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Home > Products > 377 003

TRIM46 antibody - 377 003

TRIM46 is involved in establishing neuronal polarity
Rabbit polyclonal purified antibody
Cat. No.: 377 003
Amount: 50 µg
Price: $375.00
Cat. No. 377 003 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: not tested yet
IP: not tested yet
ICC: 1 : 500 gallery  
IHC: 1 : 500 (see remarks) gallery  
IHC-P: 1 : 500 gallery  
Immunogen Recombinant protein corresponding to AA 1 to 561 from rat Trim46 (UniProt Id: A0A0G2JXN2)
Reactivity Reacts with: rat (A0A0G2JXN2), mouse (Q7TNM2).
Other species not tested yet.
Remarks

IHC: For optimal signal to noise ratio, we recommend our recombinant rabbit TRIM46 antibody 377 008
Data sheet 377_003.pdf

References for TRIM46 - 377 003

Efficient axonal transport of endolysosomes relies on the balanced ratio of microtubule tyrosination and detyrosination.
Konietzny A, Han Y, Popp Y, van Bommel B, Sharma A, Delagrange P, Arbez N, Moutin MJ, Peris L, Mikhaylova M
Journal of cell science (2024) : . 377 003 ICC; tested species: mouse
Centrosome-mediated microtubule remodeling during axon formation in human iPSC-derived neurons.
Lindhout FW, Portegies S, Kooistra R, Herstel LJ, Stucchi R, Hummel JJA, Scheefhals N, Katrukha EA, Altelaar M, MacGillavry HD, Wierenga CJ, et al.
The EMBO journal (2021) : e106798. 377 003 ICC; tested species: human,rat
Combined kinesin-1 and kinesin-3 activity drives axonal trafficking of TrkB receptors in Rab6 carriers.
Zahavi EE, Hummel JJA, Han Y, Bar C, Stucchi R, Altelaar M, Hoogenraad CC
Developmental cell (2021) : . 377 003 ICC; tested species: rat
Axonal TAU Sorting Requires the C-terminus of TAU but is Independent of ANKG and TRIM46 Enrichment at the AIS.
Bell M, Bachmann S, Klimek J, Langerscheidt F, Zempel H
Neuroscience (2021) 461: 155-171. 377 003 ICC; tested species: mouse
The Kohlschütter-Tönz syndrome associated gene Rogdi encodes a novel presynaptic protein.
Riemann D, Wallrafen R, Dresbach T
Scientific reports (2017) 71: 15791. 377 003 ICC; tested species: rat
Cat. No.: 377 003
Amount: 50 µg
Price: $375.00
Efficient axonal transport of endolysosomes relies on the balanced ratio of microtubule tyrosination and detyrosination.
Konietzny A, Han Y, Popp Y, van Bommel B, Sharma A, Delagrange P, Arbez N, Moutin MJ, Peris L, Mikhaylova M
Journal of cell science (2024) : . 377 003 ICC; tested species: mouse
Centrosome-mediated microtubule remodeling during axon formation in human iPSC-derived neurons.
Lindhout FW, Portegies S, Kooistra R, Herstel LJ, Stucchi R, Hummel JJA, Scheefhals N, Katrukha EA, Altelaar M, MacGillavry HD, Wierenga CJ, et al.
The EMBO journal (2021) : e106798. 377 003 ICC; tested species: human,rat
Combined kinesin-1 and kinesin-3 activity drives axonal trafficking of TrkB receptors in Rab6 carriers.
Zahavi EE, Hummel JJA, Han Y, Bar C, Stucchi R, Altelaar M, Hoogenraad CC
Developmental cell (2021) : . 377 003 ICC; tested species: rat
Axonal TAU Sorting Requires the C-terminus of TAU but is Independent of ANKG and TRIM46 Enrichment at the AIS.
Bell M, Bachmann S, Klimek J, Langerscheidt F, Zempel H
Neuroscience (2021) 461: 155-171. 377 003 ICC; tested species: mouse
The Kohlschütter-Tönz syndrome associated gene Rogdi encodes a novel presynaptic protein.
Riemann D, Wallrafen R, Dresbach T
Scientific reports (2017) 71: 15791. 377 003 ICC; tested species: rat
ICC
IHC
IHC-P
Background
The tripartite motif containing protein TRIM 46, also referred to as TRIFIC, is a member of the C-I TRIM family, a subfamily of the RBCC (N-terminal RING finger/B-box/coiled coil)/TRIM superfamily.
TRIM 46 localizes to newly specified axons and, at later stages, to the axon initial segment (AIS). By forming closely spaced parallel microtubule bundles it plays a crucial role in the initial polarization of neuronal cells.
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