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SY SY - Synaptic Systems SY SY - Synaptic Systems

Homer 1 - 160 003

A post synaptic density (PSD) protein involved in the targeting of glutamate receptors

Polyclonal rabbit purified antibody
450.00 USD
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Cat. No. 160 003 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C until use.
Applications WB: 1 : 1000 (AP staining) gallery  
IP: yes
ICC: 1 : 500 up to 1 : 1000 (see remarks) gallery  
IHC: 1 : 200 gallery  
IHC-P/FFPE: 1 : 500 gallery  
ELISA: yes (see remarks)
Immunogen Recombinant protein corresponding to AA 1 to 196 from human Homer1 (UniProt Id: Q86YM7)
Reactivity Reacts with: human (Q86YM7), rat (Q9Z214), mouse (Q9Z2Y3).
Other species not tested yet.
Specificity Specific for Homer 1. Cross-reactivity of the serum to Homer 2 and 3 was removed by pre-adsorption with Homer 2 (aa 1 - 176) and Homer 3 (aa 1 - 177).
matching control protein/peptide 160-0P
Remarks

ICC: PFA fixation recommended.
Methanol fixation leads to a complete loss of the signal.

ELISA: Suitable as detector antibody for sandwich-ELISA with cat. no. 160 011 as capture antibody (protocol for sandwich-ELISA).

Datasheet 160_003.pdf


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References for Homer 1 - 160 003

Neuronal KIF5b deletion induces striatum-dependent locomotor impairments and defects in membrane presentation of dopamine D2 receptors.
Cromberg LE, Saez TMM, Otero MG, Tomasella E, Alloatti M, Damianich A, Devoto VP, Ferrario J, Gelman D, Rubinstein M, Falzone TL, et al.
Journal of neurochemistry (2019) : . 160 003 WB; tested species: human
LRRK2 modifies α-syn pathology and spread in mouse models and human neurons.
Bieri G, Brahic M, Bousset L, Couthouis J, Kramer NJ, Ma R, Nakayama L, Monbureau M, Defensor E, Schüle B, Shamloo M, et al.
Acta neuropathologica (2019) : . 160 003 WB; tested species: mouse
Fluoxetine Suppresses Glutamate- and GABA-Mediated Neurotransmission by Altering SNARE Complex.
Lazarevic V, Mantas I, Flais I, Svenningsson P
International journal of molecular sciences (2019) 2017: . 160 003 WB; tested species: rat
SETD5 Regulates Chromatin Methylation State and Preserves Global Transcriptional Fidelity during Brain Development and Neuronal Wiring.
Sessa A, Fagnocchi L, Mastrototaro G, Massimino L, Zaghi M, Indrigo M, Cattaneo S, Martini D, Gabellini C, Pucci C, Fasciani A, et al.
Neuron (2019) : . 160 003 WB; tested species: mouse
Hippocampal Memory Recovery After Acute Stress: A Behavioral, Morphological and Molecular Study.
Aguayo FI, Tejos-Bravo M, Díaz-Véliz G, Pacheco A, García-Rojo G, Corrales W, Olave FA, Aliaga E, Ulloa JL, Avalos AM, Román-Albasini L, et al.
Frontiers in molecular neuroscience (2018) 11: 283. 160 003 WB; tested species: rat
Homer1a drives homeostatic scaling-down of excitatory synapses during sleep.
Diering GH, Nirujogi RS, Roth RH, Worley PF, Pandey A, Huganir RL
Science (New York, N.Y.) (2017) 3556324: 511-515. 160 003 WB, IP; tested species: mouse
How to Make an Active Zone: Unexpected Universal Functional Redundancy between RIMs and RIM-BPs.
Acuna C, Liu X, Südhof TC
Neuron (2016) 914: 792-807. 160 003 WB
Distinct Defects in Synaptic Differentiation of Neocortical Neurons in Response to Prenatal Valproate Exposure.
Iijima Y, Behr K, Iijima T, Biemans B, Bischofberger J, Scheiffele P
Scientific reports (2016) 6: 27400. 160 003 WB
Homer is concentrated at the postsynaptic density and does not redistribute after acute synaptic stimulation.
