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SY SY - Synaptic Systems SY SY - Synaptic Systems

Sec 22b - 186 003

A SNARE protein involved in ER to Golgi transport

Polyclonal rabbit purified antibody
370.00 USD
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Cat. No. 186 003 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin was added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C until use.
Applications WB: 1 : 1000 up to 1 : 5000 (AP staining) gallery  
IP: yes
ICC: 1 : 100 up to 1 : 500 gallery  
IHC: 1 : 100 gallery  
IHC-P/FFPE: 1 : 200 gallery  
Immunogen Recombinant protein corresponding to AA 1 to 176 from rat Sec22b (UniProt Id: Q4KM74)
Reactivity Reacts with: human (O75396), rat (Q4KM74), mouse (O08547), zebrafish.
Other species not tested yet.
Specificity Specific for sec 22b. (K.D. verified)
Datasheet 186_003.pdf


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References for Sec 22b - 186 003

Autophagy induction via STING trafficking is a primordial function of the cGAS pathway.
Gui X, Yang H, Li T, Tan X, Shi P, Li M, Du F, Chen ZJ
Nature (2019) : . 186 003 WB; tested species: human
Identification of a Botulinum Neurotoxin-like Toxin in a Commensal Strain of Enterococcus faecium.
Zhang S, Lebreton F, Mansfield MJ, Miyashita SI, Zhang J, Schwartzman JA, Tao L, Masuyer G, Martínez-Carranza M, Stenmark P, Gilmore MS, et al.
Cell host & microbe (2018) 232: 169-176.e6. 186 003 WB; tested species: mouse
MHC I presentation of Toxoplasma gondii immunodominant antigen does not require Sec22b and is regulated by antigen orientation at the vacuole membrane.
Buaillon C, Guerrero NA, Cebrian I, Blanié S, Lopez J, Bassot E, Vasseur V, Santi-Rocca J, Blanchard N
European journal of immunology (2017) 477: 1160-1170. 186 003 WB; KD verified; tested species: mouse
Identification and characterization of a novel botulinum neurotoxin.
Zhang S, Masuyer G, Zhang J, Shen Y, Lundin D, Henriksson L, Miyashita SI, Martínez-Carranza M, Dong M, Stenmark P
Nature communications (2017) 8: 14130. 186 003 WB; tested species: mouse
Highly potent intracellular membrane-associated Aβ seeds.
Marzesco AM, Flötenmeyer M, Bühler A, Obermüller U, Staufenbiel M, Jucker M, Baumann F
Scientific reports (2016) 6: 28125. 186 003 WB
Sec22b regulates phagosomal maturation and antigen crosspresentation by dendritic cells.
Cebrian I, Visentin G, Blanchard N, Jouve M, Bobard A, Moita C, Enninga J, Moita LF, Amigorena S, Savina A
Cell (2011) 1476: 1355-68. 186 003 WB, ICC; tested species: mouse
Molecular anatomy of a trafficking organelle.
Takamori S, Holt M, Stenius K, Lemke EA, Grønborg M, Riedel D, Urlaub H, Schenck S, Brügger B, Ringler P, Müller SA, et al.
Cell (2006) 1274: 831-46. 186 003 WB; tested species: rat
Sec22b regulates phagosomal maturation and antigen crosspresentation by dendritic cells.
Cebrian I, Visentin G, Blanchard N, Jouve M, Bobard A, Moita C, Enninga J, Moita LF, Amigorena S, Savina A
Cell (2011) 1476: 1355-68. 186 003 WB, ICC; tested species: mouse
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Synaptic Systems GmbH | Rudolf-Wissell-Str. 28 | 37079 Göttingen | Germany
Phone: +49 (0)551/505 56-0 | Internet: http://www.sysy.com | E-Mail: sales@sysy.com