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ZnT3 antibody - 197 003DY5

ZnT3 is a synaptic vesicle located zinc-transporter
Rabbit polyclonal purified antibody
Cat. No.: 197 003DY5
Amount: 50 µg
Price: $480.00
Cat. No. 197 003DY5 50 µg specific antibody, lyophilized. Affinity purified with the immunogen, fluorescence-labeled with DY 649P.

For fluorescence labeled antibodies and other products conjugated to Dyomics® dyes from Dyomics GmbH the established established fluorescence detection systems can be used.

DY-488: λex 493 nm / λem 518 nm
DY-654: λex 653 nm / λem 677 nm
DY-649P: λex 654 nm / λem 672 nm

This product or portions thereof is manufactured under license from Dyomics GmbH. 
Dyomics is a trademarks of Dyomics GmbH, Jena/Germany.
Purchase of reagents related to the Dyomics technology from Synaptic Systems GmbH provides a license for non-profit and in-house research use only. Any application of above mentioned technology for commercial purpose requires a separate license from Dyomics.

Albumin was added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Either add 1:1 (v/v) glycerol, then aliquot and store at -20°C until use, or store aliquots at -80°C without additives.
Reconstitute immediately upon receipt! Avoid bright light when working with the antibody to minimize photo bleeching of the fluorescent dye.
Applications
 
WB: N/A
IP: N/A
ICC: 1 : 500 gallery  
IHC: 1 : 500 gallery  
IHC-P: not tested yet
Label DY 649P
Immunogen Recombinant protein corresponding to AA 2 to 75 from mouse ZnT3 (UniProt Id: P97441)
Reactivity Reacts with: human (Q99726), rat (Q6QIX3), mouse (P97441).
No signal: zebrafish.
Other species not tested yet.
Matching control protein/peptide 197-0P
Data sheet 197_003dy5.pdf
Cat. No.: 197 003DY5
Amount: 50 µg
Price: $480.00
Background

The essential micronutrient zinc plays an important role in many biological processes like growth, development and reproduction. It is found in the active site of many enzymes, where ionization, polarization or replacement of Zn2+ bound water is involved in catalytic reactions. As a charged ion Zn2+ cannot cross biological membranes by simple diffusion and must be transported into or out of cells by specialized transport mechanisms. Four Zn transporter proteins, ZnT 1 to ZnT 4, have been cloned. All of them contain several transmembrane domains and a histidine rich intracellular loop.
In the central nervous system Zn plays important roles in synaptic function and plasticity. At synapses Zn is stored in synaptic vesicles by a mechanism depending on the integral membrane protein ZnT 3.