Tao-Cheng JH, Thein S, Yang Y, Reese TS, Gallant PE
Neuroscience (2014) 266: 80-90. 160 003 WB, EM; tested species: rat
SAM68 regulates neuronal activity-dependent alternative splicing of neurexin-1.
Iijima T, Wu K, Witte H, Hanno-Iijima Y, Glatter T, Richard S, Scheiffele P
Cell (2011) 1477: 1601-14. 160 003 WB; tested species: mouse
Homer1a drives homeostatic scaling-down of excitatory synapses during sleep.
Diering GH, Nirujogi RS, Roth RH, Worley PF, Pandey A, Huganir RL
Science (New York, N.Y.) (2017) 3556324: 511-515. 160 003 WB, IP; tested species: mouse
Glutaredoxin1 diminishes Aβ mediated oxidation of F-actin and reverses cognitive deficits in an Alzheimer's disease mouse model.
Kommaddi RP, Tomar DS, Karunakaran S, Bapat D, Nanguneri S, Ray A, Schneider BL, Nair D, Ravindranath V
Antioxidants & redox signaling (2019) : . 160 003 ICC; tested species: mouse
A toolbox of nanobodies developed and validated for use as intrabodies and nanoscale immunolabels in mammalian brain neurons.
Dong JX, Lee Y, Kirmiz M, Palacio S, Dumitras C, Moreno CM, Sando R, Santana LF, Südhof TC, Gong B, Murray KD, et al.
eLife (2019) 8: . 160 003 ICC; tested species: mouse
A Method to Visualize the Nanoscopic Morphology of Astrocytes In Vitro and In Situ.
Heller JP, Rusakov DA
Methods in molecular biology (Clifton, N.J.) (2019) 1938: 69-84. 160 003 ICC; tested species: rat
Synaptic neurexin-1 assembles into dynamically regulated active zone nanoclusters.
Trotter JH, Hao J, Maxeiner S, Tsetsenis T, Liu Z, Zhuang X, Südhof TC
The Journal of cell biology (2019) : . 160 003 ICC; tested species: mouse
A practical guide to optimization in X10 expansion microscopy.
Truckenbrodt S, Sommer C, Rizzoli SO, Danzl JG
Nature protocols (2019) : . 160 003 ICC; tested species: rat
Rac1 and Rac3 GTPases differently influence the morphological maturation of dendritic spines in hippocampal neurons.
Pennucci R, Gucciardi I, de Curtis I
PloS one (2019) 148: e0220496. 160 003 ICC; tested species: mouse
Intracellular Zn2+ transients modulate global gene expression in dissociated rat hippocampal neurons.
Sanford L, Carpenter MC, Palmer AE
Scientific reports (2019) 91: 9411. 160 003 ICC; tested species: rat
Aβ mediates F-actin disassembly in dendritic spines leading to cognitive deficits in Alzheimer's disease.
Kommaddi RP, Das D, Karunakaran S, Nanguneri S, Bapat D, Ray A, Shaw E, Bennett DA, Nair D, Ravindranath V
The Journal of neuroscience : the official journal of the Society for Neuroscience (2018) 385: 1085-1099. 160 003 ICC; tested species: mouse
Mapping molecular assemblies with fluorescence microscopy and object-based spatial statistics.
Lagache T, Grassart A, Dallongeville S, Faklaris O, Sauvonnet N, Dufour A, Danglot L, Olivo-Marin JC
Nature communications (2018) 91: 698. 160 003 ICC; tested species: mouse
PICK1 regulates AMPA receptor endocytosis via direct interactions with AP2 α-appendage and dynamin.
Fiuza M, Rostosky CM, Parkinson GT, Bygrave AM, Halemani N, Baptista M, Milosevic I, Hanley JG
The Journal of cell biology (2017) 21610: 3323-3338. 160 003 ICC; tested species: rat
Aberrant neuronal activity-induced signaling and gene expression in a mouse model of RASopathy.
Altmüller F, Pothula S, Annamneedi A, Nakhaei-Rad S, Montenegro-Venegas C, Pina-Fernández E, Marini C, Santos M, Schanze D, Montag D, Ahmadian MR, et al.
