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SynGAP antibody - 157 002

SynGAP is a synaptic Ras-GTPase activating protein
Rabbit polyclonal antiserum
Cat. No.: 157 002
Amount: 200 µl
Price: $355.00
Cat. No. 157 002 200 µl antiserum, lyophilized. For reconstitution add 200 µl H2O, then aliquot and store at -20°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 500 up to 1 : 2000 (AP staining) gallery  
IP: not tested yet
ICC: not tested yet
IHC: not tested yet
IHC-P: not tested yet
Immunogen Synthetic peptide corresponding to AA 1274 to 1293 from rat SynGAP (UniProt Id: Q9QUH6)
Reactivity Reacts with: rat (Q9QUH6).
Other species not tested yet.
Specificity Recognizes both isofoms SynGAP a and b.
Matching control protein/peptide 157-0P
Data sheet 157_002.pdf
Cat. No.: 157 002
Amount: 200 µl
Price: $355.00
Background

SynGAP is an approximately 135 kDa protein which is condensed at the post-synaptic density. A potential interaction partner for this protein is the abundant PDZ domain protein PSD 95.
Three isoforms (a, b and c) of synGAP have been described. The protein is a substrate for calmodulin dependent kinase 2 (CAMK2). Phosphorylation of synGAP reduces its activity, leading to an increased activation of Ras.