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SY SY - Synaptic Systems SY SY - Synaptic Systems

Synapsin 1/2 - 106 002

Peripheral synaptic vesicle proteins; substrate for several protein kinases

Polyclonal rabbit antiserum
350.00 USD
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Cat. No. 106 002 200 µl antiserum, lyophilized. For reconstitution add 200 µl H2O, then aliquot and store at -20°C until use.
Applications WB: 1 : 1000 (AP staining) gallery  
IP: yes
ICC: 1 : 500 gallery  
IHC: 1 : 500 gallery  
IHC-P/FFPE: 1 : 500 gallery  
ELISA: yes (see remarks)
Immunogen Synthetic peptide corresponding to AA 2 to 28 from rat Synapsin1 (UniProt Id: P09951)
Reactivity Reacts with: human (P17600, Q92777), rat (P09951, Q63537), mouse (O88935, Q64332), hamster, cow, zebrafish.
Other species not tested yet.
zebrafish image
Specificity Specific for synapsins 1a/b and 2a/b. (K.O. verified)
matching control protein/peptide 106-0P
Remarks

ELISA: Suitable as detector antibody for sandwich-ELISA with cat. no. 106 001 as capture antibody (protocol for sandwich-ELISA).

Datasheet 106_002.pdf


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References for Synapsin 1/2 - 106 002