PLoS genetics (2017) 133: e1006684. 160 003 ICC
RNA localization is a key determinant of neurite-enriched proteome.
Zappulo A, van den Bruck D, Ciolli Mattioli C, Franke V, Imami K, McShane E, Moreno-Estelles M, Calviello L, Filipchyk A, Peguero-Sanchez E, Müller T, et al.
Nature communications (2017) 81: 583. 160 003 ICC; tested species: mouse
The Cellular and Synaptic Architecture of the Mechanosensory Dorsal Horn.
Abraira VE, Kuehn ED, Chirila AM, Springel MW, Toliver AA, Zimmerman AL, Orefice LL, Boyle KA, Bai L, Song BJ, Bashista KA, et al.
Cell (2017) 1681-2: 295-310.e19. 160 003 ICC; tested species: mouse
Bassoon Controls Presynaptic Autophagy through Atg5.
Okerlund ND, Schneider K, Leal-Ortiz S, Montenegro-Venegas C, Kim SA, Garner LC, Waites CL, Gundelfinger ED, Reimer RJ, Garner CC
Neuron (2017) 934: 897-913.e7. 160 003 ICC; tested species: mouse
Multicolour Multilevel STED nanoscopy of Actin/Spectrin Organization at Synapses.
Sidenstein SC, D'Este E, Böhm MJ, Danzl JG, Belov VN, Hell SW
Scientific reports (2016) 6: 26725. 160 003 ICC
Neuronal activity controls transsynaptic geometry.
Glebov OO, Cox S, Humphreys L, Burrone J
Scientific reports (2016) 6: 22703. 160 003 ICC
Synaptic activity controls localization and function of CtBP1 via binding to Bassoon and Piccolo.
Ivanova D, Dirks A, Montenegro-Venegas C, Schöne C, Altrock WD, Marini C, Frischknecht R, Schanze D, Zenker M, Gundelfinger ED, Fejtova A, et al.
The EMBO journal (2015) 348: 1056-77. 160 003 ICC
Topographic Mapping of the Synaptic Cleft into Adhesive Nanodomains.
Perez de Arce K, Schrod N, Metzbower SWR, Allgeyer E, Kong GK, Tang AH, Krupp AJ, Stein V, Liu X, Bewersdorf J, Blanpied TA, et al.
Neuron (2015) 886: 1165-1172. 160 003 ICC; tested species: rat
STIM2 regulates PKA-dependent phosphorylation and trafficking of AMPARs.
Garcia-Alvarez G, Lu B, Yap KA, Wong LC, Thevathasan JV, Lim L, Ji F, Tan KW, Mancuso JJ, Tang W, Poon SY, et al.
Molecular biology of the cell (2015) 266: 1141-59. 160 003 ICC
High abundance of BDNF within glutamatergic presynapses of cultured hippocampal neurons.
Andreska T, Aufmkolk S, Sauer M, Blum R
Frontiers in cellular neuroscience (2014) 8: 107. 160 003 ICC; tested species: mouse
Effects of erythropoietin in murine-induced pluripotent cell-derived panneural progenitor cells.
Offen N, Flemming J, Kamawal H, Ahmad R, Wolber W, Geis C, Zaehres H, Schöler HR, Ehrenreich H, Müller AM, Sirén AL, et al.
Molecular medicine (Cambridge, Mass.) (2013) 19: 399-408. 160 003 ICC; tested species: mouse
Glucocorticoid-related molecular signaling pathways regulating hippocampal neurogenesis.
Anacker C, Cattaneo A, Luoni A, Musaelyan K, Zunszain PA, Milanesi E, Rybka J, Berry A, Cirulli F, Thuret S, Price J, et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology (2013) 385: 872-83. 160 003 ICC; tested species: human
Activity-dependent regulation of the sumoylation machinery in rat hippocampal neurons.
Loriol C, Khayachi A, Poupon G, Gwizdek C, Martin S
Biology of the cell (2013) 1051: 30-45. 160 003 ICC; tested species: rat
Developmental regulation and spatiotemporal redistribution of the sumoylation machinery in the rat central nervous system.
