Cat. No.: 302 304
Amount: 100 µl
Price:
$370.00
|
|
|
| Cat. No. 302 304 |
100 µl antiserum, lyophilized. For reconstitution add 100 µl H2O, then aliquot and store at -20°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications | |
| Immunogen | Synthetic peptide corresponding to residues near the carboxy terminus of mouse β3-tubulin (UniProt Id: Q9ERD7) |
| Reactivity |
Reacts with: human (Q13509), rat (Q4QRB4), mouse (Q9ERD7). Other species not tested yet. |
| Specificity | Specific for β3-tubulin. |
| Matching control protein/peptide | 302-3P |
| Remarks |
IHC: For best results we recommend antigen retrieval with pepsin according to Lorincz A & Nusser Z (2008). |
| Data sheet | 302_304.pdf |
|
|
Microtubules are involved in a wide variety of cellular activities ranging from mitosis and transport events to cell movement and the maintainance of cell shape (1).
Tubulin itself is a globular protein which consists of two polypeptides, α-tubulin and β-tubulin. α- and β-tubulin dimers are assembled to 13 protofilaments that form a microtubule of 25 nm diameter (1).
Class III β-tubulin is abundant in the central and peripheral nervous systems (CNS and PNS) where it is prominently expressed during fetal and postnatal development (2).
It is widely used as a neuronal marker in normal and neoplastic tissues but has also been reported to be expressed in certain tumours of non-neuronal origin (3).