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Home > Products > 138 313

VMaT2 antibody - 138 313

VMaT2 is a monoamine transporter in the membrane of small synaptic vesicles
Rabbit polyclonal purified antibody
Cat. No.: 138 313
Amount: 50 µg
Price: $375.00
Cat. No. 138 313 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: not tested yet
IP: not tested yet
ICC: not tested yet
IHC: 1 : 200 up to 1 : 500 gallery  
IHC-P: not tested yet
Immunogen Synthetic peptide corresponding to AA 1 to 20 from mouse VMaT2 (UniProt Id: Q8BRU6)
Reactivity Reacts with: rat (Q8BRU6), mouse (Q8BRU6).
Other species not tested yet.
Data sheet 138_313.pdf

References for VMaT2 - 138 313

Vortioxetine attenuates the effects of early-life stress on depression-like behaviors and monoamine transporters in female mice.
Liu X, Sun YX, Zhang CC, Zhang XQ, Zhang Y, Wang T, Ma YN, Wang H, Su YA, Li JT, Si TM, et al.
Neuropharmacology (2021) : 108468. 138 313 IHC; tested species: mouse
Innervation and Neuronal Control of the Mammalian Sinoatrial Node a Comprehensive Atlas.
Hanna P, Dacey MJ, Brennan J, Moss A, Robbins S, Achanta S, Biscola NP, Swid MA, Rajendran PS, Mori S, Hadaya JE, et al.
Circulation research (2021) 1289: 1279-1296. 138 313 IHC; tested species: pig
Cell Types Promoting Goosebumps Form a Niche to Regulate Hair Follicle Stem Cells.
Shwartz Y, Gonzalez-Celeiro M, Chen CL, Pasolli HA, Sheu SH, Fan SM, Shamsi F, Assaad S, Lin ET, Zhang B, Tsai PC, et al.
Cell (2020) : . 138 313 IHC; tested species: mouse
Immunohistochemical analysis of the mouse celiac ganglion: An integrative relay station of the peripheral nervous system.
Kaestner CL, Smith EH, Peirce SG, Hoover DB
The Journal of comparative neurology (2019) : . 138 313 IHC; tested species: mouse
Colocalization of different neurotransmitter transporters on synaptic vesicles is sparse except for VGLUT1 and ZnT3.
Upmanyu N, Jin J, Emde HV, Ganzella M, Bösche L, Malviya VN, Zhuleku E, Politi AZ, Ninov M, Silbern I, Leutenegger M, et al.
Neuron (2022) : . 138 313 UPTAKE; tested species: rat
Cat. No.: 138 313
Amount: 50 µg
Price: $375.00
Vortioxetine attenuates the effects of early-life stress on depression-like behaviors and monoamine transporters in female mice.
Liu X, Sun YX, Zhang CC, Zhang XQ, Zhang Y, Wang T, Ma YN, Wang H, Su YA, Li JT, Si TM, et al.
Neuropharmacology (2021) : 108468. 138 313 IHC; tested species: mouse
Innervation and Neuronal Control of the Mammalian Sinoatrial Node a Comprehensive Atlas.
Hanna P, Dacey MJ, Brennan J, Moss A, Robbins S, Achanta S, Biscola NP, Swid MA, Rajendran PS, Mori S, Hadaya JE, et al.
Circulation research (2021) 1289: 1279-1296. 138 313 IHC; tested species: pig
Cell Types Promoting Goosebumps Form a Niche to Regulate Hair Follicle Stem Cells.
Shwartz Y, Gonzalez-Celeiro M, Chen CL, Pasolli HA, Sheu SH, Fan SM, Shamsi F, Assaad S, Lin ET, Zhang B, Tsai PC, et al.
Cell (2020) : . 138 313 IHC; tested species: mouse
Immunohistochemical analysis of the mouse celiac ganglion: An integrative relay station of the peripheral nervous system.
Kaestner CL, Smith EH, Peirce SG, Hoover DB
The Journal of comparative neurology (2019) : . 138 313 IHC; tested species: mouse
Colocalization of different neurotransmitter transporters on synaptic vesicles is sparse except for VGLUT1 and ZnT3.
Upmanyu N, Jin J, Emde HV, Ganzella M, Bösche L, Malviya VN, Zhuleku E, Politi AZ, Ninov M, Silbern I, Leutenegger M, et al.
Neuron (2022) : . 138 313 UPTAKE; tested species: rat
IHC
Background
Vesicular monoamine transporters VMaTs mediate the translocation of monoamines (serotonin, histamine, dopamine) from the cytoplasm into secretory vesicles by using a proton electrochemical gradient.
VMaTs are integral membrane proteins with 12 putative trans-membrane domains predicted by sequence analysis. Both, the N- and C-terminus of the proteins are located on the cytoplasmic side.
Two VMaT isoforms, VMaT 1 and VMaT 2, have been described. It has been proposed that VMaT 1 transports monoamines into large dense core vesicles (LDCVs), whereas VMaT 2 is needed for the loading of small synaptic vesicles (SSVs).
In rat VMaT 1 is expressed in the adrenal gland, while VMaT 2 is expressed in brain.
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