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PSD93 antibody - 124 103

PSD93 is a component of postsynaptic densities in central synapses
Rabbit polyclonal purified antibody
Cat. No.: 124 103
Amount: 50 µg
Price: $450.00
Cat. No. 124 103 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin was added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Applications WB: 1 : 1000 (AP staining) gallery  
IP: yes , but special protocol (see Valtschanoff et al. 2000)
ICC: 1 : 100 (see remarks) gallery  
IHC: not tested yet
IHC-P/FFPE: not tested yet
Immunogen Synthetic peptide corresponding to AA 22 to 37 from rat PSD93 (UniProt Id: Q63622)
Reactivity Reacts with: human (Q15700), rat (Q63622), mouse (Q91XM9), hamster.
No signal: zebrafish.
Other species not tested yet.
Specificity Specific for PSD 93. K.O.
Matching control protein/peptide 124-1P
Remarks

ICC: Methanol fixation is recommended.

Data sheet 124_103.pdf
Cat. No.: 124 103
Quantity: 50 µg
Price: $450.00
Background

PSD93 (postsynaptic density protein of 93 kDa, also called chapsin 110 and DLG 2) belongs to the PSD95 family containing a modular structure with three PDZ-, one SH3- and a guanylate kinase-like domain. It is a component of postsynaptic densities in central synapses.
PSD93 is expressed in discrete neuronal populations as well as in specific non-neuronal cells. It exhibits complex molecular diversity attributable to tissue-specific alternative splicing. PSD93, like PSD95, binds to NMDA receptors and to the neuronal nitric oxide synthase (NOS).
PSD93 and PSD95 can heteromultimerize with each other and are recruited into the same NMDA receptor and K+ channel clusters. PSD93, however, is unique among PSD95 family members in its expression in Purkinje neuron cell bodies and dendrites.