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PSD95 antibody - 124 002

PSD 95 is a component of postsynaptic densities in central synapses
Rabbit polyclonal antiserum
Cat. No.: 124 002
Amount: 200 µl
Price: $350.00
Cat. No. 124 002 200 µl antiserum, lyophilized. For reconstitution add 200 µl H2O, then aliquot and store at -20°C until use.
Applications
 
WB: 1 : 1000 (AP staining) gallery  
IP: yes
ICC: not recommended
IHC: not recommended
IHC-P/FFPE: not tested yet
Immunogen Synthetic peptide corresponding to AA 18 to 32 from rat PSD95 (UniProt Id: P31016)
Reactivity Reacts with: human (P78352), rat (P31016), mouse (Q62108), hamster.
Other species not tested yet.
Specificity Specific for PSD 95.
Matching control protein/peptide 124-0P
Data sheet 124_002.pdf

References for PSD95 - 124 002

Impact of unilateral ureteral obstruction on cognition and neurodegeneration.
Ho YS, Lau CF, Lee K, Tan JY, Lee J, Yung S, Chang RC
Brain research bulletin (2021) 169: 112-127. 124 002 WB; tested species: mouse
The primate-specific peptide Y-P30 regulates morphological maturation of neocortical dendritic spines.
Neumann JR, Dash-Wagh S, Jack A, Räk A, Jüngling K, Hamad MIK, Pape HC, Kreutz MR, Puskarjov M, Wahle P
PloS one (2019) 142: e0211151. 124 002 WB; tested species: rat
Pyk2 Signaling through Graf1 and RhoA GTPase is Required for Amyloid-β Oligomer Triggered Synapse Loss.
Lee S, Salazar SV, Cox TO, Strittmatter SM
The Journal of neuroscience : the official journal of the Society for Neuroscience (2019) : . 124 002 WB; tested species: mouse
The Temporal Dynamics of Arc Expression Regulate Cognitive Flexibility.
Wall MJ, Collins DR, Chery SL, Allen ZD, Pastuzyn ED, George AJ, Nikolova VD, Moy SS, Philpot BD, Shepherd JD, Müller J, et al.
Neuron (2018) : . 124 002 WB; tested species: mouse
Lack of presynaptic interaction between glucocorticoid and CB1 cannabinoid receptors in GABA- and glutamatergic terminals in the frontal cortex of laboratory rodents.
Bitencourt RM, Alpár A, Cinquina V, Ferreira SG, Pinheiro BS, Lemos C, Ledent C, Takahashi RN, Sialana FJ, Lubec G, Cunha RA, et al.
Neurochemistry international (2015) 90: 72-84. 124 002 WB
Human N-methyl D-aspartate receptor antibodies alter memory and behaviour in mice.
Planagumà J, Leypoldt F, Mannara F, Gutiérrez-Cuesta J, Martín-García E, Aguilar E, Titulaer MJ, Petit-Pedrol M, Jain A, Balice-Gordon R, Lakadamyali M, et al.
Brain : a journal of neurology (2015) 138Pt 1: 94-109. 124 002 WB; tested species: mouse
Gender-dependent and genotype-sensitive monoaminergic changes induced by polychlorinated biphenyl 153 in the rat brain.
Dervola KS, Johansen EB, Walaas SI, Fonnum F
Neurotoxicology (2015) 50: 38-45. 124 002 WB
Dysregulated postsynaptic density and endocytic zone in the amygdala of human heroin and cocaine abusers.
Okvist A, Fagergren P, Whittard J, Garcia-Osta A, Drakenberg K, Horvath MC, Schmidt CJ, Keller E, Bannon MJ, Hurd YL
Biological psychiatry (2011) 693: 245-52. 124 002 WB; tested species: human
DHHC5 interacts with PDZ domain 3 of post-synaptic density-95 (PSD-95) protein and plays a role in learning and memory.
Li Y, Hu J, Höfer K, Wong AM, Cooper JD, Birnbaum SG, Hammer RE, Hofmann SL
The Journal of biological chemistry (2010) 28517: 13022-31. 124 002 WB
Altered postsynaptic-density-levels of caldendrin in the para-chloroamphetamine-induced serotonin syndrome but not in the rat ketamine model of psychosis.
Smalla KH, Sahin J, Putzke J, Tischmeyer W, Gundelfinger ED, Kreutz MR
Neurochemical research (2009) 348: 1405-9. 124 002 WB
