The Axon Initial Segment (AIS) is a unique compartment at the base of axons. The AIS generates and shapes the action potential before it spreads along the axon. Thus, neuronal excitability depends crucially on the composition and position of the AIS, and these adapt to developmental and physiological conditions. Ankyrin G, also known as ankyrin-3, is a membrane cytoskeletal linker. It may be involved in the targeting and clustering of ion channels and cell adhesion molecules at the nodes of the Ranvier and axonal initial segments (AIS). It is therefore very often used as a marker for AIS.
Synaptic Systems offers a panel of polyclonal and monoclonal antibodies from rabbit, chicken, guinea pig and mouse with superior results in WB, ICC, IHC and IHC-P (FFPE) applications.
We also have antibodies against TRIM46, also known as TRIFIC, in our portfolio. TRIM46 helps to form closely spaced parallel microtubule bundles and is also an excellent marker for AIS.
| Cat. No. | Product Description | Application | Quantity | Price | Cart |
|---|
| 386 003 | Ankyrin G, rabbit, polyclonal, affinity purifiedaffinity | WB ICC IHC IHC-P | 50 µg | $380.00 |   |
| 386 004 | Ankyrin G, Guinea pig, polyclonal, antiserumantiserum K.D. | WB ICC IHC IHC-P | 100 µl | $370.00 | |
| 386 005 | Ankyrin G, Guinea pig, polyclonal, affinity purifiedaffinity | WB IP ICC IHC IHC-P | 50 µg | $465.00 | |
| 386 006 | Ankyrin G, chicken, polyclonal, affinity purifiedaffinity | WB ICC IHC | 50 µg | $380.00 | |
| 386 011 | Ankyrin G, mouse, monoclonal, purified IgG IgG | ICC IHC IHC-P | 100 µg | $415.00 | |