Inhibition of colony-stimulating factor 1 receptor early in disease ameliorates motor deficits in SCA1 mice.
Qu W, Johnson A, Kim JH, Lukowicz A, Svedberg D, Cvetanovic M
Journal of neuroinflammation (2017) 141: 107. 106 002 WB; tested species: mouse
Liprin-α2 promotes the presynaptic recruitment and turnover of RIM1/CASK to facilitate synaptic transmission.
Spangler SA, Schmitz SK, Kevenaar JT, de Graaff E, de Wit H, Demmers J, Toonen RF, Hoogenraad CC
The Journal of cell biology (2013) 2016: 915-28. 106 002 WB, ICC; tested species: rat
Long-lasting hippocampal synaptic protein loss in a mouse model of posttraumatic stress disorder.
Herrmann L, Ionescu IA, Henes K, Golub Y, Wang NX, Buell DR, Holsboer F, Wotjak CT, Schmidt U
PloS one (2012) 78: e42603. 106 002 WB, IHC; tested species: mouse
Extensive remodeling of the presynaptic cytomatrix upon homeostatic adaptation to network activity silencing.
Lazarevic V, Schöne C, Heine M, Gundelfinger ED, Fejtova A
The Journal of neuroscience : the official journal of the Society for Neuroscience (2011) 3128: 10189-200. 106 002 WB, ICC
Identification of an endogenous substrate of zebrafish doublecortin-like protein kinase using a highly active truncation mutant.
Shimomura S, Nagamine T, Hatano N, Sueyoshi N, Kameshita I
Journal of biochemistry (2010) 1475: 711-22. 106 002 WB; tested species: zebrafish
SV2B regulates synaptotagmin 1 by direct interaction.
Lazzell DR, Belizaire R, Thakur P, Sherry DM, Janz R
The Journal of biological chemistry (2004) 27950: 52124-31. 106 002 WB; tested species: mouse
Cytosolic Trapping of a Mitochondrial Heat Shock Protein Is an Early Pathological Event in Synucleinopathies.
Szegő ÉM, Dominguez-Meijide A, Gerhardt E, König A, Koss DJ, Li W, Pinho R, Fahlbusch C, Johnson M, Santos P, Villar-Piqué A, et al.
Cell reports (2019) 281: 65-77.e6. 106 002 ICC; tested species: rat
Epitope specificity of anti-synapsin autoantibodies: Differential targeting of synapsin I domains.
Mertens R, Melchert S, Gitler D, Schou MB, Saether SG, Vaaler A, Piepgras J, Kochova E, Benfenati F, Ahnert-Hilger G, Ruprecht K, et al.
PloS one (2018) 1312: e0208636. 106 002 ICC; tested species: human
Newly produced synaptic vesicle proteins are preferentially used in synaptic transmission.
Truckenbrodt S, Viplav A, Jähne S, Vogts A, Denker A, Wildhagen H, Fornasiero EF, Rizzoli SO
The EMBO journal (2018) : . 106 002 ICC; tested species: rat
SUMO1-conjugation is altered during normal aging but not by increased amyloid burden.
Stankova T, Piepkorn L, Bayer TA, Jahn O, Tirard M
Aging cell (2018) : e12760. 106 002 ICC; tested species: mouse
α-Actinin Anchors PSD-95 at Postsynaptic Sites.
Matt L, Kim K, Hergarden AC, Patriarchi T, Malik ZA, Park DK, Chowdhury D, Buonarati OR, Henderson PB, Gökçek Saraç Ç, Zhang Y, et al.
Neuron (2018) 975: 1094-1109.e9. 106 002 ICC; tested species: rat
Caldendrin Directly Couples Postsynaptic Calcium Signals to Actin Remodeling in Dendritic Spines.
Mikhaylova M, Bär J, van Bommel B, Schätzle P, YuanXiang P, Raman R, Hradsky J, Konietzny A, Loktionov EY, Reddy PP, Lopez-Rojas J, et al.
Neuron (2018) 975: 1110-1125.e14. 106 002 ICC; tested species: mouse
Analysis of SUMO1-conjugation at synapses.
Daniel JA, Cooper BH, Palvimo JJ, Zhang FP, Brose N, Tirard M
eLife (2017) 6: . 106 002 ICC; tested species: mouse
Astrocyte VAMP3 vesicles undergo Ca2+ -independent cycling and modulate glutamate transporter trafficking.
Li D, Hérault K, Zylbersztejn K, Lauterbach MA, Guillon M, Oheim M, Ropert N
The Journal of physiology (2015) 59313: 2807-32. 106 002 ICC
Munc18-1 redistributes in nerve terminals in an activity- and PKC-dependent manner.
Cijsouw T, Weber JP, Broeke JH, Broek JA, Schut D, Kroon T, Saarloos I, Verhage M, Toonen RF
The Journal of cell biology (2014) 2045: 759-75. 106 002 ICC; tested species: mouse
Fragile X mental retardation protein controls synaptic vesicle exocytosis by modulating N-type calcium channel density.