APP/PS1KI bigenic mice develop early synaptic deficits and hippocampus atrophy.
Breyhan H, Wirths O, Duan K, Marcello A, Rettig J, Bayer TA
Acta neuropathologica (2009) 1176: 677-85. 124 002 WB; tested species: mouse
Astrocytes regulate GluR2 expression in motor neurons and their vulnerability to excitotoxicity.
Van Damme P, Bogaert E, Dewil M, Hersmus N, Kiraly D, Scheveneels W, Bockx I, Braeken D, Verpoorten N, Verhoeven K, Timmerman V, et al.
Proceedings of the National Academy of Sciences of the United States of America (2007) 10437: 14825-30. 124 002 WB
Modulation of NR2B-regulated contextual fear in the hippocampus by the tissue plasminogen activator system.
Norris EH, Strickland S
Proceedings of the National Academy of Sciences of the United States of America (2007) 10433: 13473-8. 124 002 WB
Molecular anatomy of a trafficking organelle.
Takamori S, Holt M, Stenius K, Lemke EA, Grønborg M, Riedel D, Urlaub H, Schenck S, Brügger B, Ringler P, Müller SA, et al.
Cell (2006) 1274: 831-46. 124 002 WB
Immunoisolation of two synaptic vesicle pools from synaptosomes: a proteomics analysis.
Morciano M, Burré J, Corvey C, Karas M, Zimmermann H, Volknandt W
Journal of neurochemistry (2005) 956: 1732-45. 124 002 WB; tested species: rat
Differential recruitment of Kv1.4 and Kv4.2 to lipid rafts by PSD-95.
Wong W, Schlichter LC
The Journal of biological chemistry (2004) 2791: 444-52. 124 002 WB
Distribution of synaptic vesicle proteins in the mammalian retina identifies obligatory and facultative components of ribbon synapses.
Von Kriegstein K, Schmitz F, Link E, Südhof TC
The European journal of neuroscience (1999) 114: 1335-48. 124 002 WB
Live Neuron High-Content Screening Reveals Synaptotoxic Activity in Alzheimer Mouse Model Homogenates.
Jiang H, Esparza TJ, Kummer TT, Zhong H, Rettig J, Brody DL
Scientific reports (2020) 101: 3412. 124 002 ICC; tested species: mouse
Cat. No.: 124 002
Amount: 200 µl
Price: $350.00
Impact of unilateral ureteral obstruction on cognition and neurodegeneration.
Ho YS, Lau CF, Lee K, Tan JY, Lee J, Yung S, Chang RC
Brain research bulletin (2021) 169: 112-127. 124 002 WB; tested species: mouse
The primate-specific peptide Y-P30 regulates morphological maturation of neocortical dendritic spines.
Neumann JR, Dash-Wagh S, Jack A, Räk A, Jüngling K, Hamad MIK, Pape HC, Kreutz MR, Puskarjov M, Wahle P
PloS one (2019) 142: e0211151. 124 002 WB; tested species: rat
Pyk2 Signaling through Graf1 and RhoA GTPase is Required for Amyloid-β Oligomer Triggered Synapse Loss.
Lee S, Salazar SV, Cox TO, Strittmatter SM
The Journal of neuroscience : the official journal of the Society for Neuroscience (2019) : . 124 002 WB; tested species: mouse
The Temporal Dynamics of Arc Expression Regulate Cognitive Flexibility.
Wall MJ, Collins DR, Chery SL, Allen ZD, Pastuzyn ED, George AJ, Nikolova VD, Moy SS, Philpot BD, Shepherd JD, Müller J, et al.
Neuron (2018) : . 124 002 WB; tested species: mouse
Lack of presynaptic interaction between glucocorticoid and CB1 cannabinoid receptors in GABA- and glutamatergic terminals in the frontal cortex of laboratory rodents.
Bitencourt RM, Alpár A, Cinquina V, Ferreira SG, Pinheiro BS, Lemos C, Ledent C, Takahashi RN, Sialana FJ, Lubec G, Cunha RA, et al.
Neurochemistry international (2015) 90: 72-84. 124 002 WB
Human N-methyl D-aspartate receptor antibodies alter memory and behaviour in mice.
Planagumà J, Leypoldt F, Mannara F, Gutiérrez-Cuesta J, Martín-García E, Aguilar E, Titulaer MJ, Petit-Pedrol M, Jain A, Balice-Gordon R, Lakadamyali M, et al.
