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Home > Products > 105 225

Synaptotagmin2 antibody luminal domain - 105 225

Synaptotagmin2 is an alternative Ca2+-sensor for neurotransmitter release
Guinea pig polyclonal purified antibody
Cat. No.: 105 225
Amount: 50 µg
Price: $460.00
Cat. No. 105 225 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin was added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 1000 AP staining gallery  
IP: yes
ICC: 1 : 500 up to 1 : 1000 gallery  
IHC: 1 : 500 gallery  
IHC-P: not tested yet
Immunogen Synthetic peptide corresponding to AA 1 to 11 from mouse Synaptotagmin2 (UniProt Id: P46097)
Reactivity Reacts with: mouse (P46097), rat (P29101).
Other species not tested yet.
Data sheet 105_225.pdf

References for Synaptotagmin2 - 105 225

Simulations of active zone structure and function at mammalian NMJs predict that loss of calcium channels alone is not sufficient to replicate LEMS effects.
Ginebaugh SP, Badawi Y, Laghaei R, Mersky G, Wallace CJ, Tarr TB, Kaufhold C, Reddel S, Meriney SD
Journal of neurophysiology (2023) : . 105 225 IHC; tested species: mouse
Cat. No.: 105 225
Amount: 50 µg
Price: $460.00
Simulations of active zone structure and function at mammalian NMJs predict that loss of calcium channels alone is not sufficient to replicate LEMS effects.
Ginebaugh SP, Badawi Y, Laghaei R, Mersky G, Wallace CJ, Tarr TB, Kaufhold C, Reddel S, Meriney SD
Journal of neurophysiology (2023) : . 105 225 IHC; tested species: mouse
WB
ICC
IHC
IHC
IHC
Background

Synaptotagmin 2 is an integral membrane glycoprotein of neuronal synaptic vesicles. It is very similar to synaptotagmin 1 but shows a partly complementary expression pattern in the CNS. Synaptotagmin 2 lacks a CAMK II/PKC phosphorylation site which is present in synaptotagmin 1.
Recently synaptotagmin 2 has been shown to be an alternative Ca2+ sensor for fast secretion.
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