Loriol C, Parisot J, Poupon G, Gwizdek C, Martin S
PloS one (2012) 73: e33757. 160 003 ICC; tested species: rat
Piccolo regulates the dynamic assembly of presynaptic F-actin.
Waites CL, Leal-Ortiz SA, Andlauer TF, Sigrist SJ, Garner CC
The Journal of neuroscience : the official journal of the Society for Neuroscience (2011) 3140: 14250-63. 160 003 ICC; tested species: mouse
Concerted action of zinc and ProSAP/Shank in synaptogenesis and synapse maturation.
Grabrucker AM, Knight MJ, Proepper C, Bockmann J, Joubert M, Rowan M, Nienhaus GU, Garner CC, Bowie JU, Kreutz MR, Gundelfinger ED, et al.
The EMBO journal (2011) 303: 569-81. 160 003 ICC; tested species: rat
[Artificial urinary sphincter in the treatment of neurogenic bladder in children].
Guys JM, Faure F, Chiapello A, Monfort G
Chirurgie pediatrique (1988) 294: 178-80. 160 003 ICC, IHC; tested species: rat
Combining super-resolution microscopy with neuronal network recording using magnesium fluoride thin films as cover layer for multi-electrode array technology.
Schmidl L, Schmidl G, Gawlik A, Dellith J, Hübner U, Tympel V, Schmidl F, Plentz J, Geis C, Haselmann H
Scientific reports (2019) 91: 16110. 160 003 IHC; tested species: mouse
Structural and functional connections between the median and the ventrolateral preoptic nucleus.
Walter A, van der Spek L, Hardy E, Bemelmans AP, Rouach N, Rancillac A
Brain structure & function (2019) : . 160 003 IHC; tested species: mouse
Region-specific and activity-dependent regulation of SVZ neurogenesis and recovery after stroke.
Liang H, Zhao H, Gleichman A, Machnicki M, Telang S, Tang S, Rshtouni M, Ruddell J, Carmichael ST
Proceedings of the National Academy of Sciences of the United States of America (2019) : . 160 003 IHC; tested species: mouse
Imaging tripartite synapses using super-resolution microscopy.
Heller JP, Odii T, Zheng K, Rusakov DA
Methods (San Diego, Calif.) (2019) : . 160 003 IHC; tested species: mouse
Vaccinia-related kinase 2 plays a critical role in microglia-mediated synapse elimination during neurodevelopment.
Lee J, Lee S, Ryu YJ, Lee D, Kim S, Seo JY, Oh E, Paek SH, Kim SU, Ha CM, Choi SY, et al.
Glia (2019) : . 160 003 IHC; tested species: mouse
Young bone marrow transplantation preserves learning and memory in old mice.
Das MM, Godoy M, Chen S, Moser VA, Avalos P, Roxas KM, Dang I, Yáñez A, Zhang W, Bresee C, Arditi M, et al.
Communications biology (2019) 2: 73. 160 003 IHC; tested species: mouse
Functional Synaptic Architecture of Callosal Inputs in Mouse Primary Visual Cortex.
Lee KS, Vandemark K, Mezey D, Shultz N, Fitzpatrick D
Neuron (2019) 1013: 421-428.e5. 160 003 IHC; tested species: mouse
Enhancing Oligodendrocyte Myelination Rescues Synaptic Loss and Improves Functional Recovery after Chronic Hypoxia.
Wang F, Yang YJ, Yang N, Chen XJ, Huang NX, Zhang J, Wu Y, Liu Z, Gao X, Li T, Pan GQ, et al.
Neuron (2018) 994: 689-701.e5. 160 003 IHC; tested species: mouse
CD47 Protects Synapses from Excess Microglia-Mediated Pruning during Development.
Lehrman EK, Wilton DK, Litvina EY, Welsh CA, Chang ST, Frouin A, Walker AJ, Heller MD, Umemori H, Chen C, Stevens B, et al.
Neuron (2018) 1001: 120-134.e6. 160 003 IHC; tested species: mouse
Restorative effects of human neural stem cell grafts on the primate spinal cord.
Rosenzweig ES, Brock JH, Lu P, Kumamaru H, Salegio EA, Kadoya K, Weber JL, Liang JJ, Moseanko R, Hawbecker S, Huie JR, et al.
