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Home > Products > 119 203

SV2 C antibody - 119 203

SV2s are highly glycosylated synaptic vesicle proteins with homology to transmembrane transporters
Rabbit polyclonal purified antibody
Cat. No.: 119 203
Amount: 50 µg
Price: $455.00
Cat. No. 119 203 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin was added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 1000 (AP staining) (see remarks)
IP: yes
ICC: 1 : 500 gallery  
IHC: 1 : 200 gallery  
IHC-P: 1 : 200 gallery  
Immunogen Synthetic peptide corresponding to AA 2 to 16 from rat SV2C (UniProt Id: Q9Z2I6)
Reactivity Reacts with: human (Q496J9), rat (Q9Z2I6), mouse (Q69ZS6), cow, dog.
Other species not tested yet.
Matching control protein/peptide 119-2P
Remarks

WB:  SV2 C aggregates after boiling, making it necessary to run SDS-PAGE with non-boiled samples.
Data sheet 119_203.pdf

References for SV2 C - 119 203

Human-Relevant Sensitivity of iPSC-Derived Human Motor Neurons to BoNT/A1 and B1.
Schenke M, Prause HC, Bergforth W, Przykopanski A, Rummel A, Klawonn F, Seeger B
Toxins (2021) 138: . 119 203 WB; tested species: human
Tuning of glutamate, but not GABA, release by an intra-synaptic vesicles APP domain whose function can be modulated by β- or α-secretase cleavage.
Yao W, Tambini MD, Liu X, D'Adamio L
The Journal of neuroscience : the official journal of the Society for Neuroscience (2019) : . 119 203 WB; tested species: mouse
Presynaptic targeting of botulinum neurotoxin type A requires a tripartite PSG-Syt1-SV2 plasma membrane nanocluster for synaptic vesicle entry.
Joensuu M, Syed P, Saber SH, Lanoue V, Wallis TP, Rae J, Blum A, Gormal RS, Small C, Sanders S, Jiang A, et al.
The EMBO journal (2023) : e112095. 119 203 ICC; tested species: rat
Tetanus Toxin cis-Loop Contributes to Light-Chain Translocation.
Zuverink M, Bluma M, Barbieri JT
mSphere (2020) 53: . 119 203 ICC; tested species: mouse
Entry of a recombinant, full-length, atoxic tetanus neurotoxin into Neuro-2a cells.
Blum FC, Przedpelski A, Tepp WH, Johnson EA, Barbieri JT
Infection and immunity (2014) 822: 873-81. 119 203 ICC; tested species: mouse
Cat. No.: 119 203
Amount: 50 µg
Price: $455.00
Human-Relevant Sensitivity of iPSC-Derived Human Motor Neurons to BoNT/A1 and B1.
Schenke M, Prause HC, Bergforth W, Przykopanski A, Rummel A, Klawonn F, Seeger B
Toxins (2021) 138: . 119 203 WB; tested species: human
Tuning of glutamate, but not GABA, release by an intra-synaptic vesicles APP domain whose function can be modulated by β- or α-secretase cleavage.
Yao W, Tambini MD, Liu X, D'Adamio L
The Journal of neuroscience : the official journal of the Society for Neuroscience (2019) : . 119 203 WB; tested species: mouse
Presynaptic targeting of botulinum neurotoxin type A requires a tripartite PSG-Syt1-SV2 plasma membrane nanocluster for synaptic vesicle entry.
Joensuu M, Syed P, Saber SH, Lanoue V, Wallis TP, Rae J, Blum A, Gormal RS, Small C, Sanders S, Jiang A, et al.
The EMBO journal (2023) : e112095. 119 203 ICC; tested species: rat
Tetanus Toxin cis-Loop Contributes to Light-Chain Translocation.
Zuverink M, Bluma M, Barbieri JT
mSphere (2020) 53: . 119 203 ICC; tested species: mouse
Entry of a recombinant, full-length, atoxic tetanus neurotoxin into Neuro-2a cells.
Blum FC, Przedpelski A, Tepp WH, Johnson EA, Barbieri JT
Infection and immunity (2014) 822: 873-81. 119 203 ICC; tested species: mouse
ICC
IHC
IHC-P
Background
SV2s (synaptic vesicle protein 2) are integral membrane glycoproteins present in all synaptic vesicles. They have 12 transmembrane domains predicted by sequence analysis. There are three characterized isoforms, SV2 A, SV2 B and SV2 C. SV2 A is expressed ubiquitously throughout the brain and is probably involved in the maintenance of a pool of synaptic vesicles competent for calcium- stimulated exocytosis. SV2 B has a more restricted distribution with varying degrees of coexpression with SV2 A. SV2 C is more closely related to SV2 A but shows a very restricted expression pattern. The highest expression levels were observed in phylogenetically old brain areas like pallidum, the midbrain and the olfactory bulb. SV2 expression has also been observed in other organs. In kidney it localizes to podocytes.
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