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Home > Products > 110 402

Syntaxin1B antibody - 110 402 K.O.

Syntaxin1 is a plasma membrane SNARE protein essential for synaptic vesicle fusion
Rabbit polyclonal antiserum
Cat. No.: 110 402
Amount: 200 µl
Price: $355.00
Cat. No. 110 402 200 µl antiserum, lyophilized. For reconstitution add 200 µl H2O, then aliquot and store at -20°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 1000 (AP staining) gallery  
IP: yes
ICC: 1 : 100 up to 1 : 1000 gallery  
IHC: 1 : 1000 gallery  
IHC-P: 1 : 500 gallery  
Immunogen Synthetic peptide corresponding to AA 171 to 187 from rat Syntaxin1B (UniProt Id: P61265)
Reactivity Reacts with: human (P61266), rat (P61265), mouse (P61264), hamster, cow, pig, chicken, zebrafish.
Other species not tested yet.
Specificity Specific for syntaxin 1B, no cross reactivity to syntaxin 1A. K.O. validated PubMed: 26203110
Matching control protein/peptide 110-1BP
Data sheet 110_402.pdf

References for Syntaxin1B - 110 402

Palmitoylation is required for Sept8-204 and Sept5 to form vesicle-like structure and colocalize with synaptophysin.
Liu H, Tan R, Tong J, Wen S, Wu C, Rao M, Zhu J, Qi S, Kong E
Journal of cellular biochemistry (2024) : . 110 402 WB; tested species: mouse
Syntabulin regulates neuronal excitation/inhibition balance and epileptic seizures by transporting syntaxin 1B.
Ke P, Gu J, Liu J, Liu Y, Tian X, Ma Y, Meng Y, Xiao F
Cell death discovery (2023) 91: 187. 110 402 WB, IP, ICC; tested species: mouse
Reduced synaptic proteins and SNARE complexes in Down syndrome with Alzheimer's disease and the Dp16 mouse Down syndrome model: Impact of APP gene dose.
Chen XQ, Zuo X, Becker A, Head E, Mobley WC
Alzheimer's & dementia : the journal of the Alzheimer's Association (2022) : . 110 402 WB; tested species: human,mouse
Pulse-Chase Proteomics of the App Knockin Mouse Models of Alzheimer's Disease Reveals that Synaptic Dysfunction Originates in Presynaptic Terminals.
Hark TJ, Rao NR, Castillon C, Basta T, Smukowski S, Bao H, Upadhyay A, Bomba-Warczak E, Nomura T, O'Toole ET, Morgan GP, et al.
Cell systems (2020) : . 110 402 WB, IHC; tested species: mouse
Tuning of glutamate, but not GABA, release by an intra-synaptic vesicles APP domain whose function can be modulated by β- or α-secretase cleavage.
Yao W, Tambini MD, Liu X, D'Adamio L
The Journal of neuroscience : the official journal of the Society for Neuroscience (2019) : . 110 402 WB; tested species: mouse
Syntaxin 1B is important for mouse postnatal survival and proper synaptic function at the mouse neuromuscular junctions.
Wu YJ, Tejero R, Arancillo M, Vardar G, Korotkova T, Kintscher M, Schmitz D, Ponomarenko A, Tabares L, Rosenmund C
Journal of neurophysiology (2015) 1144: 2404-17. 110 402 WB, IHC; KO verified
Quantitative Proteomic Analysis Reveals Molecular Adaptations in the Hippocampal Synaptic Active Zone of Chronic Mild Stress-Unsusceptible Rats.
Zhou J, Liu Z, Yu J, Han X, Fan S, Shao W, Chen J, Qiao R, Xie P
The international journal of neuropsychopharmacology (2015) 191: . 110 402 WB
Stapling of the botulinum type A protease to growth factors and neuropeptides allows selective targeting of neuroendocrine cells.
Arsenault J, Ferrari E, Niranjan D, Cuijpers SA, Gu C, Vallis Y, O'Brien J, Davletov B
Journal of neurochemistry (2013) 1262: 223-33. 110 402 WB
Syntaxin 1B suppresses macropinocytosis and semaphorin 3A-induced growth cone collapse.
