|Cat. No. 124-1P||
100 µg peptide, lyophilized. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Control peptides should be stored at -20°C when still lyophilized!
|Immunogen||Synthetic peptide corresponding to AA 22 to 37 from rat PSD93 (UniProt Id: Q63622)|
|Recommended dilution||Optimal concentrations should be determined by the end-user.|
|Matching antibodies||124 102, 124 103|
This control peptide consists of the synthetic peptide (DGPHDHSLPRLTHEVR) that has been used for immunization. It has been tested in preadsorption experiments and blocks efficiently and specifically the corresponding signal in Western blots. The amount of peptide needed for efficient blocking depends on the titer and on the affinity of the antibody to the antigen.
PSD93 (postsynaptic density protein of 93 kDa, also called chapsin 110 and DLG 2) belongs to the PSD95 family containing a modular structure with three PDZ-, one SH3- and a guanylate kinase-like domain. It is a component of postsynaptic densities in central synapses.
PSD93 is expressed in discrete neuronal populations as well as in specific non-neuronal cells. It exhibits complex molecular diversity attributable to tissue-specific alternative splicing. PSD93, like PSD95, binds to NMDA receptors and to the neuronal nitric oxide synthase (NOS).
PSD93 and PSD95 can heteromultimerize with each other and are recruited into the same NMDA receptor and K+ channel clusters. PSD93, however, is unique among PSD95 family members in its expression in Purkinje neuron cell bodies and dendrites.