Cat. No.: 111 203
Amount: 50 µg
Price:
$455.00
Cat. No. 111 203 |
50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
Applications |
Immunoprecipitation (IP); Immunoisolation or pulldown of a target molecule using an antibody. For details and product specific hints, please refer to the ”Remarks” section.', $event)" style="cursor: help;">IP: yes (see remarks) Immunocytochemistry (ICC) on 4% PFA fixed cells. Immunoreactivity is usually revealed by fluorescence. Some antibodies require special fixation methods. For details, please refer to the “Remarks” section.', $event)" style="cursor: help;">ICC: 1 : 500 Immunohistochemistry (IHC) on 4% PFA perfusion fixed tissue with 24h PFA post fixation. Immunoreactivity is usually revealed by fluorescence or a chromogenic substrate. Some antibodies require special fixation methods or antigen retrieval steps. For details, please refer to the ”Remarks” section.', $event)" style="cursor: help;">IHC: yes Immunohistochemistry (IHC-P) of formalin fixed, paraffin embedded (FFPE) tissue (some antibodies require special antigen retrieval steps, please refer to the ”Remarks” section). Immunoreactivity is usually revealed by fluorescence or a chromogenic substrate.', $event)" style="cursor: help;">IHC-P: not tested yet |
Immunogen | Synthetic peptide corresponding to AA 196 to 211 from human SNAP23 (UniProt Id: O00161) |
Reactivity |
Reacts with: human (O00161), rat (O70377), mouse (O09044), hamster, pig, rabbit. Other species not tested yet. |
Specificity | K.O. validated PubMed: 32051343 |
Matching control protein/peptide | 111-2P |
Remarks |
IP: Cat. no. 111 213 is recommended |
Data sheet | 111_203.pdf |
SNAP 23 (synaptosome-associated protein of 23 kDa) is an ubiquitously expressed isoform and functional homologue of SNAP 25. It is resistant to cleavage by BoNT/A and E. The protein is part of the exocytotic fusion complex (v-SNARE) where it assembles with syntaxin 1 and synaptobrevin.
SNAP 23 is able to function in regulated exocytosis. Both isoforms may have their own specific binding partners and discrete, albeit mechanistically similar, functional roles within the cell.