Kabayama H, Takeuchi M, Taniguchi M, Tokushige N, Kozaki S, Mizutani A, Nakamura T, Mikoshiba K
The Journal of neuroscience : the official journal of the Society for Neuroscience (2011) 3120: 7357-64. 110 402 WB
How pig sperm prepares to fertilize: stable acrosome docking to the plasma membrane.
Tsai PS, Garcia-Gil N, van Haeften T, Gadella BM
PloS one (2010) 56: e11204. 110 402 WB, IP
Vesicle associated membrane protein (VAMP)-7 and VAMP-8, but not VAMP-2 or VAMP-3, are required for activation-induced degranulation of mature human mast cells.
Sander LE, Frank SP, Bolat S, Blank U, Galli T, Bigalke H, Bischoff SC, Lorentz A
European journal of immunology (2008) 383: 855-63. 110 402 WB; tested species: human
Retinal pigment epithelial cells exhibit unique expression and localization of plasma membrane syntaxins which may contribute to their trafficking phenotype.
Low SH, Marmorstein LY, Miura M, Li X, Kudo N, Marmorstein AD, Weimbs T
Journal of cell science (2002) 115Pt 23: 4545-53. 110 402 WB, IHC
Syntabulin regulates neuronal excitation/inhibition balance and epileptic seizures by transporting syntaxin 1B.
Ke P, Gu J, Liu J, Liu Y, Tian X, Ma Y, Meng Y, Xiao F
Cell death discovery (2023) 91: 187. 110 402 WB, IP, ICC; tested species: mouse
Co-immunoprecipitation with Tau Isoform-specific Antibodies Reveals Distinct Protein Interactions and Highlights a Putative Role for 2N Tau in Disease.
Liu C, Song X, Nisbet R, Götz J
The Journal of biological chemistry (2016) 29115: 8173-88. 110 402 IP
How pig sperm prepares to fertilize: stable acrosome docking to the plasma membrane.
Tsai PS, Garcia-Gil N, van Haeften T, Gadella BM
PloS one (2010) 56: e11204. 110 402 WB, IP
Syntabulin regulates neuronal excitation/inhibition balance and epileptic seizures by transporting syntaxin 1B.
Ke P, Gu J, Liu J, Liu Y, Tian X, Ma Y, Meng Y, Xiao F
Cell death discovery (2023) 91: 187. 110 402 WB, IP, ICC; tested species: mouse
SNAP23 deficiency causes severe brain dysplasia through the loss of radial glial cell polarity.
Kunii M, Noguchi Y, Yoshimura SI, Kanda S, Iwano T, Avriyanti E, Atik N, Sato T, Sato K, Ogawa M, Harada A, et al.
The Journal of cell biology (2021) 2201: . 110 402 ICC, IHC; KD verified; tested species: mouse
Dynamin controls neuropeptide secretion by organizing dense-core vesicle fusion sites.
Moro A, van Nifterick A, Toonen RF, Verhage M
Science advances (2021) 721: . 110 402 ICC; tested species: mouse
Novel cell types, neurosecretory cells, and body plan of the early-diverging metazoan Trichoplax adhaerens.
Smith CL, Varoqueaux F, Kittelmann M, Azzam RN, Cooper B, Winters CA, Eitel M, Fasshauer D, Reese TS
Current biology : CB (2014) 2414: 1565-1572. 110 402 ICC
SNAP23 deficiency causes severe brain dysplasia through the loss of radial glial cell polarity.
Kunii M, Noguchi Y, Yoshimura SI, Kanda S, Iwano T, Avriyanti E, Atik N, Sato T, Sato K, Ogawa M, Harada A, et al.
The Journal of cell biology (2021) 2201: . 110 402 ICC, IHC; KD verified; tested species: mouse
Pulse-Chase Proteomics of the App Knockin Mouse Models of Alzheimer's Disease Reveals that Synaptic Dysfunction Originates in Presynaptic Terminals.
