Cat. No.: 197 003DY2
Amount: 50 µg
Price:
$480.00
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| Cat. No. 197 003DY2 |
50 µg specific antibody, lyophilized. Affinity purified with the immunogen, fluorescence-labeled with DY 488.
For fluorescence labeled antibodies and other products conjugated to Dyomics® dyes from Dyomics GmbH the established established fluorescence detection systems can be used.
This product or portions thereof is manufactured under license from Dyomics GmbH. Reconstitute immediately upon receipt! Avoid bright light when working with the antibody to minimize photo bleeching of the fluorescent dye. |
| Applications | |
| Label | DY 488 |
| Immunogen | Recombinant protein corresponding to AA 2 to 75 from mouse ZnT3 (UniProt Id: P97441) |
| Reactivity |
Reacts with: human (Q99726), rat (Q6QIX3), mouse (P97441). No signal: zebrafish. Other species not tested yet. |
| Matching control protein/peptide | 197-0P |
| Data sheet | 197_003dy2.pdf |
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The essential micronutrient zinc plays an important role in many biological processes like growth, development and reproduction. It is found in the active site of many enzymes, where ionization, polarization or replacement of Zn2+ bound water is involved in catalytic reactions. As a charged ion Zn2+ cannot cross biological membranes by simple diffusion and must be transported into or out of cells by specialized transport mechanisms. Four Zn transporter proteins, ZnT 1 to ZnT 4, have been cloned. All of them contain several transmembrane domains and a histidine rich intracellular loop.
In the central nervous system Zn plays important roles in synaptic function and plasticity. At synapses Zn is stored in synaptic vesicles by a mechanism depending on the integral membrane protein ZnT 3.