Cat. No.: 148-0P
Amount: 100 µg
Price:
$105.00
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| Cat. No. 148-0P |
100 µg protein, lyophilized. For reconstitution add 100 µl H2O to get a 1mg/ml solution in TBS. Then aliquot and store at -20°C to -80°C until use. Control proteins should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications |
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| Immunogen | Recombinant protein corresponding to AA 1 to 136 from rat Snapin (UniProt Id: P60192) |
| Recommended dilution | Optimal concentrations should be determined by the end-user. |
| Matching antibodies | 148 002 |
| Remarks |
This control peptide consists of the full-length rat snapin that has been used for immunization. It has been tested in preadsorption experiments and blocks efficiently and specifically the corresponding signal in Western blots. The amount of peptide needed for efficient blocking depends on the titer and on the affinity of the antibody to the antigen. |
| Data sheet | 148-0p.pdf |
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Snapin, also referred to as Snapap, was initially identified as a SNAP 25 interacting protein which enhances the binding of synaptotagmin 1 to SNAREs in a phosphorylation dependent manner. Later an ubiquitous expression pattern in neuronal and non-neuronal cells and interaction with SNAP 23 was described. The protein contains heptad repeats typical for coiled coils in its C-terminal part.
The role of this protein in SNARE mediated fusion is still under discussion.