Ferron L, Nieto-Rostro M, Cassidy JS, Dolphin AC
Nature communications (2014) 5: 3628. 106 002 ICC
A new probe for super-resolution imaging of membranes elucidates trafficking pathways.
Revelo NH, Kamin D, Truckenbrodt S, Wong AB, Reuter-Jessen K, Reisinger E, Moser T, Rizzoli SO
The Journal of cell biology (2014) 2054: 591-606. 106 002 ICC
Differential control of thrombospondin over synaptic glycine and AMPA receptors in spinal cord neurons.
Hennekinne L, Colasse S, Triller A, Renner M
The Journal of neuroscience : the official journal of the Society for Neuroscience (2013) 3328: 11432-9. 106 002 ICC; tested species: rat
Comprehensive expression analyses of neural cell-type-specific miRNAs identify new determinants of the specification and maintenance of neuronal phenotypes.
Jovičić A, Roshan R, Moisoi N, Pradervand S, Moser R, Pillai B, Luthi-Carter R
The Journal of neuroscience : the official journal of the Society for Neuroscience (2013) 3312: 5127-37. 106 002 ICC; tested species: rat
Liprin-α2 promotes the presynaptic recruitment and turnover of RIM1/CASK to facilitate synaptic transmission.
Spangler SA, Schmitz SK, Kevenaar JT, de Graaff E, de Wit H, Demmers J, Toonen RF, Hoogenraad CC
The Journal of cell biology (2013) 2016: 915-28. 106 002 WB, ICC; tested species: rat
Effects of erythropoietin in murine-induced pluripotent cell-derived panneural progenitor cells.
Offen N, Flemming J, Kamawal H, Ahmad R, Wolber W, Geis C, Zaehres H, Schöler HR, Ehrenreich H, Müller AM, Sirén AL, et al.
Molecular medicine (Cambridge, Mass.) (2013) 19: 399-408. 106 002 ICC; tested species: mouse
Phenotype and Stability of Neural Differentiation of Androgenetic Murine ES Cell-Derived Neural Progenitor Cells.
Wolber W, Ahmad R, Choi SW, Eckardt S, McLaughlin KJ, Schmitt J, Geis C, Heckmann M, Sirén AL, Müller AM
Cell medicine (2013) 51: 29-42. 106 002 ICC; tested species: mouse
Lateral mobility of presynaptic α7-containing nicotinic receptors and its relevance for glutamate release.
Gomez-Varela D, Berg DK
The Journal of neuroscience : the official journal of the Society for Neuroscience (2013) 3343: 17062-71. 106 002 ICC; tested species: rat
Neuronal profilin isoforms are addressed by different signalling pathways.
Murk K, Wittenmayer N, Michaelsen-Preusse K, Dresbach T, Schoenenberger CA, Korte M, Jockusch BM, Rothkegel M
PloS one (2012) 73: e34167. 106 002 ICC; tested species: mouse,rat
N-methyl-D-aspartate receptor antibodies in herpes simplex encephalitis.
Prüss H, Finke C, Höltje M, Hofmann J, Klingbeil C, Probst C, Borowski K, Ahnert-Hilger G, Harms L, Schwab JM, Ploner CJ, et al.
Annals of neurology (2012) 726: 902-11. 106 002 ICC
Hindered submicron mobility and long-term storage of presynaptic dense-core granules revealed by single-particle tracking.
Scalettar BA, Jacobs C, Fulwiler A, Prahl L, Simon A, Hilken L, Lochner JE
Developmental neurobiology (2012) 729: 1181-95. 106 002 ICC
Extensive remodeling of the presynaptic cytomatrix upon homeostatic adaptation to network activity silencing.
Lazarevic V, Schöne C, Heine M, Gundelfinger ED, Fejtova A
The Journal of neuroscience : the official journal of the Society for Neuroscience (2011) 3128: 10189-200. 106 002 WB, ICC
In vivo imaging of intersynaptic vesicle exchange using VGLUT1 Venus knock-in mice.
Herzog E, Nadrigny F, Silm K, Biesemann C, Helling I, Bersot T, Steffens H, Schwartzmann R, Nägerl UV, El Mestikawy S, Rhee J, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2011) 3143: 15544-59. 106 002 ICC; tested species: mouse
Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls neurite development.
Kawabe H, Neeb A, Dimova K, Young SM, Takeda M, Katsurabayashi S, Mitkovski M, Malakhova OA, Zhang DE, Umikawa M, Kariya K, et al.
Neuron (2010) 653: 358-72. 106 002 ICC; tested species: mouse
SynCAMs organize synapses through heterophilic adhesion.
