|Cat. No. 110 011C3||
100 µg purified IgG, lyophilized, fluorescence-labeled with Oyster® 550
Fluorescence labeled antibodies conjugated to Oyster dyes from
Oyster dyes, Oyster-488, Oyster-500, Oyster-550, and Oyster-650 are trademarks of Luminartis GmbH, Muenster/Germany.
CyDyes, Cy2, Cy3, and Cy5 are trademarks of GE-Healthcare Ltd.
Reconstitute immediately upon receipt! Avoid bright light when working with the antibody to minimize photo bleeching of the fluorescent dye.The mounting agent Aquatex®(Merck Chemicals) is not compatible with Oyster dyes!
ICC: 1 : 200 up to 1 : 1000 gallery
IHC: 1 : 200
IHC-P/FFPE: not tested yet
|Subtype||IgG1 (κ light chain)|
|Immunogen||Recombinant protein corresponding to AA 1 to 262 from rat Syntaxin1A (UniProt Id: P32851)|
Reacts with: human (Q16623, P61266), rat (P32851, P61265), mouse (O35526, P61264), mammals, chicken, zebrafish, leech.
Other species not tested yet.
|Specificity||Syntaxin 1A and B with preference for syntaxin 1B.|
|Matching control protein/peptide||110-1P|
Syntaxin 1, also known as p35, is a small integral membrane protein that is abundantly expressed in neurons and neuroendocrine cells. It was initially discovered as HPC-1. Syntaxin 1 is an essential component of the exocytotic fusion machine and interacts with several other proteins important for synaptic function, including its partners in the fusion complex synaptobrevin, SNAP 25, α-SNAP, synaptotagmin 1, Munc 18/n-Sec1 and Ca2+-channels.
Syntaxin 1 is localized primarily to the neuronal plasmalemma and is concentrated in synapses where pools of the protein are also present on recycling organelles including synaptic vesicles. It is the main target of one of the Botulinum neurotoxins BoNT/C1 which, however, cannot cleave the protein when complexed with its partner proteins in the fusion complex.