Hark TJ, Rao NR, Castillon C, Basta T, Smukowski S, Bao H, Upadhyay A, Bomba-Warczak E, Nomura T, O'Toole ET, Morgan GP, et al.
Cell systems (2020) : . 110 402 WB, IHC; tested species: mouse
Syntaxin 1B is important for mouse postnatal survival and proper synaptic function at the mouse neuromuscular junctions.
Wu YJ, Tejero R, Arancillo M, Vardar G, Korotkova T, Kintscher M, Schmitz D, Ponomarenko A, Tabares L, Rosenmund C
Journal of neurophysiology (2015) 1144: 2404-17. 110 402 WB, IHC; KO verified
Rare autism-associated variants implicate syntaxin 1 (STX1 R26Q) phosphorylation and the dopamine transporter (hDAT R51W) in dopamine neurotransmission and behaviors.
Cartier E, Hamilton PJ, Belovich AN, Shekar A, Campbell NG, Saunders C, Andreassen TF, Gether U, Veenstra-Vanderweele J, Sutcliffe JS, Ulery-Reynolds PG, et al.
EBioMedicine (2015) 22: 135-146. 110 402 IHC; tested species: mouse
Retinal pigment epithelial cells exhibit unique expression and localization of plasma membrane syntaxins which may contribute to their trafficking phenotype.
Low SH, Marmorstein LY, Miura M, Li X, Kudo N, Marmorstein AD, Weimbs T
Journal of cell science (2002) 115Pt 23: 4545-53. 110 402 WB, IHC
Changes in retinal synaptic proteins in the transgenic model expressing a mutant HRG4 (UNC119).
Kubota S, Kobayashi A, Mori N, Higashide T, McLaren MJ, Inana G
Investigative ophthalmology & visual science (2002) 432: 308-13. 110 402 IHC
Synapsin-dependent reserve pool of synaptic vesicles supports replenishment of the readily releasable pool under intense synaptic transmission.
Vasileva M, Horstmann H, Geumann C, Gitler D, Kuner T
The European journal of neuroscience (2012) 368: 3005-20. 110 402 ELISA
Cat. No.: 110 402
Amount: 200 µl
Price: $355.00
Palmitoylation is required for Sept8-204 and Sept5 to form vesicle-like structure and colocalize with synaptophysin.
Liu H, Tan R, Tong J, Wen S, Wu C, Rao M, Zhu J, Qi S, Kong E
Journal of cellular biochemistry (2024) : . 110 402 WB; tested species: mouse
Syntabulin regulates neuronal excitation/inhibition balance and epileptic seizures by transporting syntaxin 1B.
Ke P, Gu J, Liu J, Liu Y, Tian X, Ma Y, Meng Y, Xiao F
Cell death discovery (2023) 91: 187. 110 402 WB, IP, ICC; tested species: mouse
Reduced synaptic proteins and SNARE complexes in Down syndrome with Alzheimer's disease and the Dp16 mouse Down syndrome model: Impact of APP gene dose.
Chen XQ, Zuo X, Becker A, Head E, Mobley WC
Alzheimer's & dementia : the journal of the Alzheimer's Association (2022) : . 110 402 WB; tested species: human,mouse
Pulse-Chase Proteomics of the App Knockin Mouse Models of Alzheimer's Disease Reveals that Synaptic Dysfunction Originates in Presynaptic Terminals.
Hark TJ, Rao NR, Castillon C, Basta T, Smukowski S, Bao H, Upadhyay A, Bomba-Warczak E, Nomura T, O'Toole ET, Morgan GP, et al.
Cell systems (2020) : . 110 402 WB, IHC; tested species: mouse
Tuning of glutamate, but not GABA, release by an intra-synaptic vesicles APP domain whose function can be modulated by β- or α-secretase cleavage.
Yao W, Tambini MD, Liu X, D'Adamio L
The Journal of neuroscience : the official journal of the Society for Neuroscience (2019) : . 110 402 WB; tested species: mouse
Syntaxin 1B is important for mouse postnatal survival and proper synaptic function at the mouse neuromuscular junctions.
