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SY SY - Synaptic Systems SY SY - Synaptic Systems

α/β Synuclein - 128 002

Protein involved in Parkinson's and Alzheimer's Disease

Polyclonal rabbit antiserum
350.00 USD
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Cat. No. 128 002 200 µl antiserum, lyophilized. For reconstitution add 200 µl H2O, then aliquot and store at -20°C until use.
Applications WB: 1 : 1000 (AP staining) gallery  
IP: yes
ICC: 1 : 500 gallery  
IHC: 1 : 500 gallery  
IHC-P/FFPE: yes
Immunogen Synthetic peptide corresponding to AA 2 to 25 from human α-Synuclein (UniProt Id: P37840)
Reactivity Reacts with: rat (P37377, Q63754), mouse (O55042, Q91ZZ3), zebrafish, human (P37840, Q16143).
Other species not tested yet.
Specificity Recognizes α synuclein and β synuclein.
Datasheet 128_002.pdf


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References for alpha/beta Synuclein - 128 002

Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins.
Wilhelm BG, Mandad S, Truckenbrodt S, Kröhnert K, Schäfer C, Rammner B, Koo SJ, Claßen GA, Krauss M, Haucke V, Urlaub H, et al.
Science (New York, N.Y.) (2014) 3446187: 1023-8. 128 002 WB, ICC, IHC; tested species: mouse,rat
Over-expression of alpha-synuclein in the nervous system enhances axonal degeneration after peripheral nerve lesion in a transgenic mouse strain.
Siebert H, Kahle PJ, Kramer ML, Isik T, Schlüter OM, Schulz-Schaeffer WJ, Brück W
Journal of neurochemistry (2010) 1144: 1007-18. 128 002 WB
Brain alpha-synuclein accumulation in multiple system atrophy, Parkinson's disease and progressive supranuclear palsy: a comparative investigation.
Tong J, Wong H, Guttman M, Ang LC, Forno LS, Shimadzu M, Rajput AH, Muenter MD, Kish SJ, Hornykiewicz O, Furukawa Y, et al.
Brain : a journal of neurology (2010) 133Pt 1: 172-88. 128 002 WB; tested species: human
Mitochondrial translocation of alpha-synuclein is promoted by intracellular acidification.
Cole NB, Dieuliis D, Leo P, Mitchell DC, Nussbaum RL
Experimental cell research (2008) 31410: 2076-89. 128 002 WB, ICC, EM
Molecular anatomy of a trafficking organelle.
Takamori S, Holt M, Stenius K, Lemke EA, Grønborg M, Riedel D, Urlaub H, Schenck S, Brügger B, Ringler P, Müller SA, et al.
Cell (2006) 1274: 831-46. 128 002 WB
alpha-Synuclein protects SH-SY5Y cells from dopamine toxicity.
Colapinto M, Mila S, Giraudo S, Stefanazzi P, Molteni M, Rossetti C, Bergamasco B, Lopiano L, Fasano M
Biochemical and biophysical research communications (2006) 3494: 1294-300. 128 002 WB
Unchanged survival rates of 14-3-3gamma knockout mice after inoculation with pathological prion protein.
Steinacker P, Schwarz P, Reim K, Brechlin P, Jahn O, Kratzin H, Aitken A, Wiltfang J, Aguzzi A, Bahn E, Baxter HC, et al.
Molecular and cellular biology (2005) 254: 1339-46. 128 002 WB
A broken alpha -helix in folded alpha -Synuclein.
Chandra S, Chen X, Rizo J, Jahn R, Südhof TC
The Journal of biological chemistry (2003) 27817: 15313-8. 128 002 WB
Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins.
Wilhelm BG, Mandad S, Truckenbrodt S, Kröhnert K, Schäfer C, Rammner B, Koo SJ, Claßen GA, Krauss M, Haucke V, Urlaub H, et al.
Science (New York, N.Y.) (2014) 3446187: 1023-8. 128 002 WB, ICC, IHC; tested species: mouse,rat
Mitochondrial translocation of alpha-synuclein is promoted by intracellular acidification.
Cole NB, Dieuliis D, Leo P, Mitchell DC, Nussbaum RL
Experimental cell research (2008) 31410: 2076-89. 128 002 WB, ICC, EM
Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins.
Wilhelm BG, Mandad S, Truckenbrodt S, Kröhnert K, Schäfer C, Rammner B, Koo SJ, Claßen GA, Krauss M, Haucke V, Urlaub H, et al.
Science (New York, N.Y.) (2014) 3446187: 1023-8. 128 002 WB, ICC, IHC; tested species: mouse,rat
Mitochondrial translocation of alpha-synuclein is promoted by intracellular acidification.
Cole NB, Dieuliis D, Leo P, Mitchell DC, Nussbaum RL
Experimental cell research (2008) 31410: 2076-89. 128 002 WB, ICC, EM
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Synaptic Systems GmbH | Rudolf-Wissell-Str. 28 | 37079 Göttingen | Germany
Phone: +49 (0)551/505 56-0 | Internet: http://www.sysy.com | E-Mail: sales@sysy.com