Cat. No.: 440-0P
Amount: 100 µg
Price:
$105.00
|
|
|
| Cat. No. 440-0P |
100 µg peptide, lyophilized. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Control peptides should be stored at -20°C when still lyophilized! |
| Applications |
|
| Immunogen | Synthetic peptide corresponding to AA 1 to 14 from rat Septin11 (UniProt Id: B3GNI6) |
| Matching antibodies | 440 003 |
| Remarks |
This control peptide consists of the synthetic peptide (aa 1 - 14 of rat Septin 11) that has been used for immunization. It has been tested in preadsorption experiments and blocks efficiently and specifically the corresponding signal in Western blots. The amount of peptide needed for efficient blocking depends on the titer and on the affinity of the antibody to the antigen. |
| Data sheet | 440-0p.pdf |
|
|
Septins are a family of conserved cytoskeletal GTPases implicated in a variety of cellular functions such as cytokinesis and vesicle trafficking. They polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules.
Septin 11 is expressed throughout the brain. Highest levels can be detected in the spiny branchlets of Purkinje cells, in the molecular layer of cerebellum and in the olfactory bulb.
Septin 11 probably plays an important role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines.
A quite high degree of co-localization of Septin 11 with GABAergic synapses suggests its involvement in GABAergic synaptic connectivity.