Wu YJ, Tejero R, Arancillo M, Vardar G, Korotkova T, Kintscher M, Schmitz D, Ponomarenko A, Tabares L, Rosenmund C
Journal of neurophysiology (2015) 1144: 2404-17. 110 402 WB, IHC; KO verified
Quantitative Proteomic Analysis Reveals Molecular Adaptations in the Hippocampal Synaptic Active Zone of Chronic Mild Stress-Unsusceptible Rats.
Zhou J, Liu Z, Yu J, Han X, Fan S, Shao W, Chen J, Qiao R, Xie P
The international journal of neuropsychopharmacology (2015) 191: . 110 402 WB
Stapling of the botulinum type A protease to growth factors and neuropeptides allows selective targeting of neuroendocrine cells.
Arsenault J, Ferrari E, Niranjan D, Cuijpers SA, Gu C, Vallis Y, O'Brien J, Davletov B
Journal of neurochemistry (2013) 1262: 223-33. 110 402 WB
Syntaxin 1B suppresses macropinocytosis and semaphorin 3A-induced growth cone collapse.
Kabayama H, Takeuchi M, Taniguchi M, Tokushige N, Kozaki S, Mizutani A, Nakamura T, Mikoshiba K
The Journal of neuroscience : the official journal of the Society for Neuroscience (2011) 3120: 7357-64. 110 402 WB
How pig sperm prepares to fertilize: stable acrosome docking to the plasma membrane.
Tsai PS, Garcia-Gil N, van Haeften T, Gadella BM
PloS one (2010) 56: e11204. 110 402 WB, IP
Vesicle associated membrane protein (VAMP)-7 and VAMP-8, but not VAMP-2 or VAMP-3, are required for activation-induced degranulation of mature human mast cells.
Sander LE, Frank SP, Bolat S, Blank U, Galli T, Bigalke H, Bischoff SC, Lorentz A
European journal of immunology (2008) 383: 855-63. 110 402 WB; tested species: human
Retinal pigment epithelial cells exhibit unique expression and localization of plasma membrane syntaxins which may contribute to their trafficking phenotype.
Low SH, Marmorstein LY, Miura M, Li X, Kudo N, Marmorstein AD, Weimbs T
Journal of cell science (2002) 115Pt 23: 4545-53. 110 402 WB, IHC
Syntabulin regulates neuronal excitation/inhibition balance and epileptic seizures by transporting syntaxin 1B.
Ke P, Gu J, Liu J, Liu Y, Tian X, Ma Y, Meng Y, Xiao F
Cell death discovery (2023) 91: 187. 110 402 WB, IP, ICC; tested species: mouse
Co-immunoprecipitation with Tau Isoform-specific Antibodies Reveals Distinct Protein Interactions and Highlights a Putative Role for 2N Tau in Disease.
Liu C, Song X, Nisbet R, Götz J
The Journal of biological chemistry (2016) 29115: 8173-88. 110 402 IP
How pig sperm prepares to fertilize: stable acrosome docking to the plasma membrane.
Tsai PS, Garcia-Gil N, van Haeften T, Gadella BM
PloS one (2010) 56: e11204. 110 402 WB, IP
Syntabulin regulates neuronal excitation/inhibition balance and epileptic seizures by transporting syntaxin 1B.
Ke P, Gu J, Liu J, Liu Y, Tian X, Ma Y, Meng Y, Xiao F
Cell death discovery (2023) 91: 187. 110 402 WB, IP, ICC; tested species: mouse
SNAP23 deficiency causes severe brain dysplasia through the loss of radial glial cell polarity.
Kunii M, Noguchi Y, Yoshimura SI, Kanda S, Iwano T, Avriyanti E, Atik N, Sato T, Sato K, Ogawa M, Harada A, et al.
The Journal of cell biology (2021) 2201: . 110 402 ICC, IHC; KD verified; tested species: mouse
Dynamin controls neuropeptide secretion by organizing dense-core vesicle fusion sites.
