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Tyrosine hydroxylase antibody - 213 111

Tyrosine hydroxylase is the rate limiting enzyme in catecholamine synthesis
Mouse monoclonal purified IgG
Cat. No.: 213 111
Amount: 100 µg
Price: $415.00
Cat. No. 213 111 100 µg purified IgG, lyophilized. Azide was added before lyophilization. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 500 up to 1 : 1000 (AP staining) (see remarks) gallery  
IP: yes
ICC: 1 : 500 gallery  
IHC: 1 : 100 up to 1 : 500 gallery  
IHC-P: 1 : 500 up to 1 : 1000 gallery  
Clone 43F2
Subtype IgG2b (κ light chain)
Immunogen Recombinant protein corresponding to residues near the amino-terminus of rat TyrH. (UniProt Id: P04177)
Epitop Epitop: AA 65 to 163 from rat TyrH (UniProt Id: P04177)
Reactivity Reacts with: rat (P04177), mouse (P24529).
Other species not tested yet.
Remarks

WB: This antibody is less sensitive than the polyclonal antibodies (cat. no. 213 102 and 213 104.

Data sheet 213_111.pdf

References for Tyrosine hydroxylase - 213 111

Auxiliary α2δ1 and α2δ3 Subunits of Calcium Channels Drive Excitatory and Inhibitory Neuronal Network Development.
Bikbaev A, Ciuraszkiewicz-Wojciech A, Heck J, Klatt O, Freund R, Mitlöhner J, Enrile Lacalle S, Sun M, Repetto D, Frischknecht R, Ablinger C, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2020) 4025: 4824-4841. 213 111 WB; tested species: mouse
Cat. No.: 213 111
Amount: 100 µg
Price: $415.00
Auxiliary α2δ1 and α2δ3 Subunits of Calcium Channels Drive Excitatory and Inhibitory Neuronal Network Development.
Bikbaev A, Ciuraszkiewicz-Wojciech A, Heck J, Klatt O, Freund R, Mitlöhner J, Enrile Lacalle S, Sun M, Repetto D, Frischknecht R, Ablinger C, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2020) 4025: 4824-4841. 213 111 WB; tested species: mouse
Background
Tyrosine hydroxylase is one of the key enzymes in the synthesis pathway of catecholamines like adrenalin, noradrenalin and dopamin and is frequently used as a marker for dopaminergic neurons. This neuronal subpopulation is especially affected in Parkinson's disease.