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SY SY - Synaptic Systems SY SY - Synaptic Systems

TMEM 119 - 400 002

A microglia specific transmembrane protein

Polyclonal rabbit antiserum
350.00 USD
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Cat. No. 400 002 200 µl antiserum, lyophilized. For reconstitution add 200 µl H2O, then aliquot and store at -20°C until use.
Applications WB: not tested yet
IP: not tested yet
ICC: not tested yet
IHC: 1 : 500 up to 1 : 1000 (see remarks) gallery  
IHC-P/FFPE: 1 : 500      gallery  
Immunogen Recombinant protein corresponding to AA 189 to 280 from mouse TMEM119 (UniProt Id: Q8R138)
Reactivity Reacts with: mouse (Q8R138).
Weaker signal: rat (B2RYL3).
Other species not tested yet.
Specificity Specific for TMEM 119.
Remarks

This antibody is recommended for mouse only. Due to significant differences of TMEM 119 among species, cross-reactivity is unlikely.

IHC: The antiserum produces some unspecific background in the cerebellum.

Datasheet 400_002.pdf


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References for TMEM 119 - 400 002

Genetically induced brain inflammation by Cnp deletion transiently benefits from microglia depletion.
Garcia-Agudo LF, Janova H, Sendler LE, Arinrad S, Steixner AA, Hassouna I, Balmuth E, Ronnenberg A, Schopf N, van der Flier FJ, Begemann M, et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology (2019) : fj201900337R. 400 002 IHC; tested species: mouse
Complement 3+-astrocytes are highly abundant in prion diseases, but their abolishment led to an accelerated disease course and early dysregulation of microglia.
Hartmann K, Sepulveda-Falla D, Rose IVL, Madore C, Muth C, Matschke J, Butovsky O, Liddelow S, Glatzel M, Krasemann S
Acta neuropathologica communications (2019) 71: 83. 400 002 IHC; tested species: mouse
Microglia pre-activation and neurodegeneration precipitate neuroinflammation without exacerbating tissue injury in experimental autoimmune encephalomyelitis.
Wimmer I, Scharler C, Zrzavy T, Kadowaki T, Mödlagl V, Rojc K, Tröscher AR, Kitic M, Ueda S, Bradl M, Lassmann H, et al.
Acta neuropathologica communications (2019) 71: 14. 400 002 IHC-P; tested species: rat
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Synaptic Systems GmbH | Rudolf-Wissell-Str. 28 | 37079 Göttingen | Germany
Phone: +49 (0)551/505 56-0 | Internet: http://www.sysy.com | E-Mail: sales@sysy.com