Cat. No.: 160 011BT
Amount: 100 µg
Price:
$470.00
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| Cat. No. 160 011BT |
100 µg purified IgG, lyophilized, labeled with Biotin.
Biotin is a small vitamin B complex molecule. Its small size minimizes interference with antibody binding sites and allows for efficient conjugation without compromising antibody functionality. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications |
IP: yes ICC: 1 : 100 up to 1 : 500 gallery IHC: not tested yet IHC-P: not tested yet |
| Label | biotin |
| Clone | 2G8 |
| Subtype | IgG1 (κ light chain) |
| Immunogen | Recombinant protein corresponding to the N-terminal half of human Homer 1 (UniProt Id: Q86YM7) |
| Reactivity |
Reacts with: human (Q86YM7), rat (Q9Z214), mouse (Q9Z2Y3). Other species not tested yet. |
| Specificity | Specific for Homer 1. According to Soloviev et al. (2000), aa 1 - 180 are present in isoforms a, b, c and d. |
| Matching control protein/peptide | 160-0P |
| Data sheet | 160_011bt.pdf |
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Homer is a scaffolding protein of the post synaptic density (PSD) and enriched at excitatory synapses. The protein binds metabotropic glutamate receptors, TRPC1, proteins of the Shank family and others. By aggregating these proteins into clusters, homer was suggested to organize distinct signalling domains.
Three isoforms, Homer 1, 2 and 3 have been described. Each of these isoforms is subject to alternative splicing yielding the splice variants a, b, c, d.