Synaptic Systems - Synaptotagmin4

Cat. No.: 105 043

Amount: 50 µg

Price: $380.00

Cat. No. 105 043	50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin was added for stabilization. For reconstitution add 50 µl H₂O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications	WB: 1 : 100 up to 1 : 1000 (AP staining) gallery IP: yes ICC: not recommended (see remarks) IHC: not recommended IHC-P: not tested yet
Immunogen	Recombinant protein corresponding to AA 40 to 151 from rat Synaptotagmin4 (UniProt Id: P50232)
Reactivity	Reacts with: rat (P50232), mouse (P40749). Other species not tested yet.
Specificity	K.O. validated
Matching control protein/peptide	105-4P
Remarks	ICC: Cat. no. 105 143 is recommended.
Data sheet	105_043.pdf

Deficiency of PKA-mediated SNAP-25b phosphorylation destabilizes exocytotic fusion pores and reduces the interactions of t-SNAREs.
Hsiao YT, Su YL, Chen PC, Huang CT, Hsieh YY, Chiang N, Lin YC, Lu JC, Wang CT
The Journal of physiology (2025) : . 105 043 WB; tested species: rat

REST/NRSF drives homeostatic plasticity of inhibitory synapses in a target-dependent fashion.
Prestigio C, Ferrante D, Marte A, Romei A, Lignani G, Onofri F, Valente P, Benfenati F, Baldelli P
eLife (2021) 10: . 105 043 WB; tested species: mouse

Synaptotagmin 4 Regulates Pancreatic β Cell Maturation by Modulating the Ca2+ Sensitivity of Insulin Secretion Vesicles.
Huang C, Walker EM, Dadi PK, Hu R, Xu Y, Zhang W, Sanavia T, Mun J, Liu J, Nair GG, Tan HYA, et al.
Developmental cell (2018) 453: 347-361.e5. 105 043 WB, IHC; tested species: mouse

Synaptotagmin oligomerization is essential for calcium control of regulated exocytosis.
Bello OD, Jouannot O, Chaudhuri A, Stroeva E, Coleman J, Volynski KE, Rothman JE, Krishnakumar SS
Proceedings of the National Academy of Sciences of the United States of America (2018) 11532: E7624-E7631. 105 043 WB; tested species: rat

Reduced insulin secretion correlates with decreased expression of exocytotic genes in pancreatic islets from patients with type 2 diabetes.
Andersson SA, Olsson AH, Esguerra JL, Heimann E, Ladenvall C, Edlund A, Salehi A, Taneera J, Degerman E, Groop L, Ling C, et al.
Molecular and cellular endocrinology (2012) 3641-2: 36-45. 105 043 WB

Cell therapy modulates expression of Tax1-binding protein 1 and synaptotagmin IV in a model of optic nerve lesion.
Mesentier-Louro LA, Coronel J, Zaverucha-do-Valle C, Mencalha A, Paredes BD, Abdelhay E, Mendez-Otero R, Santiago MF
Investigative ophthalmology & visual science (2012) 538: 4720-9. 105 043 WB, IHC

Distinct subsets of Syt-IV/BDNF vesicles are sorted to axons versus dendrites and recruited to synapses by activity.
Dean C, Liu H, Staudt T, Stahlberg MA, Vingill S, Bückers J, Kamin D, Engelhardt J, Jackson MB, Hell SW, Chapman ER, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2012) 3216: 5398-413. 105 043 WB, ICC

REST/NRSF governs the expression of dense-core vesicle gliosecretion in astrocytes.
Prada I, Marchaland J, Podini P, Magrassi L, D'Alessandro R, Bezzi P, Meldolesi J
The Journal of cell biology (2011) 1933: 537-49. 105 043 WB

Deferoxamine-induced neurite outgrowth and synapse formation in postnatal rat dorsal root ganglion (DRG) cell cultures.
Nowicki M, Kosacka J, Spanel-Borowski K, Borlak J
European journal of cell biology (2009) 8810: 551-62. 105 043 WB

Synaptotagmin-IV modulates synaptic function and long-term potentiation by regulating BDNF release.
Dean C, Liu H, Dunning FM, Chang PY, Jackson MB, Chapman ER
Nature neuroscience (2009) 126: 767-76. 105 043 WB, app.icc; ip

Synaptotagmin IV: a multifunctional regulator of peptidergic nerve terminals.
Zhang Z, Bhalla A, Dean C, Chapman ER, Jackson MB
Nature neuroscience (2009) 122: 163-71. 105 043 WB, EM

Cat. No.: 105 043

Amount: 50 µg

Price: $380.00

Background

Protocols

Synaptotagmin4 antibody - 105 043 K.O.