Fogel AI, Akins MR, Krupp AJ, Stagi M, Stein V, Biederer T
The Journal of neuroscience : the official journal of the Society for Neuroscience (2007) 2746: 12516-30. 106 002 ICC
Immunolocalization of BK channels in hippocampal pyramidal neurons.
Sailer CA, Kaufmann WA, Kogler M, Chen L, Sausbier U, Ottersen OP, Ruth P, Shipston MJ, Knaus HG
The European journal of neuroscience (2006) 242: 442-54. 106 002 ICC; tested species: mouse
MACF1 links Rapsyn to microtubule- and actin-binding proteins to maintain neuromuscular synapses.
Oury J, Liu Y, Töpf A, Todorovic S, Hoedt E, Preethish-Kumar V, Neubert TA, Lin W, Lochmüller H, Burden SJ
The Journal of cell biology (2019) : . 106 002 IHC; tested species: mouse
Analysis of Synapses in Cerebral Organoids.
Yakoub AM, Sadek M
Cell transplantation (2019) : 963689718822811. 106 002 IHC; tested species: human
Synaptic-like Vesicles Facilitate Pioneer Axon Invasion.
Nichols EL, Smith CJ
Current biology : CB (2019) : . 106 002 IHC; tested species: zebrafish
Vezatin is Required for the Maturation of the Neuromuscular Synapse.
Koppel N, Friese MB, Cardasis HL, Neubert TA, Burden SJ
Molecular biology of the cell (2019) : mbcE19060313. 106 002 IHC; tested species: mouse
Transgenic FingRs for Live Mapping of Synaptic Dynamics in Genetically-Defined Neurons.
Son JH, Keefe MD, Stevenson TJ, Barrios JP, Anjewierden S, Newton JB, Douglass AD, Bonkowsky JL
Scientific reports (2016) 6: 18734. 106 002 IHC
Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins.
Wilhelm BG, Mandad S, Truckenbrodt S, Kröhnert K, Schäfer C, Rammner B, Koo SJ, Claßen GA, Krauss M, Haucke V, Urlaub H, et al.
Science (New York, N.Y.) (2014) 3446187: 1023-8. 106 002 IHC; tested species: mouse
Metabolic Maturation of Auditory Neurones in the Superior Olivary Complex.
Trattner B, Gravot CM, Grothe B, Kunz L
PloS one (2013) 86: e67351. 106 002 IHC; tested species: mouse
Lack of evidence for vesicular glutamate transporter expression in mouse astrocytes.
Li D, Hérault K, Silm K, Evrard A, Wojcik S, Oheim M, Herzog E, Ropert N
The Journal of neuroscience : the official journal of the Society for Neuroscience (2013) 3310: 4434-55. 106 002 IHC; tested species: mouse
Neonatal leptin exposure specifies innervation of presympathetic hypothalamic neurons and improves the metabolic status of leptin-deficient mice.
Bouyer K, Simerly RB
The Journal of neuroscience : the official journal of the Society for Neuroscience (2013) 332: 840-51. 106 002 IHC; tested species: mouse
Late recruitment of synapsin to nascent synapses is regulated by Cdk5.
Easley-Neal C, Fierro J, Buchanan J, Washbourne P
Cell reports (2013) 34: 1199-212. 106 002 IHC; tested species: zebrafish
Long-lasting hippocampal synaptic protein loss in a mouse model of posttraumatic stress disorder.
Herrmann L, Ionescu IA, Henes K, Golub Y, Wang NX, Buell DR, Holsboer F, Wotjak CT, Schmidt U
PloS one (2012) 78: e42603. 106 002 WB, IHC; tested species: mouse
Aberrant morphology and residual transmitter release at the Munc13-deficient mouse neuromuscular synapse.
Varoqueaux F, Sons MS, Plomp JJ, Brose N
Molecular and cellular biology (2005) 2514: 5973-84. 106 002 IHC
Changes in retinal synaptic proteins in the transgenic model expressing a mutant HRG4 (UNC119).
Kubota S, Kobayashi A, Mori N, Higashide T, McLaren MJ, Inana G
Investigative ophthalmology & visual science (2002) 432: 308-13. 106 002 IHC
Synapsin-dependent reserve pool of synaptic vesicles supports replenishment of the readily releasable pool under intense synaptic transmission.
Vasileva M, Horstmann H, Geumann C, Gitler D, Kuner T
The European journal of neuroscience (2012) 368: 3005-20. 106 002 ELISA
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Synaptic Systems GmbH | Rudolf-Wissell-Str. 28 | 37079 Göttingen | Germany
Phone: +49 (0)551/505 56-0 | Internet: http://www.sysy.com | E-Mail: sales@sysy.com