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Home > Products > 119 204

SV2 C antibody - 119 204

SV2s are highly glycosylated synaptic vesicle proteins with homology to transmembrane transporters
Guinea pig polyclonal antiserum
Cat. No.: 119 204
Amount: 100 µl
Price: $365.00
Cat. No. 119 204 100 µl antiserum, lyophilized. For reconstitution add 100 µl H2O, then aliquot and store at -20°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 1000 (AP staining) (see remarks) gallery  
IP: yes
ICC: 1 : 500 gallery  
IHC: 1 : 200 gallery  
IHC-P: 1 : 200 gallery  
Immunogen Synthetic peptide corresponding to AA 2 to 16 from rat SV2C (UniProt Id: Q9Z2I6)
Reactivity Reacts with: human (Q496J9), rat (Q9Z2I6), mouse (Q69ZS6).
Other species not tested yet.
Matching control protein/peptide 119-2P
Remarks

WB:  SV2 C aggregates after boiling, making it necessary to run SDS-PAGE with non-boiled samples.
Data sheet 119_204.pdf
Cat. No.: 119 204
Amount: 100 µl
Price: $365.00
WB
ICC
IHC
IHC-P
Background
SV2s (synaptic vesicle protein 2) are integral membrane glycoproteins present in all synaptic vesicles. They have 12 transmembrane domains predicted by sequence analysis. There are three characterized isoforms, SV2 A, SV2 B and SV2 C. SV2 A is expressed ubiquitously throughout the brain and is probably involved in the maintenance of a pool of synaptic vesicles competent for calcium- stimulated exocytosis. SV2 B has a more restricted distribution with varying degrees of coexpression with SV2 A. SV2 C is more closely related to SV2 A but shows a very restricted expression pattern. The highest expression levels were observed in phylogenetically old brain areas like pallidum, the midbrain and the olfactory bulb. SV2 expression has also been observed in other organs. In kidney it localizes to podocytes.
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