknandt W
Journal of neurochemistry (2005) 956: 1732-45. 124 102 WB
SAP97 concentrates at the postsynaptic density in cerebral cortex.
Valtschanoff JG, Burette A, Davare MA, Leonard AS, Hell JW, Weinberg RJ
The European journal of neuroscience (2000) 1210: 3605-14. 124 102 WB, IP
SAP97 concentrates at the postsynaptic density in cerebral cortex.
Valtschanoff JG, Burette A, Davare MA, Leonard AS, Hell JW, Weinberg RJ
The European journal of neuroscience (2000) 1210: 3605-14. 124 102 WB, IP
Adult medial habenula neurons require GDNF receptor GFRα1 for synaptic stability and function.
Fernández-Suárez D, Krapacher FA, Pietrajtis K, Andersson A, Kisiswa L, Carrier-Ruiz A, Diana MA, Ibáñez CF
PLoS biology (2021) 1911: e3001350. 124 102 IHC; tested species: mouse
Background

PSD93 (postsynaptic density protein of 93 kDa, also called chapsin 110 and DLG 2) belongs to the PSD95 family containing a modular structure with three PDZ-, one SH3- and a guanylate kinase-like domain. It is a component of postsynaptic densities in central synapses.
PSD93 is expressed in discrete neuronal populations as well as in specific non-neuronal cells. It exhibits complex molecular diversity attributable to tissue-specific alternative splicing. PSD93, like PSD95, binds to NMDA receptors and to the neuronal nitric oxide synthase (NOS).
PSD93 and PSD95 can heteromultimerize with each other and are recruited into the same NMDA receptor and K+ channel clusters. PSD93, however, is unique among PSD95 family members in its expression in Purkinje neuron cell bodies and dendrites.