Cat. No.: 106 203
Amount: 50 µg
Price:
$375.00
|
|
|
| Cat. No. 106 203 |
50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin was added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications | |
| Immunogen | Synthetic peptide corresponding to AA 440 to 458 from rat Synapsin2 (UniProt Id: Q63537-1) |
| Reactivity |
Reacts with: human (Q92777), rat (Q63537), mouse (Q64332), pig. Other species not tested yet. |
| Specificity | Specific for synapsins 2a and 2b, no cross-reactivity to synapsin 1a/b. K.O. validated PubMed: 26177381 |
| Matching control protein/peptide | 106-2P |
| Data sheet | 106_203.pdf |
|
|
Synapsins are neuron-specific phosphoproteins that are exclusively associated with small synaptic vesicles, with little or no expression in other tissues including neuroendocrine cells. In mammals, three distinct synapsin genes (synapsin 1, 2 and 3) encode more than eight neuronal isoforms.
Synapsin 1 is one of the most specific markers of synapses throughout the central and peripheral nervous system. In addition to synaptic nerve terminals, the protein is also present in certain sensory nerve endings. It is expressed in two splice variants (synapsin 1a and synapsin 1b). Synapsin 1 interacts with vesicle membranes as well as with actin and spectrin.
Synapsin 2 is expressed in the nervous system and also two splice variants were described so far, while synapsin 3 shows a more restricted expression pattern and is mainly found in the hypocampus.
Synapsins are major phosphoproteins and are substrates for several protein kinases such as PKA, CaMK I and CaMK II. Synapsin 1 is widely used as reference substrate for calmodulin-dependent protein kinases.