Moro A, van Nifterick A, Toonen RF, Verhage M
Science advances (2021) 721: . 110 402 ICC; tested species: mouse
Novel cell types, neurosecretory cells, and body plan of the early-diverging metazoan Trichoplax adhaerens.
Smith CL, Varoqueaux F, Kittelmann M, Azzam RN, Cooper B, Winters CA, Eitel M, Fasshauer D, Reese TS
Current biology : CB (2014) 2414: 1565-1572. 110 402 ICC
SNAP23 deficiency causes severe brain dysplasia through the loss of radial glial cell polarity.
Kunii M, Noguchi Y, Yoshimura SI, Kanda S, Iwano T, Avriyanti E, Atik N, Sato T, Sato K, Ogawa M, Harada A, et al.
The Journal of cell biology (2021) 2201: . 110 402 ICC, IHC; KD verified; tested species: mouse
Pulse-Chase Proteomics of the App Knockin Mouse Models of Alzheimer's Disease Reveals that Synaptic Dysfunction Originates in Presynaptic Terminals.
Hark TJ, Rao NR, Castillon C, Basta T, Smukowski S, Bao H, Upadhyay A, Bomba-Warczak E, Nomura T, O'Toole ET, Morgan GP, et al.
Cell systems (2020) : . 110 402 WB, IHC; tested species: mouse
Syntaxin 1B is important for mouse postnatal survival and proper synaptic function at the mouse neuromuscular junctions.
Wu YJ, Tejero R, Arancillo M, Vardar G, Korotkova T, Kintscher M, Schmitz D, Ponomarenko A, Tabares L, Rosenmund C
Journal of neurophysiology (2015) 1144: 2404-17. 110 402 WB, IHC; KO verified
Rare autism-associated variants implicate syntaxin 1 (STX1 R26Q) phosphorylation and the dopamine transporter (hDAT R51W) in dopamine neurotransmission and behaviors.
Cartier E, Hamilton PJ, Belovich AN, Shekar A, Campbell NG, Saunders C, Andreassen TF, Gether U, Veenstra-Vanderweele J, Sutcliffe JS, Ulery-Reynolds PG, et al.
EBioMedicine (2015) 22: 135-146. 110 402 IHC; tested species: mouse
Retinal pigment epithelial cells exhibit unique expression and localization of plasma membrane syntaxins which may contribute to their trafficking phenotype.
Low SH, Marmorstein LY, Miura M, Li X, Kudo N, Marmorstein AD, Weimbs T
Journal of cell science (2002) 115Pt 23: 4545-53. 110 402 WB, IHC
Changes in retinal synaptic proteins in the transgenic model expressing a mutant HRG4 (UNC119).
Kubota S, Kobayashi A, Mori N, Higashide T, McLaren MJ, Inana G
Investigative ophthalmology & visual science (2002) 432: 308-13. 110 402 IHC
Synapsin-dependent reserve pool of synaptic vesicles supports replenishment of the readily releasable pool under intense synaptic transmission.
Vasileva M, Horstmann H, Geumann C, Gitler D, Kuner T
The European journal of neuroscience (2012) 368: 3005-20. 110 402 ELISA
WB
ICC
IHC
IHC-P
Background

Syntaxin 1, also known as p35, is a small integral membrane protein that is abundantly expressed in neurons and neuroendocrine cells. It was initially discovered as HPC-1. Syntaxin 1 is an essential component of the exocytotic fusion machine and interacts with several other proteins important for synaptic function, including its partners in the fusion complex synaptobrevin, SNAP 25, α-SNAP, synaptotagmin 1, Munc 18/n-Sec1 and Ca2+-channels.
Syntaxin 1 is localized primarily to the neuronal plasmalemma and is concentrated in synapses where pools of the protein are also present on recycling organelles including synaptic vesicles. It is the main target of one of the Botulinum neurotoxins BoNT/C1 which, however, cannot cleave the protein when complexed with its partner proteins in the fusion complex.
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