Tight junction protein ZO-1 protein - 474-0P

ZO-1 is a scaffold protein involved in tight junction assembly

control protein

Cat. No.: 474-0P

Amount: 100 µg

Price: $110.00

Cat. No. 474-0P	100 µg protein, lyophilized. For reconstitution add 100 µl H₂O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Control proteins should be stored at +4°C when still lyophilized. Do not freeze!
Applications
Immunogen	Recombinant protein corresponding to residues near the carboxy terminus of mouse Tight junction protein ZO-1. (UniProt Id: P39447)
Matching antibodies	474 005
Data sheet	Datasheet 474-0p

Cat. No.: 474-0P

Amount: 100 µg

Price: $110.00

Background

ZO-1 (also known as TJP1) is a peripheral membrane phosphoprotein with a molecular mass of 220 kDa, located on the cytoplasmic face and is expressed in tight junctions of both epithelial and endothelial cells. (1) Two isoforms, ZO-1α− and ZO-1α+, have been described, which, as a result of alternative RNA splicing, differ by an internal 80 amino acid sequence. (2)
ZO-1 binds the transmembrane proteins occludin and the claudins linking them to cytoskeletal actin. (3)

1 ) Stevenson BR et al., J Cell Biol (1986)
2 ) Willott E et al., Am J Physiol (1992)
3 ) Poritz LS et al., J Surg Res (2007)

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