Cat. No.: 111 113
Amount: 50 µg
Price:
$375.00
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| Cat. No. 111 113 |
50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin was added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications | |
| Immunogen | Synthetic peptide corresponding to AA 58 to 72 from rat SNAP25B (UniProt Id: P60881-1) |
| Reactivity |
Reacts with: rat (P60881-1), mouse (P60879-1). Other species not tested yet. |
| Specificity | Specific for SNAP 25B, no cross-reactivity to SNAP 25A. K.O. validated PubMed: 31024034 |
| Data sheet | 111_113.pdf |
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SNAP 25 (synaptosome-associated protein of 25 kDa) is a highly conserved protein anchored to the cytosolic face of membranes via palmitoyl side chains in the middle of the molecule. SNAP 25 is the target of Botulinum neurotoxin A and E which cleave off 9 and 26 amino acids, respectively, from the C-terminus.
SNAP 25 is part of the exocytotic fusion complex (v-SNARE) of neurons where it assembles with syntaxin 1 and synaptobrevin. It is abundantly localized on the neuronal plasmalemma and on recycling vesicles including synaptic vesicles. It is also expressed in neuroendocrine cells. There are two splice-variants, SNAP 25A and 25B.