|Cat. No. 124 102||
200 µl antiserum, lyophilized. For reconstitution add 200 µl H2O, then aliquot and store at -20°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Immunoprecipitation (IP); Immunoisolation or pulldown of a target molecule using an antibody. For details and product specific hints, please refer to the ”Remarks” section.', $event)" style="cursor: help;">IP: yes , but special protocol (see Valtschanoff et al. 2000)
Immunocytochemistry (ICC) on 4% PFA fixed cells. Immunoreactivity is usually revealed by fluorescence. Some antibodies require special fixation methods. For details, please refer to the “Remarks” section.', $event)" style="cursor: help;">ICC: not recommended (see remarks)
Immunohistochemistry (IHC) on 4% PFA perfusion fixed tissue with 24h PFA post fixation. Immunoreactivity is usually revealed by fluorescence or a chromogenic substrate. Some antibodies require special fixation methods or antigen retrieval steps. For details, please refer to the ”Remarks” section.', $event)" style="cursor: help;">IHC: not tested yet
Immunohistochemistry (IHC-P) of formalin fixed, paraffin embedded (FFPE) tissue (some antibodies require special antigen retrieval steps, please refer to the ”Remarks” section). Immunoreactivity is usually revealed by fluorescence or a chromogenic substrate.', $event)" style="cursor: help;">IHC-P: not tested yet
|Immunogen||Synthetic peptide corresponding to AA 22 to 37 from rat PSD93 (UniProt Id: Q63622)|
Reacts with: human (Q15700), rat (Q63622), mouse (Q91XM9), hamster.
No signal: zebrafish.
Other species not tested yet.
|Matching control protein/peptide||124-1P|
ICC: The affinity purified antibody (cat. no. 124 103) is recommended.
PSD93 (postsynaptic density protein of 93 kDa, also called chapsin 110 and DLG 2) belongs to the PSD95 family containing a modular structure with three PDZ-, one SH3- and a guanylate kinase-like domain. It is a component of postsynaptic densities in central synapses.
PSD93 is expressed in discrete neuronal populations as well as in specific non-neuronal cells. It exhibits complex molecular diversity attributable to tissue-specific alternative splicing. PSD93, like PSD95, binds to NMDA receptors and to the neuronal nitric oxide synthase (NOS).
PSD93 and PSD95 can heteromultimerize with each other and are recruited into the same NMDA receptor and K+ channel clusters. PSD93, however, is unique among PSD95 family members in its expression in Purkinje neuron cell bodies and dendrites.