Nature medicine (2018) : . 160 003 IHC; tested species: human
The presynaptic ribbon maintains vesicle populations at the hair cell afferent fiber synapse.
Becker L, Schnee ME, Niwa M, Sun W, Maxeiner S, Talaei S, Kachar B, Rutherford MA, Ricci AJ
eLife (2018) 7: . 160 003 IHC
Hallmarks of Alzheimer's Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain.
Espuny-Camacho I, Arranz AM, Fiers M, Snellinx A, Ando K, Munck S, Bonnefont J, Lambot L, Corthout N, Omodho L, Vanden Eynden E, et al.
Neuron (2017) 935: 1066-1081.e8. 160 003 IHC; tested species: human,mouse
Transcriptomic Analysis of Ribosome-Bound mRNA in Cortical Neurites In Vivo.
Ouwenga R, Lake AM, O'Brien D, Mogha A, Dani A, Dougherty JD
The Journal of neuroscience : the official journal of the Society for Neuroscience (2017) 3736: 8688-8705. 160 003 IHC; tested species: mouse
Iterative expansion microscopy.
Chang JB, Chen F, Yoon YG, Jung EE, Babcock H, Kang JS, Asano S, Suk HJ, Pak N, Tillberg PW, Wassie AT, et al.
Nature methods (2017) 146: 593-599. 160 003 IHC; tested species: mouse
Hippocampal Homer1 levels influence motivational behavior in an operant conditioning task.
Wagner KV, Häusl AS, Pöhlmann ML, Hartmann J, Labermaier C, Müller MB, Schmidt MV
PloS one (2014) 91: e85975. 160 003 IHC; tested species: mouse
FMRP regulates multipolar to bipolar transition affecting neuronal migration and cortical circuitry.
La Fata G, Gärtner A, Domínguez-Iturza N, Dresselaers T, Dawitz J, Poorthuis RB, Averna M, Himmelreich U, Meredith RM, Achsel T, Dotti CG, et al.
Nature neuroscience (2014) 1712: 1693-700. 160 003 IHC; tested species: mouse
Homer1 mediates acute stress-induced cognitive deficits in the dorsal hippocampus.
Wagner KV, Hartmann J, Mangold K, Wang XD, Labermaier C, Liebl C, Wolf M, Gassen NC, Holsboer F, Rein T, Müller MB, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2013) 339: 3857-64. 160 003 IHC; tested species: mouse
Superresolution imaging of chemical synapses in the brain.
Dani A, Huang B, Bergan J, Dulac C, Zhuang X
Neuron (2010) 685: 843-56. 160 003 IHC; tested species: mouse
Delayed appearance of the scaffolding proteins PSD-95 and Homer-1 at the developing rat calyx of Held synapse.
Soria Van Hoeve JS, Borst JG
The Journal of comparative neurology (2010) 51822: 4581-90. 160 003 IHC; tested species: rat
[Artificial urinary sphincter in the treatment of neurogenic bladder in children].
Guys JM, Faure F, Chiapello A, Monfort G
Chirurgie pediatrique (1988) 294: 178-80. 160 003 ICC, IHC; tested species: rat
Mitochondrial Ultrastructure Is Coupled to Synaptic Performance at Axonal Release Sites.
Cserép C, Pósfai B, Schwarcz AD, Dénes Á
eNeuro () 51: . 160 003 IHC; tested species: mouse
Synaptic Organization of VGLUT3 Expressing Low-Threshold Mechanosensitive C Fiber Terminals in the Rodent Spinal Cord.
Larsson M, Broman J
eNeuro () 61: . 160 003 IHC; tested species: rat
Homer is concentrated at the postsynaptic density and does not redistribute after acute synaptic stimulation.
Tao-Cheng JH, Thein S, Yang Y, Reese TS, Gallant PE
Neuroscience (2014) 266: 80-90. 160 003 WB, EM; tested species: rat
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Synaptic Systems GmbH | Rudolf-Wissell-Str. 28 | 37079 Göttingen | Germany
Phone: +49 (0)551/505 56-0 | Internet: http://www.sysy.com | E-Mail: sales@sysy.com