Cat. No.: 110 403
Amount: 50 µg
Price:
$455.00
|
|
|
| Cat. No. 110 403 |
50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin was added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications | |
| Immunogen | Synthetic peptide corresponding to AA 171 to 187 from rat Syntaxin1B (UniProt Id: P61265) |
| Reactivity |
Reacts with: human (P61266), rat (P61265), mouse (P61264), hamster, cow, pig, chicken, zebrafish. Other species not tested yet. |
| Specificity | Specific for syntaxin 1B, no cross reactivity to syntaxin 1A. K.O. validated PubMed: 32572454 |
| Matching control protein/peptide | 110-1BP |
| Remarks |
ELISA: Suitable as detector antibody for sandwich-ELISA with cat. no. 110 011 as capture antibodies. The ELISA-protocol for membrane proteins is recommended. |
| Data sheet | 110_403.pdf |
|
|
Syntaxin 1, also known as p35, is a small integral membrane protein that is abundantly expressed in neurons and neuroendocrine cells. It was initially discovered as HPC-1. Syntaxin 1 is an essential component of the exocytotic fusion machine and interacts with several other proteins important for synaptic function, including its partners in the fusion complex synaptobrevin, SNAP 25, α-SNAP, synaptotagmin 1, Munc 18/n-Sec1 and Ca2+-channels.
Syntaxin 1 is localized primarily to the neuronal plasmalemma and is concentrated in synapses where pools of the protein are also present on recycling organelles including synaptic vesicles. It is the main target of one of the Botulinum neurotoxins BoNT/C1 which, however, cannot cleave the protein when complexed with its partner proteins in the fusion complex.