Synaptic Systems - Somatostatin-28

Cat. No.: 366 006

Amount: 200 µl

Price: $385.00

For the import of chicken antibodies into the USA you need a special import permit. This can be applied for at your USDA office. If you cannot apply for this, please order the chicken antibodies through our distributor Cedarlane USA. If you have any questions, please contact us.

Cat. No. 366 006	200 µl specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 200 µl H₂O. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications	WB: not recommended IP: not tested yet ICC: 1 : 500 up to 1 : 1000 gallery IHC: 1 : 500 up to 1 : 1000 gallery IHC-P: 1 : 500 up to 1 : 1000 gallery ExM: (see remarks) Western blot (WB); separation of proteins by PAGE and subsequent transfer to a membrane. Detection of target molecules is carried out with antibodies. Some antibodies require special sample preparation steps. For details, please refer to the “Remarks” section. Immunoprecipitation (IP); Immunoisolation or pulldown of a target molecule using an antibody. For details and product specific hints, please refer to the ”Remarks” section. Immunocytochemistry (ICC) on 4% PFA fixed cells. Immunoreactivity is usually revealed by fluorescence. Some antibodies require special fixation methods. For details, please refer to the “Remarks” section. Immunohistochemistry (IHC) on 4% PFA perfusion fixed tissue with 24h PFA post fixation. Immunoreactivity is usually revealed by fluorescence or a chromogenic substrate. Some antibodies require special fixation methods or antigen retrieval steps. For details, please refer to the ”Remarks” section. Immunohistochemistry (IHC-P) of formalin fixed, paraffin embedded (FFPE) tissue (some antibodies require special antigen retrieval steps, please refer to the ”Remarks” section). Immunoreactivity is usually revealed by fluorescence or a chromogenic substrate. Expansion Microscopy (ExM) is a sample preparation and imaging method which employs a dense interconnected web of swellable polymer within a biological specimen. A significantly higher effective resolution can be achieved with a standard microscope setup. For additional experimental details, please refer to the Remarks section.
Immunogen	Synthetic peptide corresponding to AA 89 to 100 from mouse Somatostatin (UniProt Id: P60041)
Reactivity	Reacts with: rat (P60042), mouse (P60041). Other species not tested yet.
Specificity	This antibody preferentially recognizes somatostatin-28. It only shows minor cross-reactivity to the unprocessed precursor protein and does not detect somatostatin-14.
Remarks	ExM: This antibody has been successfully used in LICONN expansion microscopy method (Tavakoli et al. 2025, PMID: 40335689).
Data sheet	366_006.pdf

References for Somatostatin-28 - 366 006

CXCL12 Engages Cortical Inhibitory Neurons to Enhance Dendritic Spine Plasticity and Structured Network Activity.
Ho C, Luchetta J, Nash B, Festa LK, Johnson JA, Sacan A, Jackson JG, Sanz-Clemente A, Brandimarti R, Meucci O
The Journal of neuroscience : the official journal of the Society for Neuroscience (2025) 4524: . 366 006 ICC; tested species: rat

Moderate beta-cell ablation triggers synergic compensatory mechanisms even in the absence of overt metabolic disruption.
Mathisen AF, Larsen U, Kavli N, Unger L, Daian LM, Vacaru AM, Vacaru AM, Herrera PL, Ghila L, Chera S
Communications biology (2024) 71: 833. 366 006 IHC; tested species: mouse

INSIHGT: an accessible multi-scale, multi-modal 3D spatial biology platform.
Yau CN, Hung JTS, Campbell RAA, Wong TCY, Huang B, Wong BTY, Chow NKN, Zhang L, Tsoi EPL, Tan Y, Li JJX, et al.
Nature communications (2024) 151: 10888. 366 006 IHC; tested species: mouse

Purkinje cell microzones mediate distinct kinematics of a single movement.
Blot FGC, White JJ, van Hattem A, Scotti L, Balaji V, Adolfs Y, Pasterkamp RJ, De Zeeuw CI, Schonewille M
Nature communications (2023) 141: 4358. 366 006 IHC; tested species: mouse

Amygdala inhibitory neurons as loci for translation in emotional memories.
Shrestha P, Shan Z, Mamcarz M, Ruiz KSA, Zerihoun AT, Juan CY, Herrero-Vidal PM, Pelletier J, Heintz N, Klann E
Nature (2020) 5867829: 407-411. 366 006 IHC; tested species: mouse

Light-microscopy-based connectomic reconstruction of mammalian brain tissue.
Tavakoli MR, Lyudchik J, Januszewski M, Vistunou V, Agudelo Dueñas N, Vorlaufer J, Sommer C, Kreuzinger C, Oliveira B, Cenameri A, Novarino G, et al.
Nature (2025) 6428067: 398-410. 366 006 ExM; tested species: mouse

Cat. No.: 366 006

Amount: 200 µl

Price: $385.00

ICC

IHC

IHC-P

Background

Somatostatin, also referred to as SST, growth hormone-inhibiting hormone or GHIH, is a peptide hormone that regulates the endocrine system and affects neurotransmission and cell proliferation via interaction with G protein-coupled somatostatin receptors. It inhibits the secretion of many important hormones, including insulin, glucagon and somatotropin (also designated growth hormone, or GH).
Somatostatin has two forms, active 14 amino acid and 28 amino acid. They are produced by alternative cleavage of the single precursor protein encoded by this gene.

For more information on protein expression pattern, please refer to the overview image in our SYSY Antibodies ATLAS.

1 ) Gahete MD et al., Ann. N. Y. Acad. Sci. (2010)
2 ) Brakch N et al., Biochemistry (2002)
3 ) Dournaud P et al., J. Neurosci. (1998)
4 ) Aguila MC et al., Endocrinology (1996)
5 ) Patel YC et al., Biochem. Biophys. Res. Commun. (1994)
6 ) Gomez S et al., EMBO J. (1989)
7 ) Shen LP et al., Science (1984)

Protocols

ICC

IHC

IHC-P

Other products for this target

Somatostatin-28 antibody - 366 006

References for Somatostatin-28 - 366 006