Cat. No.: 111 004
Amount: 100 µl
Price:
$365.00
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| Cat. No. 111 004 |
100 µl antiserum, lyophilized. For reconstitution add 100 µl H2O, then aliquot and store at -20°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications |
IP: yes ICC: not tested yet IHC: not tested yet IHC-P: not tested yet |
| Immunogen | Synthetic peptide corresponding to AA 192 to 206 from human SNAP25 (UniProt Id: P60880) |
| Reactivity |
Reacts with: human (P60880), rat (P60881), mouse (P60879), hamster, chicken, goldfish, zebrafish. Other species not tested yet. |
| Matching control protein/peptide | 111-0P |
| Data sheet | 111_004.pdf |
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SNAP 25 (synaptosome-associated protein of 25 kDa) is a highly conserved protein anchored to the cytosolic face of membranes via palmitoyl side chains in the middle of the molecule. SNAP 25 is the target of Botulinum neurotoxin A and E which cleave off 9 and 26 amino acids, respectively, from the C-terminus.
SNAP 25 is part of the exocytotic fusion complex (v-SNARE) of neurons where it assembles with syntaxin 1 and synaptobrevin. It is abundantly localized on the neuronal plasmalemma and on recycling vesicles including synaptic vesicles. It is also expressed in neuroendocrine cells. There are two splice-variants, SNAP 25A and 25B.