Brain : a journal of neurology (2015) 138Pt 1: 94-109. 124 002 WB; tested species: mouse
Gender-dependent and genotype-sensitive monoaminergic changes induced by polychlorinated biphenyl 153 in the rat brain.
Dervola KS, Johansen EB, Walaas SI, Fonnum F
Neurotoxicology (2015) 50: 38-45. 124 002 WB
Dysregulated postsynaptic density and endocytic zone in the amygdala of human heroin and cocaine abusers.
Okvist A, Fagergren P, Whittard J, Garcia-Osta A, Drakenberg K, Horvath MC, Schmidt CJ, Keller E, Bannon MJ, Hurd YL
Biological psychiatry (2011) 693: 245-52. 124 002 WB; tested species: human
DHHC5 interacts with PDZ domain 3 of post-synaptic density-95 (PSD-95) protein and plays a role in learning and memory.
Li Y, Hu J, Höfer K, Wong AM, Cooper JD, Birnbaum SG, Hammer RE, Hofmann SL
The Journal of biological chemistry (2010) 28517: 13022-31. 124 002 WB
Altered postsynaptic-density-levels of caldendrin in the para-chloroamphetamine-induced serotonin syndrome but not in the rat ketamine model of psychosis.
Smalla KH, Sahin J, Putzke J, Tischmeyer W, Gundelfinger ED, Kreutz MR
Neurochemical research (2009) 348: 1405-9. 124 002 WB
APP/PS1KI bigenic mice develop early synaptic deficits and hippocampus atrophy.
Breyhan H, Wirths O, Duan K, Marcello A, Rettig J, Bayer TA
Acta neuropathologica (2009) 1176: 677-85. 124 002 WB; tested species: mouse
Astrocytes regulate GluR2 expression in motor neurons and their vulnerability to excitotoxicity.
Van Damme P, Bogaert E, Dewil M, Hersmus N, Kiraly D, Scheveneels W, Bockx I, Braeken D, Verpoorten N, Verhoeven K, Timmerman V, et al.
Proceedings of the National Academy of Sciences of the United States of America (2007) 10437: 14825-30. 124 002 WB
Modulation of NR2B-regulated contextual fear in the hippocampus by the tissue plasminogen activator system.
Norris EH, Strickland S
Proceedings of the National Academy of Sciences of the United States of America (2007) 10433: 13473-8. 124 002 WB
Molecular anatomy of a trafficking organelle.
Takamori S, Holt M, Stenius K, Lemke EA, Grønborg M, Riedel D, Urlaub H, Schenck S, Brügger B, Ringler P, Müller SA, et al.
Cell (2006) 1274: 831-46. 124 002 WB
Immunoisolation of two synaptic vesicle pools from synaptosomes: a proteomics analysis.
Morciano M, Burré J, Corvey C, Karas M, Zimmermann H, Volknandt W
Journal of neurochemistry (2005) 956: 1732-45. 124 002 WB; tested species: rat
Differential recruitment of Kv1.4 and Kv4.2 to lipid rafts by PSD-95.
Wong W, Schlichter LC
The Journal of biological chemistry (2004) 2791: 444-52. 124 002 WB
Distribution of synaptic vesicle proteins in the mammalian retina identifies obligatory and facultative components of ribbon synapses.
Von Kriegstein K, Schmitz F, Link E, Südhof TC
The European journal of neuroscience (1999) 114: 1335-48. 124 002 WB
Live Neuron High-Content Screening Reveals Synaptotoxic Activity in Alzheimer Mouse Model Homogenates.
Jiang H, Esparza TJ, Kummer TT, Zhong H, Rettig J, Brody DL
Scientific reports (2020) 101: 3412. 124 002 ICC; tested species: mouse
Background

PSD95 (postsynaptic density protein 95 kDa, also called SAP 90: synapse associated protein of 90 kDa and DLG 4) is a component of postsynaptic densities in central synapses. It contains three PDZ domains. The first and second PDZ domain localizes NMDA receptors and K+ channels to synapses, the third binds to neuroligins which are neuronal cell adhesion molecules that interact with β-neurexins and form intercellular junctions. Thus different PDZ domains of PSD 95 might be specialized for distinct functions. Read more: PSD95 single domain antibody